The abundance,distribution,and enrichment mechanism of harmful trace elements in coals from Guizhou,Southwestern China

Coal seams can enrich a variety of harmful trace elements under specific geological conditions.The spatial distribution of harmful trace elements in coal is extremely uneven,and the distribution characteristics of each element content are different.The harmful elements released in the process of coal mining and utilization will cause serious harm to the environment and the human body.It is of great resource significance to study the geochemistry of coal that affects the enrichment and distribution characteristics of harmful trace elements.Based on the domestic and foreign literature on coal geochemistry in Guizhou published by previous investigators,this study counted 1097 sample data from 23 major coal-producing counties in Guizhou Province,systematically summarized the relevant research results of harmful trace elements in the coal of Guizhou,and revealed the overall distribution and enrichment characteristics of harmful trace elements in the coal of Guizhou.The results show that the average contents of Cd,Pb,Se,Cu,Mo,U,V,As,Hg,and Cr in coal of Guizhou are higher than those in Chinese coal and world coal.A variety of harmful trace elements in the coal of Guizhou have high background values,especially in Liupanshui,Xingyi and Qianbei coalfield.The enrichment of various harmful trace elements in the Late Permian coal in Guizhou is mainly related to the combined action of various geological and geochemical factors.The supply of terrigenous debris and sedimentary environment may be the basic background of the enrichment of harmful elements in western Guizhou,while low-temperature hydrothermal activity and volcanic ash deposition may be the main reasons for the enrichment of harmful elements in southwestern Guizhou.

Metabolomic Analysis of the Anthocyanins Associated with Different Colors of Cymbidium goeringii in Guizhou, China

Cymbidium goeringii is an economically important ornamental plant,and flower color is one of the main features of C.goeringii that contributes to its high economic value.To clarify the molecular mechanisms underlying the role of anthocyanins in mediating differences in color among varieties,liquid chromatography–tandem mass spectrometry was used to perform anthocyanin-targeted metabolomics of seven C.goeringii varieties,including‘Jin Qian Yuan’(JQY),‘Jin Xiu Qian Yuan’(JXQY),‘Miao Jiang Su Die’(MJSD),‘Qian Ming Su’(QMS),‘Shi Chan’(SC),and‘Yang Ming Su’(YMS),as well as the C.goeringii.We detected 64 anthocyanins,including cyanidins,delphinidins,malvidins,pelargonidins,peonidins,petunidins,procyanidins,and flavonoids.We identified six shared differentially accumulated metabolites(DAMs),including cyanidin-3-O-rutinoside,delphinidin-3-Osophoroside,pelargonidin-3-O-rutinoside,peonidin-3-O-(6-O-malonyl-beta-D-glucoside),peonidin-3-Osophoroside,and chalcone.Most DAMs were enriched in the anthocyanin biosynthesis pathway.Kyoto Encyclopedia of Genes and Genomes pathway analysis revealed that the differentially expressed metabolites were significantly enriched in the anthocyanin biosynthesis pathway.Analysis of the content of differentially expressed metabolites indicated that peonidin-3-O-(6-O-malonyl-beta-D-glucoside)was the key metabolite underlying color differences among C.goeringii varieties.Procyanidin B2,pelargonidin-3-O-galactoside,and naringenin might also affect the color formation of JQY and QMS,SC,and MJSD,respectively.The results of this study shed light on the metabolic mechanism underlying flower color differences in C.goeringii at the molecular level.Our findings will aid future studies of the mechanism of flower color regulation in C.goeringii and have implications for the breeding of new varieties.

Mineralogical study and significance of the basalt-hosted Carlin-type Au deposits in southwestern Guizhou Province,China

