高原心脏损伤(HACI)是由于高原缺氧引起的常见组织损伤之一,严重时可危及生命。研究表明,缺氧诱导因子-1α (HIF-1α)是一种氧敏感转录因子,在缺氧条件下显著增高,介导了机体对缺氧的适应性代谢反应,通过改善线粒体功能,降低细胞氧化应...高原心脏损伤(HACI)是由于高原缺氧引起的常见组织损伤之一,严重时可危及生命。研究表明,缺氧诱导因子-1α (HIF-1α)是一种氧敏感转录因子,在缺氧条件下显著增高,介导了机体对缺氧的适应性代谢反应,通过改善线粒体功能,降低细胞氧化应激反应,激活心肌细胞缺氧信号转导通路和下游基因,在HACI中起关键作用。HIF-1α的相关生物学研究显著提高了对氧稳态的理解,本文就HIF-1α在HACI中的作用及其相关作用机制进行综述,期望为治疗HACI提供部分证据。High altitude cardiac injury (HACI) is one of the common tissue injuries caused by high altitude hypoxia, which can be life-threatening in severe cases. Hypoxia-inducible factor-1α (HIF-1α) has been shown to be an oxygen-sensitive transcription factor that increases markedly in hypoxic conditions, mediates the adaptive metabolic response to hypoxia in the body, and plays a key role in HACI by improving mitochondrial function, decreasing cellular oxidative stress responses, activating cardiomyocyte hypoxic signaling pathways and downstream genes. Relevant biological studies on HIF-1α have significantly improved the understanding of oxygen homeostasis, and this article reviews the role of HIF-1α in HACI and its associated mechanisms of action, with the hope of providing some evidence for the treatment of HACI.展开更多
文摘高原心脏损伤(HACI)是由于高原缺氧引起的常见组织损伤之一,严重时可危及生命。研究表明,缺氧诱导因子-1α (HIF-1α)是一种氧敏感转录因子,在缺氧条件下显著增高,介导了机体对缺氧的适应性代谢反应,通过改善线粒体功能,降低细胞氧化应激反应,激活心肌细胞缺氧信号转导通路和下游基因,在HACI中起关键作用。HIF-1α的相关生物学研究显著提高了对氧稳态的理解,本文就HIF-1α在HACI中的作用及其相关作用机制进行综述,期望为治疗HACI提供部分证据。High altitude cardiac injury (HACI) is one of the common tissue injuries caused by high altitude hypoxia, which can be life-threatening in severe cases. Hypoxia-inducible factor-1α (HIF-1α) has been shown to be an oxygen-sensitive transcription factor that increases markedly in hypoxic conditions, mediates the adaptive metabolic response to hypoxia in the body, and plays a key role in HACI by improving mitochondrial function, decreasing cellular oxidative stress responses, activating cardiomyocyte hypoxic signaling pathways and downstream genes. Relevant biological studies on HIF-1α have significantly improved the understanding of oxygen homeostasis, and this article reviews the role of HIF-1α in HACI and its associated mechanisms of action, with the hope of providing some evidence for the treatment of HACI.
