The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid...The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid (1) in the presence of palladium complexes catalyst. Selective hydroboration and oxidation of 2 by Ca(BH 4) 2/H 2O 2 system gave 8(Z)-heptadecen-1-ol (3), which then was acetylized by treatment with Ac 2O/pyridine to afford 8(Z)-heptadecen-ol acetate(4). The compound 4 was ozonized to form the key intermediate 8-acetoxyoctanal (5), then compound 5 was coupled with the Wittig regents to obtain the title compound 8(Z/E)dodecen-1-ol acetate (6), Z/E molar ratio is 25∶75. The overall yield was 45%. The structures of all the compounds were confirmed by IR, MS and NMR spectra.展开更多
Title Compond-5 chloro 2,4,6 trifluoro 1,3 bezenedicarbonitrile was prepared by fluoration exchange reaction under comparatively mild condition with yield 81%;various reactive conditions,as well as its possible by pro...Title Compond-5 chloro 2,4,6 trifluoro 1,3 bezenedicarbonitrile was prepared by fluoration exchange reaction under comparatively mild condition with yield 81%;various reactive conditions,as well as its possible by products,were discussed in detail.The structure of the target compound was confirmed by excluding its two isomers based on IR,MS, 13 CNMR,and 19 FNMR data.展开更多
This paper reported the aminolysis of colchicine and antitumor activity of its derivatives.The results of leukeamia K562 cell growth inhibition tests in vitro showed that all derivatives had moderate antitumor activit...This paper reported the aminolysis of colchicine and antitumor activity of its derivatives.The results of leukeamia K562 cell growth inhibition tests in vitro showed that all derivatives had moderate antitumor activities and no cytotoxic activity to SGC 7901 cell line.展开更多
Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be...Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.展开更多
Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of...Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of α methylene 3 pentanone(4) with silylenol ether(2). In the presence of chiral reagent 6 β phenyl amino 3 β,5α chlorestandiol(7), compound (5) was reduced by KBH 4 directly to give Tobacco Beetle Pheromone (7S) (-) 4,6 dimethyl 7 hydroxyl 3 nonanone(6). 25 D=-35 87°( c =0 23, CHCl 3), overall yield 23 9%.展开更多
文摘The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid (1) in the presence of palladium complexes catalyst. Selective hydroboration and oxidation of 2 by Ca(BH 4) 2/H 2O 2 system gave 8(Z)-heptadecen-1-ol (3), which then was acetylized by treatment with Ac 2O/pyridine to afford 8(Z)-heptadecen-ol acetate(4). The compound 4 was ozonized to form the key intermediate 8-acetoxyoctanal (5), then compound 5 was coupled with the Wittig regents to obtain the title compound 8(Z/E)dodecen-1-ol acetate (6), Z/E molar ratio is 25∶75. The overall yield was 45%. The structures of all the compounds were confirmed by IR, MS and NMR spectra.
文摘Title Compond-5 chloro 2,4,6 trifluoro 1,3 bezenedicarbonitrile was prepared by fluoration exchange reaction under comparatively mild condition with yield 81%;various reactive conditions,as well as its possible by products,were discussed in detail.The structure of the target compound was confirmed by excluding its two isomers based on IR,MS, 13 CNMR,and 19 FNMR data.
文摘This paper reported the aminolysis of colchicine and antitumor activity of its derivatives.The results of leukeamia K562 cell growth inhibition tests in vitro showed that all derivatives had moderate antitumor activities and no cytotoxic activity to SGC 7901 cell line.
文摘Chlorothalonil 1 was treated with anhydrous KF in DMF at 110 ℃ to give the corresponding crystalline fluorine-containing 1,3-benzenedicarbonitrile 2. KF was used in an equivalent to the number of chlorine atoms to be substituted. Compound 2 was subsequently reacted with ammonia to yield compound 3. In addition, halobenzamide 4 were refluxed with oxalyl chloride in anhydrous 1,2-dichloroethane(DCE) to yield benzoylisocyanates 5. Finally, seven novel BPUs chitin inhibitors 6a—6g were synthesized via the selective reaction of compound 3 with benzoylisocyanate derivatives 5, the total yield is over 30%—50%.
文摘Using an available compound 3 pentanone(1) as starting material, the key intermediate compound 4,6 dimethyl 3,7 nonandione(5) was synthesized through the addition elimination of silylenol ether and Michael addition of α methylene 3 pentanone(4) with silylenol ether(2). In the presence of chiral reagent 6 β phenyl amino 3 β,5α chlorestandiol(7), compound (5) was reduced by KBH 4 directly to give Tobacco Beetle Pheromone (7S) (-) 4,6 dimethyl 7 hydroxyl 3 nonanone(6). 25 D=-35 87°( c =0 23, CHCl 3), overall yield 23 9%.