The Jiadi and Damaidi gold deposits in southwest Guizhou Province are the largest basalt-hosted Carlintype gold deposits recently discovered in China.This study uses the Tescan Integrated Mineral Analyzer,supported by detailed field investigations,regional geological data,and extensive sample collections,including mineralized ore,altered wall rock,and unaltered basalt samples,for orebearing and geochemical analyses.Comparative analysis between altered and unaltered basalt samples revealed a mineral assemblage of sericite,quartz,and pyrite.This mineral composition forms through the hydrothermal alteration of unaltered basalt,originally containing feldspar,pyroxene,and ilmenite.The wall rock primarily features sericite,quartz,and hematite.During the alteration process,major,trace,and rare earth elements notably migrate.In the Jiadi deposit,K_(2)O,Rb,Au,and REE significantly increase,while Na_(2)O,CaO,MgO,and MnO decrease.SiO_(2),Al_(2)O_(3),and Fe_(2)O_(3)levels remain relatively stable.In the Damaidi deposit,K_(2)O,Rb,and Au enrich,contrasting with the depletion of Na_(2)O,CaO,MgO,and MnO,while SiO_(2),Fe_(2)O_(3),Al_(2)O_(3),TiO_(2),and REE show no significant changes.In the wall rock,TiO_(2),Al_(2)O_(3),K_(2)O,and REE increase,while Na_(2)O,CaO,MgO,and MnO decrease;SiO_(2)and Fe_(2)O_(3)content remains unchanged.The mineralization process likely originated from mid-to low-temperature,reductive magmatic hydrothermal fluids rich in CO_(2),CH_(4),N_(2),H^(+),S^(2-),HS^(-),H_(3)AsO_(3),and[Au(HS_(2)]^(-).These fluids migrated to tectonically weak zones in the Lianhuashan area,where Emeishan basalts are present.They reacted with Fe-bearing minerals in the basalt,such as ferro-hornblende and ilmenite,forming pyrite,arsenic-bearing pyrite,and arsenopyrite,thus enriching Au in these minerals.Additionally,K^(+)and H^(+)in the fluid reacted with plagioclase in the basalt,forming sericite and quartz.As the fluid entered the wall rock from structural weak zones,its oxidation increased,leading to the complete or partial reaction of Fe-bearing minerals in the wall rock,resulting in the formation of hematite or magnetite.This mineralization process is similar to that observed in carbonate-hosted Carlin-type gold deposits in southwest Guizhou,with the primary distinction being the iron source.In carbonate deposits,iron originates from ferridolomite within the wall rock,while in basalt-hosted deposits,it derives from ferripyroxene and ilmenite.

Chinese New Year Folk Culture Adds Impetus to Guizhou's Colorful Tourism Economy

During the Chinese New Year in 2024,a series of traditional folk activities were held all over Guizhou,attracting a large number of travelers,with the number of received travelers and comprehensive income of Guizhou reaching a new high.

The Process of Tiger Disappearance in Guizhou

In this paper,the authors collected officially published literature on the South China tiger(Panthera tigris amoyensis)in Guizhou from 1900 to 1980,from which we extracted information on its historical distribution and population size,and collected data on the tiger skin trade after 1950,the change in subtropical broad-leaved evergreen forest cover,and demographic data in the relevant databases.GIS mapping was used to visualize the distribution range of the South China tiger in Guizhou Province during the period 1900–1980 and to discuss the history of its disappearance in Guizhou and its driving factors.The results show that in 1900,the South China tiger was distributed throughout 82 cities and counties in nine prefectures and municipalities in the province;the number of documented South China tiger distribution sites in 1900–1950 decreased to 48 compared to 1900;the number of counties with South China tigers in 1950–1980 further decreased and became extinct in some areas;and in the 1990s,the South China tiger became extinct in the wild in Guizhou.The main reasons for the extinction of the South China tiger in the wild in Guizhou are:on the one hand,with the socio-economic development of Guizhou Province,the population has increased dramatically,the magnitude of the demand for natural resources has increased,and in order to satisfy this demand,human activities,such as coal mining and clearing of mountains for planting,have been intensified,resulting in the reduction of the coverage rate of the subtropical broad-leaved evergreen forests,which has resulted in the extreme loss of the habitat of the South China tiger;on the other hand,the insufficient protection efforts and protection measures for this species in the country before the 1980s,which were subjected to anthropogenic hunting,were also factors leading to the extinction of this species in the wild in Guizhou Province.As a big cat at the top of the food chain,the distribution of the South China tiger can reflect the history of the natural environment in the region.By analyzing and discussing the distribution history of the South China tiger population in Guizhou Province,the significance of this case is to provide a scientific basis for the future conservation of biodiversity and the development of ecological restoration measures in the karst mountains of southern China.

