测序技术的发展证实意义不明克隆性造血(clonal hematopoiesis of indeterminate potential,CHIP)是老年相关的普遍现象,是体细胞突变在造血系统中的表现。最常见的突变基因DNMT3A、TET2、ASXL1和JAK2与髓系肿瘤相关,临床表现多为不明...测序技术的发展证实意义不明克隆性造血(clonal hematopoiesis of indeterminate potential,CHIP)是老年相关的普遍现象,是体细胞突变在造血系统中的表现。最常见的突变基因DNMT3A、TET2、ASXL1和JAK2与髓系肿瘤相关,临床表现多为不明原因的血细胞减少以及髓系疾病的前期状态。近年来的临床观察和动物实验研究表明,CHIP还与动脉粥样硬化、心血管病等常见病相关,增加总体病死率。对克隆性造血机制的初步研究表明,体细胞基因突变是意义不明克隆性造血的基础,为髓系恶性疾病和心血管疾病的防治研究提供了新的线索,日益受到关注。本文综述了意义不明克隆性造血的机制及其意义。展开更多
In these two decades more cytokines and their receptors arise involving hemopoiesis, not only colony stimulating factors, int erleukins and growth factors but also chemokines etc. Some novel cytokines wer e discovered...In these two decades more cytokines and their receptors arise involving hemopoiesis, not only colony stimulating factors, int erleukins and growth factors but also chemokines etc. Some novel cytokines wer e discovered as the ligand of “orphan receptor” e.g. FL and KL, which played c ritical role for proliferation of stem cell and progenitors. On the other hand, novel cytokine or cytokine receptor were encoded by some viruses- “virokine” o r “viroceptor” also reported in last decade.展开更多
文摘测序技术的发展证实意义不明克隆性造血(clonal hematopoiesis of indeterminate potential,CHIP)是老年相关的普遍现象,是体细胞突变在造血系统中的表现。最常见的突变基因DNMT3A、TET2、ASXL1和JAK2与髓系肿瘤相关,临床表现多为不明原因的血细胞减少以及髓系疾病的前期状态。近年来的临床观察和动物实验研究表明,CHIP还与动脉粥样硬化、心血管病等常见病相关,增加总体病死率。对克隆性造血机制的初步研究表明,体细胞基因突变是意义不明克隆性造血的基础,为髓系恶性疾病和心血管疾病的防治研究提供了新的线索,日益受到关注。本文综述了意义不明克隆性造血的机制及其意义。
文摘In these two decades more cytokines and their receptors arise involving hemopoiesis, not only colony stimulating factors, int erleukins and growth factors but also chemokines etc. Some novel cytokines wer e discovered as the ligand of “orphan receptor” e.g. FL and KL, which played c ritical role for proliferation of stem cell and progenitors. On the other hand, novel cytokine or cytokine receptor were encoded by some viruses- “virokine” o r “viroceptor” also reported in last decade.
