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立体定向软通道颅内血肿清除术与内科保守治疗高血压性脑出血疗效的Meta分析 被引量:41
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作者 孟曙庆 张洪 黎黎 《中国卒中杂志》 2014年第2期106-116,共11页
目的系统评价立体定向软通道颅内血肿清除术治疗高血压性脑出血的效果。〈br〉方法计算机检索国内外数据库中关于立体定向软通道颅内血肿清除术与内科保守治疗高血压性脑出血的随机对照试验(randomizedcontroledtrial,RCT),同时追... 目的系统评价立体定向软通道颅内血肿清除术治疗高血压性脑出血的效果。〈br〉方法计算机检索国内外数据库中关于立体定向软通道颅内血肿清除术与内科保守治疗高血压性脑出血的随机对照试验(randomizedcontroledtrial,RCT),同时追索纳入文献的参考文献。检索时限均从建库至2012年12月。根据卫生系统中证据推荐分级的评估、制订与评价(gradingofrecommendationsassessment,developmentandevaluation,GRADE)系统推荐分级方法,对纳入研究的质量进行严格评价和资料提取,对符合质量标准的RCT进行Meta分析。统计学分析采用RevMan5.2软件和GRADEprofiler4.0.3软件。〈br〉结果共纳入11个RCT。Meta分析主要结局结果显示,定向软通道颅内血肿清除术治疗高血压性脑出血3个月内的临床疗效、病死率、发生感染、发生再出血四个方面,与传统的内科保守治疗方法相比,其差异有显著性,优势比(oddsratio,OR)和95%可信区间(confidenceinterval,CI)分别为3.34(2.13~5.22)、0.42(0.29~0.60)、0.42(0.27~0.64)、0.47(0.28~0.77)。每个结局的GRADE系统推荐分级均为低等级。〈br〉结论现有研究显示立体定向软通道颅内血肿清除术治疗高血压性脑出血疗效确切,3个月病死率、发生感染及再出血并发症较传统内科保守治疗更低,临床医师在治疗高血压性脑出血时,可以把立体定向软通道颅内血肿清除术作为一般推荐。 展开更多
关键词 高血压性脑出血 立体定向血肿清除术 疗效 感染 再出血 病死率 META分析
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Psychological Distress, Social Support and Medication Adherence in Patients with Ischemic Stroke in the Mainland of China 被引量:13
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作者 张洪 钱海舟 +6 位作者 孟曙庆 舒敏 高永哲 徐艳 张胜名 红梅 熊荣红 《Journal of Huazhong University of Science and Technology(Medical Sciences)》 SCIE CAS 2015年第3期405-410,共6页
Stroke research and rehabilitation have traditionally focused on the physical and functional impact of a stroke. Less attention has been given to the psychosocial factors associated with this chronic condition. By the... Stroke research and rehabilitation have traditionally focused on the physical and functional impact of a stroke. Less attention has been given to the psychosocial factors associated with this chronic condition. By the few studies that have specifically focused on psychosocial factors in the context of stroke, poststroke depression is demonstrated to significantly influence stroke outcomes. Associations of stroke with psychological symptoms other than depression have rarely been evaluated. This study was aimed to investigate the changes of psychological stress, social support and medication adherence in patients with ischemic stroke in the mainland of China. In this study, 90 patients with hemiplegia one year after first-ever middle cerebral artery infarction(stroke group) in the Zhongnan Hospital of Wuhan University from June 2008 to June 2011 were recruited for interview. Ninety age- and sex-matched normal volunteers(control group) were also examined at the same period. The psychological distress was assessed by the Symptom Checklist 90(SCL-90), the social support by the Social Support Rating Scale(SSRS), and medication adherence by Morisky's self-reported inventory, respectively. Group differences were analyzed using unpaired-t test and chi-squared test. The results showed that total mean scores of the SCL-90 in the stroke group were higher than those in the control group(P〈0.01). Except two dimensions, paranoid ideation and psychoticism, mean scores of the rest dimensions(including somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, and phobic anxiety) of SCL-90 were significantly higher in the stroke group than those in the control group(P〈0.05, or P〈0.01). The objective support, subjective support, support availability and total social support scores in the stroke group were significantly higher than those in the control group(P〈0.05, or P〈0.01). Those in the "SCL-90 total scores 〉150 group" were significantly higher than in the "SCL-90 total scores 〈100 group" and the "SCL-90 total scores between 100 to 150 group"(P〈0.05, or P〈0.01). Those in the "SCL-90 total scores between 100 to 150 group" were significantly higher than in the "SCL-90 total scores 〈100 group"(P〈0.05). In 90 patients with ischemic stroke, 26(28.89%) patients obtained high medication adherence, 47(52.22%) patients medium medication adherence, and 17(18.89%) patients low medication adherence, respectively. Among these stroke patients, there were 17(50.00%) patients with high medication adherence in the "SCL-90 total scores 〉150 group", 28(75.67%) patients with medium medication adherence in the "SCL-90 total scores between 100 to 150 group", and 12(61.16%) patients with low medication adherence in the "SCL-90 total scores 〈100 group", respectively. There was significant difference in the medication adherence rate among the different SCL-90 scores groups in these stroke patients(P〈0.05 or P〈0.01). It was led to conclude that ischemic stroke patients one year after hemiplegia have psychological distress, low level of social support and poor medication adherence in the mainland of China. Therefore, it is necessary to mobilize the government, medical institutions and various social support groups to offer psychological interventions to relieve the stress of patients with ischemic stroke, and improve their medication adherence. 展开更多
关键词 STROKE psychological distress social support medication adherence
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难治性癫痫的治疗进展 被引量:31
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作者 孟曙庆 张洪 《中华临床医师杂志(电子版)》 CAS 2013年第15期142-145,共4页
癫痫是神经系统的常见病,在人群中的发病率为0.6%∽1.1%,其中60%∽70%的患者在服用抗痫药物时仍会发作,导致一部分患者自行停止药物治疗[1]。目前我国约600万以上的癫痫患者,每年新发癫痫患者65万∽70万,大约25%为难治性癫痫。虽然目前... 癫痫是神经系统的常见病,在人群中的发病率为0.6%∽1.1%,其中60%∽70%的患者在服用抗痫药物时仍会发作,导致一部分患者自行停止药物治疗[1]。目前我国约600万以上的癫痫患者,每年新发癫痫患者65万∽70万,大约25%为难治性癫痫。虽然目前癫痫的诊疗取得了很大的进展,但难治性癫痫患者的数量却在日益增多。广义难治性癫痫是指使用目前的抗癫痫药物(AEDs)规范治疗,不能终止其发作或已被临床证实是难治的癫痫及癫痫综合征。 展开更多
关键词 难治性癫痫 药物治疗 癫痫患者 抗癫痫药物 癫痫综合征 神经系统 抗痫药物 规范治疗
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