Genesis, metallogenic model, and prospecting prediction of the Nibao gold deposit in the Guizhou Province, China

Southwestern Guizhou province is one of China’s most important distribution areas of Carlin-type gold deposits. The Nibao deposit is a typical gold deposit in southwestern Guizhou. To elucidate the genesis of the Nibao gold deposit, establish a metallogenic model, and guide prospecting prediction, we systematically collected previously reported geological, geochemical, and dating data and discussed the genesis of the Nibao gold deposit,based on which we proposed the metallogenic model.Earlier works show that the Nibao anticline, F1 fault, and its hanging wall dragged anticline(Erlongqiangbao anticline) were formed before or simultaneously with gold mineralization, while F2, F3, and F4 faults postdate gold mineralization. Regional geophysical data showed extensive low resistivity anomaly areas near the SBT(the product of tectonic slippage and hydrothermal alteration)between the P2/P3 and the strata of the Longtan Formation in the SSE direction of Nibao anticline in the lower plate of F1 and hanging wall dragged anticline(Erlongqiangbao anticline), and the anomaly areas are distributed within the influence range of anticlines. Simultaneously, soil and structural geochemistry show that F1, Nibao anticline,Erlongqiangbao anticline, and their transition areas all show good metallogenic elements(Au, As, and S) assemblage anomalies, with good metallogenic space and prospecting possibilities. There are five main hypotheses about the source of ore-forming fluids and Au in the Nibao gold deposit:(1) related to the Emeishan mantle plume activity;(2) source from the Emeishan basalt;(3) metamorphic fluid mineralization;(4) basin fluid mineralization;(5) related to deep concealed magmatic rocks;of these, the mainstream understanding is the fifth speculation. It is acknowledged that the ore-forming fluids are hydrothermal fluids with medium–low temperature, high pressure, medium–low salinity, low density, low oxygen fugacity, weak acidity, weak reduction, and rich in CO_(2)and CH_(4). The fluid pressure is 2–96.54 MPa, corresponding to depths of 0.23–3.64 km. The dating results show that the metallogenic age is ~141 Ma, the extensional tectonic environment related to the westward subduction of the Pacific Plate. Based on the above explanation, the genetic model related to deep concealed magmatic rocks of the Nibao gold deposit is established, and favorable prospecting areas are outlined;this is of great significance for regional mineral exploration and studying the genesis of gold deposits.

Population dynamics and protection strategies of Litsea coreana Levl.var.sinensis with Guizhou Province in China as an example

Studying the dynamics of plant populations is crucial to the conservation and management of endangered plants.The diameter at breast height(DBH),tree height,crown width,and environmental factors of a total of 15 plots in five populations in Guizhou Province,China were measured in this study.The method of substituting diameter at breast height for age was used to divide the population into 7 age classes.The age structure,static life table,and relationship between the population characteristics and environmental factors of the Litsea coreana Levl.var.sinensis population were studied.Moreover,the time series model was used to predict the population dynamics.Results showed that the age structure of population in Zhengan County(Population ZA)had an inverted Jshape with abundant seedlings and insufficient middle-aged and elderly individuals.The age structures of populations in Daozhen County(Population DZ),Kaiyang County(KY),Meitan County(Population MT),and Xishui County(Population XS)were spindle-shaped with few young individuals and many middle-aged and elderly individuals.The mortality rate of each population fluctuated with the increase in age class,and the populations were extremely unstable.The survival curve was close to the Deevey III type,and the degree of deviation was related to the lack of young individuals.After the age stages II,IV,and VI,the number of aged plants in the different populations initially increased then decreased,and population stability was difficult to maintain.Redundancy analysis showed that the DBH,tree height and crown width of the population decreased with the increase of annual mean temperature,and the population density was restricted by soil nutrient conditions to a certain extent.The results of this work provide scientific basis for the conservation and sustainable utilization of natural populations of L.coreana var.sinensis in Guizhou Province,China.

Influence of Guizhou Dialect on Pronunciation of English Majors in Guizhou Medical University

Different regions have different dialects. It causes affections on students' English phonetics. Many dialects in Guizhou, having unique pronunciation from mandarin, are hard to understand even to local people, which become the major obstacle for many English learners in our province. This paper takes English majors in Guizhou Medical University for example, analyzing their common problems in pronunciation, such as [l]. [r]; [l]. [n]; [θ]. [e]; [f] and [v], and then discussing the causes. Finally, this paper finds out some solutions to the problem. It is hoped that this paper could provide some food of thought for new English teachers.

