美育是通过对人审美能力的训练和锻造,培养人发现美、感受美、表现美,特别是理解美和创造美的能力。审美能力本质上就是人的一种认知能力(faculty of cognition),高度地依赖于关于世界的丰富经验与知识。中国古典诗词中所蕴藏的诸多认...美育是通过对人审美能力的训练和锻造,培养人发现美、感受美、表现美,特别是理解美和创造美的能力。审美能力本质上就是人的一种认知能力(faculty of cognition),高度地依赖于关于世界的丰富经验与知识。中国古典诗词中所蕴藏的诸多认识世界的思维法则及古典意象语言,具有独特的艺术价值和教育价值,为扩展我们对世界的认知提供了极有价值的途径。当前,我国古典诗词教育存在过于重视记诵,单独强调作者情感分类,忽视审美意识和审美判断力的培养,忽视对情感与认知关系的理解等问题。基于这种现状,当下古典诗词教育需要有新的调整,即回归诗词文学审美本质,揭示其背后的普遍思维法则,重视古典诗词审美判断中的反思与省察,启迪学生去洞察和把握其中所揭示出来的广袤世界中有价值的新联系,帮助学生去深刻领会诗词作品的不朽审美价值。展开更多
Objective To screen the target genes that are associated with survival of breast cancer(BRCA) and explore their prognostic values and immune correlations with BRCA using multiple databases..Methods The microarray expr...Objective To screen the target genes that are associated with survival of breast cancer(BRCA) and explore their prognostic values and immune correlations with BRCA using multiple databases..Methods The microarray expression datasets of BRCA were downloaded from the Gene Expresssion Omnibus database(GEO) and analyzed to obtain differentially expressed genes(DEGs). Hub genes were obtained by constructing and visualizing the protein-protein interaction network of DEGs. The key gene was determined using R language, STRING, and Cytoscape, and the differential expression of the key gene was verified using external datasets The Cancer Genome Atlas(TCGA) and quantitative real-time PCR(q RT-PCR) for BRCA tissues of 37 patients. The prognostic value and immunological correlation of UBE2C in BRCA were explored using R language, TIMER, and Gene Set Enrichment Analysis(GSEA).Results Of 10 hub genes seleceed from 302 DEGS, UBE2C was identified as the gene associated with BRCA survival. The expression of UBE2C was differentially upregulated in BRCA, as verified by TCGA and q RT-PCR. Prognostic analysis revealed that UBE2C served as an independent prognostic factor. High expression of UBE2C was associated with decreased immune infiltration levels of B cells, CD4+ T cells, CD8+ T cells, macrophages, and myeloid dendritic cells in BRCA tissue. The expression of UBE2C in BRCA showed a significant correlation with immune checkpoints genes PDCD1, CD274, and CTLA4 expressions. There was a positive correlation between the expression of UBE2C and the tumor mutational burden and microsatellite instability. GSEA demonstrated that UBE2C expression significantly enriched 786 immune-related gene sets.Conclusions UBE2C expression in BRCA tissues is closely related to the BRCA immune microenvironment and showes predictive values on the survivals and prognosis of BRCA patients and the effecacy of immunotherapy. UBE2C may be an potential immune-related prognostic biomarker for BRCA.展开更多
