目的:考察125I-(a-cobratoxin,Nt)透鼻黏膜吸收的情况及冰片的促进作用。方法:以大鼠、家兔、狗和羊为研究对象,以放射性活性(每分钟计数,count per minute,cpm)为指标,采用离体渗透鼻黏膜实验、在体渗透鼻黏膜重循环实验等方法,研究125...目的:考察125I-(a-cobratoxin,Nt)透鼻黏膜吸收的情况及冰片的促进作用。方法:以大鼠、家兔、狗和羊为研究对象,以放射性活性(每分钟计数,count per minute,cpm)为指标,采用离体渗透鼻黏膜实验、在体渗透鼻黏膜重循环实验等方法,研究125I-Nt对不同动物透鼻黏膜吸收的情况及冰片的促进作用。结果:研究发现,Nt很难透过鼻黏膜吸收,但在冰片作用下吸收显著增加。结论:冰片对Nt透鼻黏膜吸收有显著促进作用。展开更多
Beer’s law experiment, variable-temperature spectral experiment of UV-Vis absorption,H NMR, and measurement of magnetic moment were conducted for NiTMPyP in aqueous solution. It was found that Beer’s law was obeyed ...Beer’s law experiment, variable-temperature spectral experiment of UV-Vis absorption,H NMR, and measurement of magnetic moment were conducted for NiTMPyP in aqueous solution. It was found that Beer’s law was obeyed in concentration range 8 x 10-7-2 x 10-5.mol’dm-3.With the temperature increasing from 0 ℃ to 95 ℃, the isosbestic point appeared at 435 nmand the lowest downfield H NMR peak narrowed gradually and shifted to upfield. The magneticmoment is 2.07 BM in D2O at 30 ℃, but in the D2O-CD3COCD3 mised solvent there was noevidence for the existance of paramagnetic species. These results show that NiTMPyP exists inaqueous solution as an equilibrium mixture of diamagnetic, four-coordinate nickel (Ⅱ) and paramagnetic, sir-coordinate nickel (Ⅱ) complexed by water molecules in the axial position. Thethermodynamic parameters of the edal-coordinated reaction展开更多
文摘目的:考察125I-(a-cobratoxin,Nt)透鼻黏膜吸收的情况及冰片的促进作用。方法:以大鼠、家兔、狗和羊为研究对象,以放射性活性(每分钟计数,count per minute,cpm)为指标,采用离体渗透鼻黏膜实验、在体渗透鼻黏膜重循环实验等方法,研究125I-Nt对不同动物透鼻黏膜吸收的情况及冰片的促进作用。结果:研究发现,Nt很难透过鼻黏膜吸收,但在冰片作用下吸收显著增加。结论:冰片对Nt透鼻黏膜吸收有显著促进作用。
文摘Beer’s law experiment, variable-temperature spectral experiment of UV-Vis absorption,H NMR, and measurement of magnetic moment were conducted for NiTMPyP in aqueous solution. It was found that Beer’s law was obeyed in concentration range 8 x 10-7-2 x 10-5.mol’dm-3.With the temperature increasing from 0 ℃ to 95 ℃, the isosbestic point appeared at 435 nmand the lowest downfield H NMR peak narrowed gradually and shifted to upfield. The magneticmoment is 2.07 BM in D2O at 30 ℃, but in the D2O-CD3COCD3 mised solvent there was noevidence for the existance of paramagnetic species. These results show that NiTMPyP exists inaqueous solution as an equilibrium mixture of diamagnetic, four-coordinate nickel (Ⅱ) and paramagnetic, sir-coordinate nickel (Ⅱ) complexed by water molecules in the axial position. Thethermodynamic parameters of the edal-coordinated reaction