Lake regime shift from submerged macrophyte to phytoplankton affected phosphorus speciation in sediment and eutrophic state in Caohai Lake,Guizhou,China

To understand the effect of regime shift in Caohai Lake in Yunnan-Guizhou Plateau,SW China from submerged macrophyte dominance to phytoplankton dominance on the specification and distribution of phosphorus and on ecological and environmental states,changes in phosphorus specification in the sediments and water were studied.The form,composition,and distribution of phosphorus in sediment were sampled in July 2020(before regime shift)and July 2021(after regime shift)were analyzed.Results reveal that phosphorus content in sediment was lower than that those of Erhai Lake and Dianchi Lake,Yunnan,SW China,on the same plateau,and was lower than those of Taihu Lake,Chaohu Lake,and Poyang Lake in the middle-lower Changjiang(Yangtze)River Plain.Organic phosphorus(Or-P)was the main form(up to 60%),followed by inactive phosphorus(Ina-P),and the active phosphorus(Act-P),the least,which is opposite to those of Taihu Lake and Poyang Lake in the middle-lower Changjiang River Plain in the eastern China.Or-P content was high,indicating a high potential risk of phosphorous release.After the regime shift,the total phosphorus in sediment decreased from 0.87±0.13 to 0.70±0.13 g/kg.The proportion of Or-P and Act-P decreased from 68.23% to 65.32% and from 5.35% to 4.69%,respectively.In contrast,the proportion of Ina-P increased from 26.42% to 29.99%.The Moran’s I index revealed that the heterogeneity of the spatial distributions of the total phosphorus(S-TP)and Act-P in the sediments before regime shift was significant(P<0.1).However,the heterogeneity of the spatial distributions of S-TP and the various forms of phosphorus after regime shift was not significant(P>0.05).The regime shift aggravated the eutrophication of the lake,the trophic level index(TLI)increased from 48.42 to 54.49(P<0.01),and the previously mesotrophic lake became a mildly eutrophic lake.The results of this study revealed the impact of regime shift in the lake from submerged macrophyte dominance to phytoplankton dominance on the composition and spatial distribution of phosphorus in sediments and provided a basis for the restoration of eutrophicated and aquatic ecosystem degraded lakes.

Silent information regulator sirtuin 1 ameliorates acute liver failure via the p53/glutathione peroxidase 4/gasdermin D axis

BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.

Industrial Carbon Emission Distribution and Regional Joint Emission Reduction:A Case Study of Cities in the Pearl River Basin,China

China’s low-carbon development path will make significant contributions to achieving global sustainable development goals.Due to the diverse natural and economic conditions across different regions in China,there exists an imbalance in the distribution of car-bon emissions.Therefore,regional cooperation serves as an effective means to attain low-carbon development.This study examined the pattern of carbon emissions and proposed a potential joint emission reduction strategy by utilizing the industrial carbon emission intens-ity(ICEI)as a crucial factor.We utilized social network analysis and Local Indicators of Spatial Association(LISA)space-time trans-ition matrix to investigate the spatiotemporal connections and discrepancies of ICEI in the cities of the Pearl River Basin(PRB),China from 2010 to 2020.The primary drivers of the ICEI were determined through geographical detectors and multi-scale geographically weighted regression.The results were as follows:1)the overall ICEI in the Pearl River Basin is showing a downward trend,and there is a significant spatial imbalance.2)There are numerous network connections between cities regarding the ICEI,but the network structure is relatively fragile and unstable.3)Economically developed cities such as Guangzhou,Foshan,and Dongguan are in the center of the network while playing an intermediary role.4)Energy consumption,industrialization,per capita GDP,urbanization,science and techno-logy,and productivity are found to be the most influential variables in the spatial differentiation of ICEI,and their combination in-creased the explanatory power of the geographic variation of ICEI.Finally,through the analysis of differences and connections in urban carbon emissions under different economic levels and ICEI,the study suggests joint carbon reduction strategies,which are centered on carbon transfer,financial support,and technological assistance among cities.