非浓缩复原汁(not from concentrate,NFC)果汁产品品质对原料的要求较高。为评价不同品种苹果加工NFC果汁的适应性,以10个苹果品种为原料,对其固酸比、色值、总酚、维生素C、稳定性等12个指标进行测定,并以测定结果为依据,采用层次分析...非浓缩复原汁(not from concentrate,NFC)果汁产品品质对原料的要求较高。为评价不同品种苹果加工NFC果汁的适应性,以10个苹果品种为原料,对其固酸比、色值、总酚、维生素C、稳定性等12个指标进行测定,并以测定结果为依据,采用层次分析法构建模型。结果表明,NFC苹果汁品质评价模型为Y=0.0866×可溶性固形物+0.1841×固酸比+0.2385×总酚+0.0408×L*-0.4500×稳定性,依据此模型计算得出‘富士’苹果的得分最高,这说明‘富士’苹果较适宜加工NFC果汁。采用模糊评价法对构建的模型进行验证,建模得分与模糊评价法得分呈线性相关,因此该模型可用于不同品种苹果加工NFC果汁适应性的判定。展开更多
文摘美育是通过对人审美能力的训练和锻造,培养人发现美、感受美、表现美,特别是理解美和创造美的能力。审美能力本质上就是人的一种认知能力(faculty of cognition),高度地依赖于关于世界的丰富经验与知识。中国古典诗词中所蕴藏的诸多认识世界的思维法则及古典意象语言,具有独特的艺术价值和教育价值,为扩展我们对世界的认知提供了极有价值的途径。当前,我国古典诗词教育存在过于重视记诵,单独强调作者情感分类,忽视审美意识和审美判断力的培养,忽视对情感与认知关系的理解等问题。基于这种现状,当下古典诗词教育需要有新的调整,即回归诗词文学审美本质,揭示其背后的普遍思维法则,重视古典诗词审美判断中的反思与省察,启迪学生去洞察和把握其中所揭示出来的广袤世界中有价值的新联系,帮助学生去深刻领会诗词作品的不朽审美价值。
文摘Objective To screen the target genes that are associated with survival of breast cancer(BRCA) and explore their prognostic values and immune correlations with BRCA using multiple databases..Methods The microarray expression datasets of BRCA were downloaded from the Gene Expresssion Omnibus database(GEO) and analyzed to obtain differentially expressed genes(DEGs). Hub genes were obtained by constructing and visualizing the protein-protein interaction network of DEGs. The key gene was determined using R language, STRING, and Cytoscape, and the differential expression of the key gene was verified using external datasets The Cancer Genome Atlas(TCGA) and quantitative real-time PCR(q RT-PCR) for BRCA tissues of 37 patients. The prognostic value and immunological correlation of UBE2C in BRCA were explored using R language, TIMER, and Gene Set Enrichment Analysis(GSEA).Results Of 10 hub genes seleceed from 302 DEGS, UBE2C was identified as the gene associated with BRCA survival. The expression of UBE2C was differentially upregulated in BRCA, as verified by TCGA and q RT-PCR. Prognostic analysis revealed that UBE2C served as an independent prognostic factor. High expression of UBE2C was associated with decreased immune infiltration levels of B cells, CD4+ T cells, CD8+ T cells, macrophages, and myeloid dendritic cells in BRCA tissue. The expression of UBE2C in BRCA showed a significant correlation with immune checkpoints genes PDCD1, CD274, and CTLA4 expressions. There was a positive correlation between the expression of UBE2C and the tumor mutational burden and microsatellite instability. GSEA demonstrated that UBE2C expression significantly enriched 786 immune-related gene sets.Conclusions UBE2C expression in BRCA tissues is closely related to the BRCA immune microenvironment and showes predictive values on the survivals and prognosis of BRCA patients and the effecacy of immunotherapy. UBE2C may be an potential immune-related prognostic biomarker for BRCA.
文摘非浓缩复原汁(not from concentrate,NFC)果汁产品品质对原料的要求较高。为评价不同品种苹果加工NFC果汁的适应性,以10个苹果品种为原料,对其固酸比、色值、总酚、维生素C、稳定性等12个指标进行测定,并以测定结果为依据,采用层次分析法构建模型。结果表明,NFC苹果汁品质评价模型为Y=0.0866×可溶性固形物+0.1841×固酸比+0.2385×总酚+0.0408×L*-0.4500×稳定性,依据此模型计算得出‘富士’苹果的得分最高,这说明‘富士’苹果较适宜加工NFC果汁。采用模糊评价法对构建的模型进行验证,建模得分与模糊评价法得分呈线性相关,因此该模型可用于不同品种苹果加工NFC果汁适应性的判定。