目的红景天苷(Sal)是藏药红景天的主要活性成分,具有良好的抗凋亡潜能。目前,关于Sal的抗凋亡机制研究存在一些相互矛盾的结果。我们以Sal在缺氧缺血性脑损伤(HICD)中的作用为例,进行了系统综述和荟萃分析,以提供Sal在预防和治疗HICD中...目的红景天苷(Sal)是藏药红景天的主要活性成分,具有良好的抗凋亡潜能。目前,关于Sal的抗凋亡机制研究存在一些相互矛盾的结果。我们以Sal在缺氧缺血性脑损伤(HICD)中的作用为例,进行了系统综述和荟萃分析,以提供Sal在预防和治疗HICD中的临床前证据和抗凋亡特性。方法利用中文数据库中国知网(CNKI)、维普(VIP)、万方以及英文数据库PubMed和Web of Science在线检索1980年1月1日至2021年11月9日的有关Sal抗凋亡潜能治疗HICD的文献。采用Cochrane协作网偏倚风险评估标准评价纳入文献的质量,并利用RevMan 5.3软件进行Meta分析。结果最终纳入研究的文献有40篇。40篇文献中,动物实验30篇,体外细胞实验17篇,其中7篇既包含动物实验又包含细胞实验。经统计发现,Sal对HICD的脑梗死面积、脑含水量等疾病相关指标有明显改善作用(P<0.05)。在体内研究中,Sal主要通过抗炎、抗氧化、调节补体通路、信号转导和自噬等途径影响凋亡因子的表达,从而在治疗HICD疾病中发挥抗凋亡潜能。在体外研究中,Sal在HICD疾病模型中主要通过抗氧化、抗炎、改善Ca^(2+)超载、调节线粒体功能、信号转导和C3补体等途径发挥抗凋亡作用。结论Sal可通过抗炎、抗氧化、改善自噬、补体和信号转导、调节线粒体膜电位和改善Ca^(2+)过载等途径发挥抗凋亡作用,预防和治疗HICD疾病。展开更多
目的:探讨扎根理论在指导低年资护士照护有自杀倾向精神患者中的现状,为提升精神科护理服务质量、提高有自杀倾向患者的护理服务满意度提供参考。方法:对22名低年资护士进行半结构式深度访谈,收集低年资护士对精神病患者的认知、感受与...目的:探讨扎根理论在指导低年资护士照护有自杀倾向精神患者中的现状,为提升精神科护理服务质量、提高有自杀倾向患者的护理服务满意度提供参考。方法:对22名低年资护士进行半结构式深度访谈,收集低年资护士对精神病患者的认知、感受与需求等相关资料直至资料饱和,采用以扎根理论为基础的质性研究方法析取主题。结果:析出的主题为低年资护士照护有自杀倾向的精神科患者的实体理论,包括四个组成部分:因果关系、情景条件、干预条件、行动互动。每个组成部分可以分成多个条目和子条目。结果是低年资护士思维重构,自杀护理能力有所提升,同时精神病患者生理心理症状改善,接受生活现状,减少自杀念头。结论:扎根理论在低年资护士照护自杀倾向患者的实践中具有重要的应用价值,可引导护理人员根据有自杀倾向的精神病患者的护理诉求,建立有效的护理策略和方法,制订个体化护理服务计划,采取针对性、实用性的干预策略,以减少低年资护士对于照护精神病患者的情绪化行为,提升护理服务质量。Objective: To explore the current situation of grounded theory in guiding junior nurse to care for suicidal psychiatric patients, and to provide reference for improving the quality of psychiatric nursing services and improving the satisfaction of nursing services for suicidal psychiatric patients. Methods: A semi-structured in-depth interview was conducted with 22 junior nurse to collect their cognition, feelings and needs of psychiatric patients until the data was saturated. A qualitative research method based on grounded theory was adopted to extract the theme. Results: The theme was the entity theory of junior nurse caring for suicidal psychiatric patients. It included four components: causality, situational conditions, intervention conditions, and action interaction. Further, each component can be divided into multiple entries and sub-entries. The result was that the thinking mode of junior nurse was reconstructed, the ability of suicide nursing was improved. At the same time, the physiological and psychological symptoms of psychiatric patients were improved, and they accepted the life situation and reduced the suicidal thoughts. Conclusions: Grounded theory can guide nursing staff to make individualized nursing service plan according to the nursing demands of suicidal mental patients. The theory can also adopt targeted and practical intervention strategies, so as to reduce the emotional behavior of junior nurse for nursing mental patients, and improve the quality of nursing services.展开更多
基金supported by the National Natural Science Foundation of China(82104533 and 81973569)Xinglin Scholar Research Promotion Project of Chengdu University of TCM(XKTD2022013).
