With the rapid development of information and communication technology,a key objective in the field of optoelectronic integrated devices is to reduce the nano-laser size and energy consumption.Photonics nanolasers are...With the rapid development of information and communication technology,a key objective in the field of optoelectronic integrated devices is to reduce the nano-laser size and energy consumption.Photonics nanolasers are unable to exceed the diffraction limit and typically exhibit low modulation rates of several GHz.In contrast,plasmonic nanolaser utilizes highly confined surface plasmon polariton(SPP)mode that can exceed diffraction limit and their strong Purcell effect can accelerate the modulation rates to several THz.Herein,we propose a parametrically tunable artificial plasmonic nanolasers based on metal–insulator–semiconductor–insulator–metal(MISIM)structure,which demonstrates its ability to compress the mode field volume toλ/14.As the pump power increases,the proposed artificial plasmonic nanolaser exhibits 20-nm-wide output spectrum.Additionally,we investigate the effects of various cavity parameters on the nanolaser’s output threshold,offering potentials for realizing low-threshold artificial plasmonic nanolasers.Moreover,we observe a blue shift in the center wavelength of the nanolaser output with thinner gain layer thickness,predominantly attributed to the increased exciton–photon coupling strength.Our work brings inspiration to several areas,including spaser-based interconnects,nano-LEDs,spontaneous emission control,miniaturization of photon condensates,eigenmode engineering of plasmonic nanolasers,and optimal design driven by artificial intelligence(AI).展开更多
目的运用基于症状(symptoms)、狭窄(stenosis)、斑块(plaque)和颅内代偿(collateral compensation)的颈动脉新型分级体系SSPC的四维度评价方法,评价在颈动脉狭窄患者的预后判断及血运重建获益中的作用。方法回顾性收集2013年1月至2017...目的运用基于症状(symptoms)、狭窄(stenosis)、斑块(plaque)和颅内代偿(collateral compensation)的颈动脉新型分级体系SSPC的四维度评价方法,评价在颈动脉狭窄患者的预后判断及血运重建获益中的作用。方法回顾性收集2013年1月至2017年12月复旦大学附属华山医院和复旦大学附属浦东医院诊断为颈动脉狭窄的945例患者资料。入组患者根据治疗方式分为血运重建组(514例)和最佳药物治疗组(best medical therapy,BMT)组(431例)。比较患者的基线情况、临床和病变特征、SSPC分级和随访5年的预后情况,利用Kaplan-Meier生存曲线分析计算患者免于卒中率。结果血运重建组患者中,10.3%被分类为SSPCⅡ级,41.4%为SSPCⅢ级,45.1%为SSPCⅣ级,而BMT组患者19.7%被分类为SSPCⅡ级,49.2%为SSPCⅢ级,13.2%为SSPCⅣ级。颈动脉SSPCⅢ级患者接受血运重建和BMT的5年卒中发生率分别为2.3%和5.1%,差异有统计学意义(P=0.023)。血运重建组5年免于卒中发生率为(94.1±1.1)%,而BMT组为(89.5±1.6)%,差异有统计学意义(P<0.001)。两组无症状颈动脉狭窄患者在免于卒中发生率方面差异无统计学意义(P=0.091),而在被分类为SSPCⅢ级的无症状患者中,血运重建和BMT之间的5年免于卒中发生率存在显著差异[(96.0±2.0)%比(89.1±2.4)%,P=0.041]。结论颈动脉SSPC分级体系能够通过多维度的颈动脉狭窄卒中风险分层,以提供更合适的治疗策略,丰富颈动脉的治疗指征。展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.12174037,12204061,12204030,and 62375003)the Fundamental Research Funds for the Central Universities,China(Grant No.2022XD-A09)the Fund from the State Key Laboratory of Information Photonics and Optical Communication,China(Grant No.IPOC2021ZZ02)。
文摘With the rapid development of information and communication technology,a key objective in the field of optoelectronic integrated devices is to reduce the nano-laser size and energy consumption.Photonics nanolasers are unable to exceed the diffraction limit and typically exhibit low modulation rates of several GHz.In contrast,plasmonic nanolaser utilizes highly confined surface plasmon polariton(SPP)mode that can exceed diffraction limit and their strong Purcell effect can accelerate the modulation rates to several THz.Herein,we propose a parametrically tunable artificial plasmonic nanolasers based on metal–insulator–semiconductor–insulator–metal(MISIM)structure,which demonstrates its ability to compress the mode field volume toλ/14.As the pump power increases,the proposed artificial plasmonic nanolaser exhibits 20-nm-wide output spectrum.Additionally,we investigate the effects of various cavity parameters on the nanolaser’s output threshold,offering potentials for realizing low-threshold artificial plasmonic nanolasers.Moreover,we observe a blue shift in the center wavelength of the nanolaser output with thinner gain layer thickness,predominantly attributed to the increased exciton–photon coupling strength.Our work brings inspiration to several areas,including spaser-based interconnects,nano-LEDs,spontaneous emission control,miniaturization of photon condensates,eigenmode engineering of plasmonic nanolasers,and optimal design driven by artificial intelligence(AI).
文摘目的运用基于症状(symptoms)、狭窄(stenosis)、斑块(plaque)和颅内代偿(collateral compensation)的颈动脉新型分级体系SSPC的四维度评价方法,评价在颈动脉狭窄患者的预后判断及血运重建获益中的作用。方法回顾性收集2013年1月至2017年12月复旦大学附属华山医院和复旦大学附属浦东医院诊断为颈动脉狭窄的945例患者资料。入组患者根据治疗方式分为血运重建组(514例)和最佳药物治疗组(best medical therapy,BMT)组(431例)。比较患者的基线情况、临床和病变特征、SSPC分级和随访5年的预后情况,利用Kaplan-Meier生存曲线分析计算患者免于卒中率。结果血运重建组患者中,10.3%被分类为SSPCⅡ级,41.4%为SSPCⅢ级,45.1%为SSPCⅣ级,而BMT组患者19.7%被分类为SSPCⅡ级,49.2%为SSPCⅢ级,13.2%为SSPCⅣ级。颈动脉SSPCⅢ级患者接受血运重建和BMT的5年卒中发生率分别为2.3%和5.1%,差异有统计学意义(P=0.023)。血运重建组5年免于卒中发生率为(94.1±1.1)%,而BMT组为(89.5±1.6)%,差异有统计学意义(P<0.001)。两组无症状颈动脉狭窄患者在免于卒中发生率方面差异无统计学意义(P=0.091),而在被分类为SSPCⅢ级的无症状患者中,血运重建和BMT之间的5年免于卒中发生率存在显著差异[(96.0±2.0)%比(89.1±2.4)%,P=0.041]。结论颈动脉SSPC分级体系能够通过多维度的颈动脉狭窄卒中风险分层,以提供更合适的治疗策略,丰富颈动脉的治疗指征。
