目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、...目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、拉莫三嗪、左乙拉西坦及苯妥英钠。ADR以神经系统最为常见,主要表现为头晕、嗜睡、头痛等,其次为肝胆、胃肠及代谢系统疾病。结论:临床应关注抗癫痫药ADR,加强用药监测。展开更多
随着科学教育改革的不断深入,人们愈来愈重视学生科学身份认同问题,并将其作为科学素养的重要组成部分和科学教育的重要目标。早在2008年,美国国家研究理事会《把科学带进学校》(Tak⁃ing Science to School)就明确将“发展科学兴趣、理...随着科学教育改革的不断深入,人们愈来愈重视学生科学身份认同问题,并将其作为科学素养的重要组成部分和科学教育的重要目标。早在2008年,美国国家研究理事会《把科学带进学校》(Tak⁃ing Science to School)就明确将“发展科学兴趣、理解科学知识、从事科学推理、反思科学、参与科学实践和科学身份认同(Science Identity)”作为科学教育的目标,[1]其中,科学身份认同既是个体长期参与各种科学活动的结果,也是前五方面的凝结。展开更多
目的:基于美国食品药品监督管理局公共数据公开项目(OpenFDA)数据库,挖掘拉考沙胺相关药物不良反应(adverse drug reactions,ADRs)的临床特点,为临床拉考沙胺的用药安全提供参考。方法:以“拉考沙胺(lacosamide)”作为检索词,在OpenFDA...目的:基于美国食品药品监督管理局公共数据公开项目(OpenFDA)数据库,挖掘拉考沙胺相关药物不良反应(adverse drug reactions,ADRs)的临床特点,为临床拉考沙胺的用药安全提供参考。方法:以“拉考沙胺(lacosamide)”作为检索词,在OpenFDA数据库中检索2004年1月1日—2023年2月1日拉考沙胺相关ADRs的所有信息,分析其流行病学特点。结果:在OpenFDA数据库中共检索到拉考沙胺相关ADRs 10510例,其中2018年起上报数量明显增多;10510例拉考沙胺相关ADRs中,绝大多数ADRs的严重程度为“严重”(9170例,占87.25%)“,一般”的仅1340例(占12.75%);拉考沙胺相关ADRs主要表现为各类神经系统症状,其次为全身性或给药部位的不适或异常和精神类症状;在10510例拉考沙胺相关ADRs中,有1011例的最终结局是死亡,有76例则留有后遗症。结论:拉考沙胺相关ADRs大多表现较为严重,甚至有不少致死的情况,因此临床在使用拉考沙胺进行治疗时应加强用药监护,以避免或减少严重不良结局的发生。展开更多
The study of nonlinear optical responses in the mid-infrared(mid-IR)regime is essential for advancing ultrafast mid-IR laser applications.However,nonlinear optical effects under mid-IR excitation are rarely reported d...The study of nonlinear optical responses in the mid-infrared(mid-IR)regime is essential for advancing ultrafast mid-IR laser applications.However,nonlinear optical effects under mid-IR excitation are rarely reported due to the lack of suitable nonlinear optical materials.The natural van derWaals heterostructure franckeite,known for its narrow bandgap and stability in air,shows great potential for developing mid-IR nonlinear optical devices.We have experimentally demonstrated that layered franckeite exhibits a broadband wavelength-dependent nonlinear optical response in the mid-IR spectral region.Franckeite nanosheets were prepared using a liquid-phase exfoliation method,and their nonlinear optical response was characterized in the spectral range of 3000 nm to 5000 nm.The franckeite nanosheets exhibit broadband wavelengthdependent third-order nonlinearities,with nonlinear absorption and refraction coefficients estimated to be about 10^(-7)cm/W and 10^(-11)cm^(2)/W,respectively.Additionally,a passively Q-switched fluoride fiber laser operating around a wavelength of 2800 nm was achieved,delivering nanosecond pulses with a signal-to-noise ratio of 43.6 dB,based on the nonlinear response of franckeite.These findings indicate that layered franckeite possesses broadband nonlinear optical characteristics in the mid-IR region,potentially enabling new possibilities for mid-IR photonic devices.展开更多
目的:比较腹主动脉球囊阻断术与子宫动脉栓塞术在植入型凶险性前置胎盘剖宫产术中的治疗效果。方法:回顾性分析近3年我院收治的42例凶险性前置胎盘伴胎盘植入患者的临床资料,剖宫产术中采用子宫动脉栓塞术治疗者24例,采用腹主动脉球囊...目的:比较腹主动脉球囊阻断术与子宫动脉栓塞术在植入型凶险性前置胎盘剖宫产术中的治疗效果。方法:回顾性分析近3年我院收治的42例凶险性前置胎盘伴胎盘植入患者的临床资料,剖宫产术中采用子宫动脉栓塞术治疗者24例,采用腹主动脉球囊阻断术者18例,观察比较两组患者术中术后情况及新生儿出生情况。结果:腹主动脉球囊阻断术组患者术中出血量、输红细胞悬液量、手术时间、辐射时间、辐射剂量、术后住院时间、并发症、转重症监护室(ICU)率均少于子宫动脉栓塞术组,差异具有统计学意义(P <0.05);两组子宫切除率、新生儿出生体重、1 min Apgar评分、新生儿窒息率及转新生儿重症监护室(NICU)率比较,差异无统计学意义(P> 0.05)。结论:与子宫动脉栓塞术比较,腹主动脉球囊阻断术在植入型凶险性前置胎盘剖宫产术中具有更显著的优势。展开更多