文摘目的红景天苷(Sal)是藏药红景天的主要活性成分,具有良好的抗凋亡潜能。目前,关于Sal的抗凋亡机制研究存在一些相互矛盾的结果。我们以Sal在缺氧缺血性脑损伤(HICD)中的作用为例,进行了系统综述和荟萃分析,以提供Sal在预防和治疗HICD中的临床前证据和抗凋亡特性。方法利用中文数据库中国知网(CNKI)、维普(VIP)、万方以及英文数据库PubMed和Web of Science在线检索1980年1月1日至2021年11月9日的有关Sal抗凋亡潜能治疗HICD的文献。采用Cochrane协作网偏倚风险评估标准评价纳入文献的质量,并利用RevMan 5.3软件进行Meta分析。结果最终纳入研究的文献有40篇。40篇文献中,动物实验30篇,体外细胞实验17篇,其中7篇既包含动物实验又包含细胞实验。经统计发现,Sal对HICD的脑梗死面积、脑含水量等疾病相关指标有明显改善作用(P<0.05)。在体内研究中,Sal主要通过抗炎、抗氧化、调节补体通路、信号转导和自噬等途径影响凋亡因子的表达,从而在治疗HICD疾病中发挥抗凋亡潜能。在体外研究中,Sal在HICD疾病模型中主要通过抗氧化、抗炎、改善Ca^(2+)超载、调节线粒体功能、信号转导和C3补体等途径发挥抗凋亡作用。结论Sal可通过抗炎、抗氧化、改善自噬、补体和信号转导、调节线粒体膜电位和改善Ca^(2+)过载等途径发挥抗凋亡作用,预防和治疗HICD疾病。
文摘目的:探讨扎根理论在指导低年资护士照护有自杀倾向精神患者中的现状,为提升精神科护理服务质量、提高有自杀倾向患者的护理服务满意度提供参考。方法:对22名低年资护士进行半结构式深度访谈,收集低年资护士对精神病患者的认知、感受与需求等相关资料直至资料饱和,采用以扎根理论为基础的质性研究方法析取主题。结果:析出的主题为低年资护士照护有自杀倾向的精神科患者的实体理论,包括四个组成部分:因果关系、情景条件、干预条件、行动互动。每个组成部分可以分成多个条目和子条目。结果是低年资护士思维重构,自杀护理能力有所提升,同时精神病患者生理心理症状改善,接受生活现状,减少自杀念头。结论:扎根理论在低年资护士照护自杀倾向患者的实践中具有重要的应用价值,可引导护理人员根据有自杀倾向的精神病患者的护理诉求,建立有效的护理策略和方法,制订个体化护理服务计划,采取针对性、实用性的干预策略,以减少低年资护士对于照护精神病患者的情绪化行为,提升护理服务质量。Objective: To explore the current situation of grounded theory in guiding junior nurse to care for suicidal psychiatric patients, and to provide reference for improving the quality of psychiatric nursing services and improving the satisfaction of nursing services for suicidal psychiatric patients. Methods: A semi-structured in-depth interview was conducted with 22 junior nurse to collect their cognition, feelings and needs of psychiatric patients until the data was saturated. A qualitative research method based on grounded theory was adopted to extract the theme. Results: The theme was the entity theory of junior nurse caring for suicidal psychiatric patients. It included four components: causality, situational conditions, intervention conditions, and action interaction. Further, each component can be divided into multiple entries and sub-entries. The result was that the thinking mode of junior nurse was reconstructed, the ability of suicide nursing was improved. At the same time, the physiological and psychological symptoms of psychiatric patients were improved, and they accepted the life situation and reduced the suicidal thoughts. Conclusions: Grounded theory can guide nursing staff to make individualized nursing service plan according to the nursing demands of suicidal mental patients. The theory can also adopt targeted and practical intervention strategies, so as to reduce the emotional behavior of junior nurse for nursing mental patients, and improve the quality of nursing services.
