钠–葡萄糖共转运蛋白2抑制剂(sodium-glucose cotransporter 2 inhibitors, SGLT2i)是一种新型的降糖药物,通过减少近曲小管对葡萄糖的重吸收,增加尿糖排泄来降低血糖。临床研究表明,SGLT2i能显著改善心血管和肾脏结局的临床获益,并具...钠–葡萄糖共转运蛋白2抑制剂(sodium-glucose cotransporter 2 inhibitors, SGLT2i)是一种新型的降糖药物,通过减少近曲小管对葡萄糖的重吸收,增加尿糖排泄来降低血糖。临床研究表明,SGLT2i能显著改善心血管和肾脏结局的临床获益,并具有良好的安全性。促使2型糖尿病的治疗从单一的控制血糖转向改善心血管和肾脏临床预后,从而降低2型糖尿病患者的全因死亡风险。本文从其临床获益证据、作用机制和药物安全性3个方面进行综述。Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel hypoglycemic agents that lower blood glucose by decreasing glucose reabsorption in proximal tubules and increasing urinary glucose excretion. Clinical studies have shown that SGLT2i can significantly improve the clinical benefit of cardiovascular and renal outcomes, and have a favorable safety profile. It has led to a shift in the treatment of type 2 diabetes from single glycemic control to improvement of cardiovascular and renal clinical prognosis, thereby reducing the risk of all-cause mortality in patients with type 2 diabetes mellitus. This article reviews the evidence of clinical benefit, mechanism of action and safety of SGLT2i.展开更多
死亡相关蛋白激酶(death-associated protein kinase,DAPK)基因启动子区域高甲基化可使其表达沉默,从而抑制细胞凋亡,诱导肿瘤的发生和转移。在不同肿瘤类型或关于同一类肿瘤的不同报道中,DAPK基因甲基化数据相差很大。此外,大多数DAPK...死亡相关蛋白激酶(death-associated protein kinase,DAPK)基因启动子区域高甲基化可使其表达沉默,从而抑制细胞凋亡,诱导肿瘤的发生和转移。在不同肿瘤类型或关于同一类肿瘤的不同报道中,DAPK基因甲基化数据相差很大。此外,大多数DAPK基因甲基化研究缺乏相应m RNA或蛋白表达数据。因此,规范DAPK甲基化及表达检测手段,明确其作用机制,对肿瘤中的DAPK研究至关重要。展开更多
文摘钠–葡萄糖共转运蛋白2抑制剂(sodium-glucose cotransporter 2 inhibitors, SGLT2i)是一种新型的降糖药物,通过减少近曲小管对葡萄糖的重吸收,增加尿糖排泄来降低血糖。临床研究表明,SGLT2i能显著改善心血管和肾脏结局的临床获益,并具有良好的安全性。促使2型糖尿病的治疗从单一的控制血糖转向改善心血管和肾脏临床预后,从而降低2型糖尿病患者的全因死亡风险。本文从其临床获益证据、作用机制和药物安全性3个方面进行综述。Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are novel hypoglycemic agents that lower blood glucose by decreasing glucose reabsorption in proximal tubules and increasing urinary glucose excretion. Clinical studies have shown that SGLT2i can significantly improve the clinical benefit of cardiovascular and renal outcomes, and have a favorable safety profile. It has led to a shift in the treatment of type 2 diabetes from single glycemic control to improvement of cardiovascular and renal clinical prognosis, thereby reducing the risk of all-cause mortality in patients with type 2 diabetes mellitus. This article reviews the evidence of clinical benefit, mechanism of action and safety of SGLT2i.
文摘死亡相关蛋白激酶(death-associated protein kinase,DAPK)基因启动子区域高甲基化可使其表达沉默,从而抑制细胞凋亡,诱导肿瘤的发生和转移。在不同肿瘤类型或关于同一类肿瘤的不同报道中,DAPK基因甲基化数据相差很大。此外,大多数DAPK基因甲基化研究缺乏相应m RNA或蛋白表达数据。因此,规范DAPK甲基化及表达检测手段,明确其作用机制,对肿瘤中的DAPK研究至关重要。