文摘目的:了解抗癫痫药物不良反应(adverse drug reaction,ADR)的发生规律及特点。方法:提取我院上报至国家药品不良反应监测系统的抗癫痫药ADR报告进行分析。结果:共收集69例抗癫痫药ADR,涉及药品6种,包括丙戊酸钠、奥卡西平、卡马西平、拉莫三嗪、左乙拉西坦及苯妥英钠。ADR以神经系统最为常见,主要表现为头晕、嗜睡、头痛等,其次为肝胆、胃肠及代谢系统疾病。结论:临床应关注抗癫痫药ADR,加强用药监测。
文摘随着科学教育改革的不断深入,人们愈来愈重视学生科学身份认同问题,并将其作为科学素养的重要组成部分和科学教育的重要目标。早在2008年,美国国家研究理事会《把科学带进学校》(Tak⁃ing Science to School)就明确将“发展科学兴趣、理解科学知识、从事科学推理、反思科学、参与科学实践和科学身份认同(Science Identity)”作为科学教育的目标,[1]其中,科学身份认同既是个体长期参与各种科学活动的结果,也是前五方面的凝结。
文摘目的:基于美国食品药品监督管理局公共数据公开项目(OpenFDA)数据库,挖掘拉考沙胺相关药物不良反应(adverse drug reactions,ADRs)的临床特点,为临床拉考沙胺的用药安全提供参考。方法:以“拉考沙胺(lacosamide)”作为检索词,在OpenFDA数据库中检索2004年1月1日—2023年2月1日拉考沙胺相关ADRs的所有信息,分析其流行病学特点。结果:在OpenFDA数据库中共检索到拉考沙胺相关ADRs 10510例,其中2018年起上报数量明显增多;10510例拉考沙胺相关ADRs中,绝大多数ADRs的严重程度为“严重”(9170例,占87.25%)“,一般”的仅1340例(占12.75%);拉考沙胺相关ADRs主要表现为各类神经系统症状,其次为全身性或给药部位的不适或异常和精神类症状;在10510例拉考沙胺相关ADRs中,有1011例的最终结局是死亡,有76例则留有后遗症。结论:拉考沙胺相关ADRs大多表现较为严重,甚至有不少致死的情况,因此临床在使用拉考沙胺进行治疗时应加强用药监护,以避免或减少严重不良结局的发生。
基金supported by the National Natural Science Foundation of China(Grant No.61975055)the Natural Science Foundation of Hunan Province,China(Grant No.2023JJ30165)+1 种基金the Natural Science Foundation of Shandong Province,China(Grant No.ZR2022QF005)the Doctoral Fund of University of Heze(Grant No.XY22BS14).
文摘The study of nonlinear optical responses in the mid-infrared(mid-IR)regime is essential for advancing ultrafast mid-IR laser applications.However,nonlinear optical effects under mid-IR excitation are rarely reported due to the lack of suitable nonlinear optical materials.The natural van derWaals heterostructure franckeite,known for its narrow bandgap and stability in air,shows great potential for developing mid-IR nonlinear optical devices.We have experimentally demonstrated that layered franckeite exhibits a broadband wavelength-dependent nonlinear optical response in the mid-IR spectral region.Franckeite nanosheets were prepared using a liquid-phase exfoliation method,and their nonlinear optical response was characterized in the spectral range of 3000 nm to 5000 nm.The franckeite nanosheets exhibit broadband wavelengthdependent third-order nonlinearities,with nonlinear absorption and refraction coefficients estimated to be about 10^(-7)cm/W and 10^(-11)cm^(2)/W,respectively.Additionally,a passively Q-switched fluoride fiber laser operating around a wavelength of 2800 nm was achieved,delivering nanosecond pulses with a signal-to-noise ratio of 43.6 dB,based on the nonlinear response of franckeite.These findings indicate that layered franckeite possesses broadband nonlinear optical characteristics in the mid-IR region,potentially enabling new possibilities for mid-IR photonic devices.
文摘目的:比较腹主动脉球囊阻断术与子宫动脉栓塞术在植入型凶险性前置胎盘剖宫产术中的治疗效果。方法:回顾性分析近3年我院收治的42例凶险性前置胎盘伴胎盘植入患者的临床资料,剖宫产术中采用子宫动脉栓塞术治疗者24例,采用腹主动脉球囊阻断术者18例,观察比较两组患者术中术后情况及新生儿出生情况。结果:腹主动脉球囊阻断术组患者术中出血量、输红细胞悬液量、手术时间、辐射时间、辐射剂量、术后住院时间、并发症、转重症监护室(ICU)率均少于子宫动脉栓塞术组,差异具有统计学意义(P <0.05);两组子宫切除率、新生儿出生体重、1 min Apgar评分、新生儿窒息率及转新生儿重症监护室(NICU)率比较,差异无统计学意义(P> 0.05)。结论:与子宫动脉栓塞术比较,腹主动脉球囊阻断术在植入型凶险性前置胎盘剖宫产术中具有更显著的优势。
