A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-...A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-ESI mass spectrometry analysis. The molecular structure was determined by single-crystal X-ray diffraction analysis. The in vitro anticancer activities of the complex have been evaluated against two human cancer cell lines(SGC-7901, BEL-7404), and the IC50 values are 32.5 and 57 μM, respectively.展开更多
A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the compl...A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the complete structure of 2 was determined by single-crystal X-ray diffraction analysis. Density functional theory(DFT) calculations with B3LYP functional and LANL2DZ(for Ru)/6-31G*(for other atoms) basis sets were carried out for the reactions involving complexes 1 and 2 in order to understand the formation of the complexes. The in vitro anticancer activities of the compound were investigated against five human cancer cell lines(SGC-7901, CNE-2, HepG2, KB and HeLa), and the IC50 values are 39.5, 45.8, 49.8, 54.5 and 61.8 μM, respectively.展开更多
基金Supported by the National Natural Science Foundation of China(21761006)Guangxi Natural Science Foundation(2016GXNSFCA380013,2017GXNSFAA198335,2018GXNSFAA281345)+3 种基金Guangxi Scientific and Technological Development Projects(AD17195081),“BAGUI Scholar” Program of Guangxi Province of China,Guangxi Key Laboratory of Natural Polymer Chemistry and Physics and Nanning Normal University,Natural Science Foundation of Guangxi University of Chinese Medicine(2017JQ001)Natural Science Foundation of Team of Professor Shilin Yang(YSL17004)the specific subject of the dominant discipline construction of Chinese pharmacy from Guangxi University of Chinese Medicine(ZYX2017003)Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine,Collaborative Innovation Center of Zhuang and Yao Ethnic Medicine,Guangxi Key Discipline(Zhuang Pharmacology)
文摘A Ru-arene compound containing two thiosemicarbazone ligands [(η6-p-cymene)Ru(TSC)2 Cl]Cl(1, TSC = benzophenone 4-methylthiosemicarbazone) has been synthesized and characterized by 1 H NMR, elemental analysis and HR-ESI mass spectrometry analysis. The molecular structure was determined by single-crystal X-ray diffraction analysis. The in vitro anticancer activities of the complex have been evaluated against two human cancer cell lines(SGC-7901, BEL-7404), and the IC50 values are 32.5 and 57 μM, respectively.
基金supported by the National Natural Science Foundation of China (51961009,21761006)Natural Science Foundation of Guangxi Province (2017GXNSFAA198335,2018GXNSFAA281345)+5 种基金Guangxi Scientific and Technological Development Projects (AD17195081)“BAGUI Scholar” Program of Guangxi ProvinceNatural Science Foundation of Guangxi University of Chinese Medicine (2017JQ001)Guangxi First-class Discipline Chinese Materia Medica (Scientific Research of Guangxi Education Department 2018 No. 12)Research Project of Guangxi First-class Discipline (2019XK135)Project of Guangxi Key Laboratory of Zhuang and Yao Ethnic Medicine (GXZYZZ2019-4)。
文摘A new di-nuclear ruthenium arene compound containing thiosemicarbazone ligands, [Ru(η6-cymene)(TSC)Cl]2(PF6)2(2), was synthesized and characterized by 1H NMR, HR-ESI-MS, and elemental analysis. Furthermore, the complete structure of 2 was determined by single-crystal X-ray diffraction analysis. Density functional theory(DFT) calculations with B3LYP functional and LANL2DZ(for Ru)/6-31G*(for other atoms) basis sets were carried out for the reactions involving complexes 1 and 2 in order to understand the formation of the complexes. The in vitro anticancer activities of the compound were investigated against five human cancer cell lines(SGC-7901, CNE-2, HepG2, KB and HeLa), and the IC50 values are 39.5, 45.8, 49.8, 54.5 and 61.8 μM, respectively.
