[Objective] The aim of this study is to evaluate the safety and bacteriostasis of Yandureqing(AEE)and its microemulsion(AEE-ME).[Method]The acute toxicity was tested in mice by intragastric administration,and median l...[Objective] The aim of this study is to evaluate the safety and bacteriostasis of Yandureqing(AEE)and its microemulsion(AEE-ME).[Method]The acute toxicity was tested in mice by intragastric administration,and median lethal dose(LD50)as well as its 95% confidence interval was calculated by modified Karber method;the bacteriostasis was investigated by cylinder plate method.[Result]LD50 of AEE in mice was 10.937 g/kg with the 95% confidence interval of 9.309-12.850 g/kg;and LD50 of AEE-ME in mice was 5.357 g/kg with the 95% confidence interval of 4.388-6.566 g/kg.The MICs of AEE to Escherichia coli O149 from swine,Staphylococcus aureus,Salmonella pullorum and Streptococcus agalactiae were 10.00,20.00,20.00 and 10.00 mg/ml,respectively;while the MICs of AEE-ME to the 4 kinds of bacteria mentioned above were 5.00,10.00,5.00 and 5.00 mg/ml in turn,and that to Pseudomonas aeruginosa is 20.00 mg/ml.[Conclusion]AEE is an actually nontoxic drug and AEE-ME belongs to the low toxic preparation.AEE and AEE-ME have obvious bacteriostasis,in which AEE-ME is superior to AEE.展开更多
Parasitic disease is one of the most serious diseases in humans and animals. Animal antiparasitic drugs are mainly used to kill, expel and prevent animal parasites, and they are divided into anthelmintics, antiprotozo...Parasitic disease is one of the most serious diseases in humans and animals. Animal antiparasitic drugs are mainly used to kill, expel and prevent animal parasites, and they are divided into anthelmintics, antiprotozoals, insecticides, and so on. Animal antiparasitic drugs play an important role in the prevention and control of animal parasitic diseases, healthy development of animal husbandry and security of public health. In recent years, as people pay more attention paid to parasitic diseases, the research and development of antiparasitic drugs have made great progresses. Mastering the research and application progresses of antiparasitic drugs is of great significance to clinical medication and basic research. This paper reviews the history, current situation, the latest progresses and future development directions of research and application of antiparasitic drugs.展开更多
基金Supported by Specific Program Funded by Basic Scientific Research Operating Expenses of Central Public Scientific Research Institutes(BRF060403)Key Project of Scientific and Technical Supporting Pro-grams of Gansu Province(0804NKCA074)~~
文摘[Objective] The aim of this study is to evaluate the safety and bacteriostasis of Yandureqing(AEE)and its microemulsion(AEE-ME).[Method]The acute toxicity was tested in mice by intragastric administration,and median lethal dose(LD50)as well as its 95% confidence interval was calculated by modified Karber method;the bacteriostasis was investigated by cylinder plate method.[Result]LD50 of AEE in mice was 10.937 g/kg with the 95% confidence interval of 9.309-12.850 g/kg;and LD50 of AEE-ME in mice was 5.357 g/kg with the 95% confidence interval of 4.388-6.566 g/kg.The MICs of AEE to Escherichia coli O149 from swine,Staphylococcus aureus,Salmonella pullorum and Streptococcus agalactiae were 10.00,20.00,20.00 and 10.00 mg/ml,respectively;while the MICs of AEE-ME to the 4 kinds of bacteria mentioned above were 5.00,10.00,5.00 and 5.00 mg/ml in turn,and that to Pseudomonas aeruginosa is 20.00 mg/ml.[Conclusion]AEE is an actually nontoxic drug and AEE-ME belongs to the low toxic preparation.AEE and AEE-ME have obvious bacteriostasis,in which AEE-ME is superior to AEE.
基金Supported by Earmarked Fund for China Agriculture Research System(CAR-38)Twelfth Five-Year National Key Technology Research and Development Program(2015BAD1101)~~
文摘Parasitic disease is one of the most serious diseases in humans and animals. Animal antiparasitic drugs are mainly used to kill, expel and prevent animal parasites, and they are divided into anthelmintics, antiprotozoals, insecticides, and so on. Animal antiparasitic drugs play an important role in the prevention and control of animal parasitic diseases, healthy development of animal husbandry and security of public health. In recent years, as people pay more attention paid to parasitic diseases, the research and development of antiparasitic drugs have made great progresses. Mastering the research and application progresses of antiparasitic drugs is of great significance to clinical medication and basic research. This paper reviews the history, current situation, the latest progresses and future development directions of research and application of antiparasitic drugs.
