精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助...精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助生殖技术结局存在负相关,SDF检测已在男性不育症和辅助生殖技术中得到越来越广泛的应用。本专家共识复习和评估了SDF相关文献,对SDF的危险因素、检测方法、临床意义和处理等提出2项良好实践要点和9项推荐建议。本共识大部分推荐建议的证据和级别属于低或中等,表明仍需要进一步的研究证实临床应用SDF检测的价值。展开更多
To investigate the effects of the down-regulation on quality of oocyte.The protocols,age,down-regulation days before Gn and the level of LH on the day of hCG injection are not significantly related to the rate of norm...To investigate the effects of the down-regulation on quality of oocyte.The protocols,age,down-regulation days before Gn and the level of LH on the day of hCG injection are not significantly related to the rate of normal fertilization and cleavage.The age between 25-35 years old and LH≤5 IU/L on the day of hCG injection,have higher rate of good-quality embryo,embryo implantation and pregrancy.The embryo’s aneuploid rate is higher when the age raise up.The number of retrieval oocyte don’t affect the embryo’s aneuploid rate.The way of insemination and control ovarian stimulation protocols affect the embryo’s aneuploid rate.展开更多
文摘精子DNA碎片(sperm DNA fragmentation,SDF)在男性不育症中发生率较高。SDF常伴发少、弱精子症,也可发生于常规精液指标正常的不育症患者。其发生机制包括精子成熟障碍、凋亡异常和氧化应激过高等。由于很多文献报道其与自然妊娠和辅助生殖技术结局存在负相关,SDF检测已在男性不育症和辅助生殖技术中得到越来越广泛的应用。本专家共识复习和评估了SDF相关文献,对SDF的危险因素、检测方法、临床意义和处理等提出2项良好实践要点和9项推荐建议。本共识大部分推荐建议的证据和级别属于低或中等,表明仍需要进一步的研究证实临床应用SDF检测的价值。
文摘To investigate the effects of the down-regulation on quality of oocyte.The protocols,age,down-regulation days before Gn and the level of LH on the day of hCG injection are not significantly related to the rate of normal fertilization and cleavage.The age between 25-35 years old and LH≤5 IU/L on the day of hCG injection,have higher rate of good-quality embryo,embryo implantation and pregrancy.The embryo’s aneuploid rate is higher when the age raise up.The number of retrieval oocyte don’t affect the embryo’s aneuploid rate.The way of insemination and control ovarian stimulation protocols affect the embryo’s aneuploid rate.