Effects of thinning on the understory light environment of different stands and the photosynthetic performance and growth of the reforestation species Phoebe bournei

Light levels determine regeneration in stands and a key concern is how to regulate the light environment of different stand types to the requirements of the understory.In this study,we selected three stands typical in south China(a Cryptomeria japonica plantation,a Quercus acutissima plantation,and a mixed stand of both)and three thinning intensities to determine the best understory light environ-ment for 3-year-old Phoebe bournei seedlings.The canopy structure,understory light environment,and photosynthe-sis and growth indicators were assessed following thin-ning.Thinning improved canopy structure and understory light availability of each stand;species composition was the reason for differences in the understory light environ-ment.Under the same thinning intensity,the mixed stand had the greatest light radiation and most balanced spectral composition.P.bournei photosynthesis and growth were closely related to the light environment;all three stands required heavy thinning to create an effective and sustained understory light environment.In a suitable understory light environment,the efficiency of light interception,absorption,and use by seedlings was enhanced,resulting in a higher carbon assimilation the main limiting factor was stomatal conductance.As a shade-avoidance signal,red/far-red radia-tion is a critical factor driving changes in photosynthesis and growth of P.bournei seedlings,and a reduction increased light absorption and use capacity and height:diameter ratios.The growth advantage transformed from diameter to height,enabling seedlings to access more light.Our findings suggest that the regeneration of shade-tolerant species such as P.bournei could be enhanced if a targeted approach to thinning based on stand type was adopted.

Mixed‑Dimensional Assembly Strategy to Construct Reduced Graphene Oxide/Carbon Foams Heterostructures for Microwave Absorption,Anti‑Corrosion and Thermal Insulation

Considering the serious electromagnetic wave(EMW)pollution problems and complex application condition,there is a pressing need to amalgamate multiple functionalities within a single substance.However,the effective integration of diverse functions into designed EMW absorption materials still faces the huge challenges.Herein,reduced graphene oxide/carbon foams(RGO/CFs)with two-dimensional/three-dimensional(2D/3D)van der Waals(vdWs)heterostructures were meticulously engineered and synthesized utilizing an efficient methodology involving freeze-drying,immersing absorption,secondary freeze-drying,followed by carbonization treatment.Thanks to their excellent linkage effect of amplified dielectric loss and optimized impedance matching,the designed 2D/3D RGO/CFs vdWs heterostructures demonstrated commendable EMW absorption performances,achieving a broad absorption bandwidth of 6.2 GHz and a reflection loss of-50.58 dB with the low matching thicknesses.Furthermore,the obtained 2D/3D RGO/CFs vdWs heterostructures also displayed the significant radar stealth properties,good corrosion resistance performances as well as outstanding thermal insulation capabilities,displaying the great potential in complex and variable environments.Accordingly,this work not only demonstrated a straightforward method for fabricating 2D/3D vdWs heterostructures,but also outlined a powerful mixeddimensional assembly strategy for engineering multifunctional foams for electromagnetic protection,aerospace and other complex conditions.

Federated Learning Model for Auto Insurance Rate Setting Based on Tweedie Distribution

In the assessment of car insurance claims,the claim rate for car insurance presents a highly skewed probability distribution,which is typically modeled using Tweedie distribution.The traditional approach to obtaining the Tweedie regression model involves training on a centralized dataset,when the data is provided by multiple parties,training a privacy-preserving Tweedie regression model without exchanging raw data becomes a challenge.To address this issue,this study introduces a novel vertical federated learning-based Tweedie regression algorithm for multi-party auto insurance rate setting in data silos.The algorithm can keep sensitive data locally and uses privacy-preserving techniques to achieve intersection operations between the two parties holding the data.After determining which entities are shared,the participants train the model locally using the shared entity data to obtain the local generalized linear model intermediate parameters.The homomorphic encryption algorithms are introduced to interact with and update the model intermediate parameters to collaboratively complete the joint training of the car insurance rate-setting model.Performance tests on two publicly available datasets show that the proposed federated Tweedie regression algorithm can effectively generate Tweedie regression models that leverage the value of data fromboth partieswithout exchanging data.The assessment results of the scheme approach those of the Tweedie regressionmodel learned fromcentralized data,and outperformthe Tweedie regressionmodel learned independently by a single party.

Correlative factors of poor prognosis and abnormal cellular immune function in patients with Alzheimer’s disease

BACKGROUND Alzheimer’s disease(AD)is a serious disease causing human dementia and social problems.The quality of life and prognosis of AD patients have attracted much attention.The role of chronic immune inflammation in the pathogenesis of AD is becoming more and more important.AIM To study the relationship among cognitive dysfunction,abnormal cellular immune function,neuroimaging results and poor prognostic factors in patients.METHODS A retrospective analysis of 62 hospitalized patients clinical diagnosed with AD who were admitted to our hospital from November 2015 to November 2020.Collect cognitive dysfunction performance characteristics,laboratory test data and neuroimaging data from medical records within 24 h of admission,including Mini Mental State Examination Scale score,drawing clock test,blood T lymphocyte subsets,and neutrophils and lymphocyte ratio(NLR),disturbance of consciousness,extrapyramidal symptoms,electroencephalogram(EEG)and head nucleus magnetic spectroscopy(MRS)and other data.Multivariate logistic regression analysis was used to determine independent prog-nostic factors.the modified Rankin scale(mRS)was used to determine whether the prognosis was good.The correlation between drug treatment and prognostic mRS score was tested by the rank sum test.RESULTS Univariate analysis showed that abnormal cellular immune function,extrapyramidal symptoms,obvious disturbance of consciousness,abnormal EEG,increased NLR,abnormal MRS,and complicated pneumonia were related to the poor prognosis of AD patients.Multivariate logistic regression analysis showed that the decrease in the proportion of T lym-phocytes in the blood after abnormal cellular immune function(odd ratio:2.078,95%confidence interval:1.156-3.986,P<0.05)was an independent risk factor for predicting the poor prognosis of AD.The number of days of donepezil treatment to improve cognitive function was negatively correlated with mRS score(r=0.578,P<0.05).CONCLUSION The decrease in the proportion of T lymphocytes may have predictive value for the poor prognosis of AD.It is recommended that the proportion of T lymphocytes<55%is used as the cut-off threshold for predicting the poor prog-nosis of AD.The early and continuous drug treatment is associated with a good prognosis.

Appendiceal intussusception complicated by adenocarcinoma of the cecum:A case report

BACKGROUND Appendiceal intussusception is a pathological condition in which the appendix is inverted into the cecum,which may cause symptoms that resemble those of other gastrointestinal disorders and may induce intestinal obstruction.The rarity of this case presentation is the co-occurrence of appendiceal intussusception and cecal adenocarcinoma,a combination that to our knowledge has not previously been reported in the medical literature.This case provides new insights into the complexities of diagnosing and managing overlapping pathologies.CASE SUMMARY A 25-year-old woman presented with persistent periumbilical pain and bloody stools.An initial biopsy showed cecal cancer;however,subsequent colonoscopy and computed tomography findings raised the suspicion of appendiceal intussus-ception,which was later confirmed postoperatively.This unique case was charac-terized by a combination of intussusception and adenocarcinoma of the cecum.The intervention included a laparoscopic right hemicolectomy,which led to the histopathological diagnosis of mucinous adenocarcinoma with appendiceal intussusception.The patient recovered well postoperatively and was advised to initiate adjuvant chemotherapy.This case highlights not only the importance of considering appendiceal intussusception in the differential diagnosis,but also the possibility of appendicitis and the atypical presentation of neoplastic lesions.CONCLUSIONS Physicians should consider the possibility of appendiceal intussusception in cases of atypical appendicitis,particularly when associated with neoplastic presentation.

Effects of vacancy and external electric field on the electronic properties of the MoSi_(2)N_(4)/graphene heterostructure

Recently,the newly synthesized septuple-atomic layer two-dimensional(2D)material MoSi_(2)N_(4)(MSN)has attracted attention worldwide.Our work delves into the effect of vacancies and external electric fields on the electronic properties of the MSN/graphene(Gr)heterostructure using first-principles calculation.We find that four types of defective structures,N-in,N-out,Si and Mo vacancy defects of monolayer MSN and MSN/Gr heterostructure are stable in air.Moreover,vacancy defects can effectively modulate the charge transfer at the interface of the MSN/Gr heterostructure as well as the work function of the pristine monolayer MSN and MSN/Gr heterostructure.Finally,the application of an external electric field enables the dynamic switching between n-type and p-type Schottky contacts.Our work may offer the possibility of exceeding the capabilities of conventional Schottky diodes based on MSN/Gr heterostructures.

Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome

Ulcerative colitis(UC)is a chronic recurrent inflammatory bowel disease.Despite ongoing advances in our understanding of UC,its pathogenesis is yet unelu-cidated,underscoring the urgent need for novel treatment strategies for patients with UC.Exosomes are nanoscale membrane particles that mediate intercellular communication by carrying various bioactive molecules,such as proteins,RNAs,DNA,and metabolites.The NOD-like receptor family pyrin domain containing 3(NLRP3)inflammasome is a cytosolic tripartite protein complex whose activation induces the maturation and secretion of proinflammatory cytokines interleukin-1β(IL-1β)and IL-18,triggering the inflammatory response to a pathogenic agent or injury.Growing evidence suggests that exosomes are new modulators of the NLRP3 inflammasome,with vital roles in the pathological process of UC.Here,recent evidence is reviewed on the role of exosomes and NLRP3 inflammasome in UC.First,the dual role of exosomes on NLRP3 inflammasome and the effect of NLRP3 inflammasome on exosome secretion are summarized.Finally,an outlook on the directions of exosome-NLRP3 inflammasome crosstalk research in the context of UC is proposed and areas of further research on this topic are high-lighted.

Synergy of heterogeneous Co/Ni dual atoms enabling selective C-O bond scission of lignin coupling with in-situ N-functionalization

Selective cleavage of Csp^(2)-OCH_(3)bond in lignin without breaking other types of C-O bonds followed by N-functionalization is fascinating for on-purpose valorization of biomass.Here,a Co/Ni-based dual-atom catalyst CoNiDA@NC prepared by in-situ evaporation and acid-etching of metal species from tailor-made metal–organic frameworks was efficient for reductive upgrading of various lignin-derived phenols to cyclohexanols(88.5%–99.9%yields),which had ca.4 times higher reaction rate than the single-atom catalyst and was superior to state-of-the-art heterogeneous catalysts.The synergistic catalysis of Co/Ni dual atoms facilitated both hydrogen dissociation and hydrogenolysis steps,and could optimize adsorption configuration of lignin-derived methoxylated phenols to further favor the Csp^(2)-OCH_(3)cleavage,as elaborated by theoretical calculations.Notably,the CoNi_(DA)@NC catalyst was highly recyclable,and exhibited excellent demethoxylation performance(77.1%yield)in real lignin monomer mixtures.Via in-situ cascade conversion processes assisted by dual-atom catalysis,various high-value N-containing chemicals,including caprolactams and cyclohexylamines,could be produced from lignin.

Selenium Differentially Regulates Flavonoid Accumulation and Antioxidant Capacities in Sprouts of Twenty Diverse Mungbean(Vigna radiata(L.)Wilczek)Genotypes

Seed germination with selenium(Se)is promising for producing Se-biofortified foods.Mungbean(Vigna radiata(L.)Wilczek)sprout is freshly eaten as a salad dressed with sauce,making it superior for Se biofortification.Since the Se safety range for the human body is extremely narrow,it is imperative to evaluate the genotypic responses of mungbean sprouts to Se.This study evaluated the Se enrichment capacity and interaction withflavonoids and antioxidant systems in sprouts of 20 mungbean germplasms.Selenium treatment was done by immersing mung-bean seeds in 20μM sodium selenite solution for 8 h.Afterward,the biomass,Se amounts,flavonoid(particularly vitexin and isovitexin)contents,antioxidant capacity,and key biosynthetic gene expressions were measured.Sprout Se content was 2.0-7.0μg g^(-1) DW among the 20 mungbean germplasms.Selenium treatment differentially affected the biomass,totalflavonoid,vitexin,isovitexin,antioxidant enzyme activities,and antioxidant capacities of the mungbean germplasms.Eight germplasms showed increased biomass(p<0.05),the highest increasing by 127%,but 13 did not phenotypically respond to Se treatment.Seven and six germplasms showed varied levels of vitexin and isovitexin increment after Se treatment,the highest measuring 2.67-and 2.87-folds for vitexin and isovitexin,respectively.Two mungbeanflavonoid biosynthesis genes,chalcone synthase(VrCHS)and chalcone isomerase(VrCHI)were significantly up-regulated in the germplasms with increased vitexin and isovitexin levels(p<0.05).Moreover,Se enrichment capacity was significantly correlated with the vitexin,isovitexin,and antiox-idant capacities.In conclusion,mungbean sprouts could be a useful Se-biofortified food,but the Se enrichment capacity and nutritional response must be determined for each germplasm before commercialization.