Recently, adverse effects of Polygoni Multiflori Radix（PMR） and Polygoni Multiflori Radix Praeparata（PMRP） have attracted intensive attention worldwide. These adverse effects most occurred in cases with high dose ...Recently, adverse effects of Polygoni Multiflori Radix（PMR） and Polygoni Multiflori Radix Praeparata（PMRP） have attracted intensive attention worldwide. These adverse effects most occurred in cases with high dose of prolonged medication course. Liver is usually the target organ of these adverse effects. In the present research, we performed in vivo chronic toxicity study and aimed to evaluate relationships between major constituents of water extractions and total anthraquinone of PMR and PMRP and chronic toxicity. SD rats of both sexes were given water extractions as well as total anthraquinone of PMR and PMRP for 12 weeks. We evaluated basic biochemical indexes, conducted microscopic observations of main organs and assessed early indicators of liver and renal fibrosis. Simvastatin, with hypertriglyceridemia and hypercholesterolemia as its main therapeutic areas, was investigated in our study. Component-toxicity relationships were also discussed. Five male rats died in our study, while all female rats survived, suggesting that some gender differences might be involved. Body weight was significantly changed, and basic biochemical indexes were sporadically occurred during the research. Pathological examinations on liver and kidney showed slight alternations after 12 weeks without dose-dependent relationship. Increase in serum laminin（LN） was observed in almost all male rats, indicating that the risks of liver or kidney fibrosis still existed, especially for males, although no fibrosis was found in the pathological examination of liver and kidney. No major and severe adverse effects were observed after 12 weeks of administration of PMR and PMRP. Regular safety monitoring is still necessary during medication in order to prevent possible risks.展开更多
目的探讨不同涂抹范围的盐酸奥布卡因凝胶对气管插管全麻下治疗学龄前期儿童龋病疗效的影响。方法选取2018年9月-2019年4月的120例龋齿学龄前患儿,随机分成石蜡油1组、石蜡油2组、石蜡油3组、奥布卡因1组、奥布卡因2组和奥布卡因3组,每...目的探讨不同涂抹范围的盐酸奥布卡因凝胶对气管插管全麻下治疗学龄前期儿童龋病疗效的影响。方法选取2018年9月-2019年4月的120例龋齿学龄前患儿,随机分成石蜡油1组、石蜡油2组、石蜡油3组、奥布卡因1组、奥布卡因2组和奥布卡因3组,每组患儿20例。奥布卡因组在气管导管套囊及前端、导管前端1/3及导管前端1/2分别均匀涂抹盐酸奥布卡因凝胶,石蜡油组涂抹方式和范围与奥布卡因组相同。比较各组麻醉诱导前(T0)、麻醉诱导后(T1)、气管插管时(T2)、气管插管后10 min (T3)、气管插管后20 min (T4)、气管拔管时(T5)、气管拔管后10 min (T6)、气管拔管后20 min (T7)平均动脉压(MAP)、心率(HR)变化;应用面部表情分级评分法(FRS)评估各组患儿拔管后1、2 h咽喉疼痛程度;比较各组并发症发生情况。结果 T2~T6时,盐酸奥布卡因各亚组与石蜡油各亚组MAP和HR比较差异均有统计学意义(均P<0.05)。盐酸奥布卡因组内T2~T6的MAP和HR比较差异均有统计学意义(均P<0.05)。石蜡油组内T2~T6的MAP和HR比较差异均有统计学意义(均P<0.05)。术前、术后1 h、术后2 h,各组FRS评分比较差异均有统计学意义(均P<0.05)。各组术后并发症发生率比较差异有统计学意义(P<0.05)。盐酸奥布卡因组内并发症发生率比较差异无统计学意义(P>0.05),石蜡油组内并发症发生率比较差异有统计学意义(P<0.05)。结论在导管套囊及前端整体涂抹盐酸奥布卡因凝胶可以帮助减轻气管插管全麻下治疗龋齿的学龄前期儿童的疼痛反应,患儿围术期血流动力学平稳,并发症较少。展开更多
基金National Natural Science Foundation of China(Grant No.8106033781260553+2 种基金81460623)Natural Science Foundation of Yunnan Province(Grant No.2014FA0352012FD043)
文摘Recently, adverse effects of Polygoni Multiflori Radix（PMR） and Polygoni Multiflori Radix Praeparata（PMRP） have attracted intensive attention worldwide. These adverse effects most occurred in cases with high dose of prolonged medication course. Liver is usually the target organ of these adverse effects. In the present research, we performed in vivo chronic toxicity study and aimed to evaluate relationships between major constituents of water extractions and total anthraquinone of PMR and PMRP and chronic toxicity. SD rats of both sexes were given water extractions as well as total anthraquinone of PMR and PMRP for 12 weeks. We evaluated basic biochemical indexes, conducted microscopic observations of main organs and assessed early indicators of liver and renal fibrosis. Simvastatin, with hypertriglyceridemia and hypercholesterolemia as its main therapeutic areas, was investigated in our study. Component-toxicity relationships were also discussed. Five male rats died in our study, while all female rats survived, suggesting that some gender differences might be involved. Body weight was significantly changed, and basic biochemical indexes were sporadically occurred during the research. Pathological examinations on liver and kidney showed slight alternations after 12 weeks without dose-dependent relationship. Increase in serum laminin（LN） was observed in almost all male rats, indicating that the risks of liver or kidney fibrosis still existed, especially for males, although no fibrosis was found in the pathological examination of liver and kidney. No major and severe adverse effects were observed after 12 weeks of administration of PMR and PMRP. Regular safety monitoring is still necessary during medication in order to prevent possible risks.
文摘目的探讨不同涂抹范围的盐酸奥布卡因凝胶对气管插管全麻下治疗学龄前期儿童龋病疗效的影响。方法选取2018年9月-2019年4月的120例龋齿学龄前患儿,随机分成石蜡油1组、石蜡油2组、石蜡油3组、奥布卡因1组、奥布卡因2组和奥布卡因3组,每组患儿20例。奥布卡因组在气管导管套囊及前端、导管前端1/3及导管前端1/2分别均匀涂抹盐酸奥布卡因凝胶,石蜡油组涂抹方式和范围与奥布卡因组相同。比较各组麻醉诱导前(T0)、麻醉诱导后(T1)、气管插管时(T2)、气管插管后10 min (T3)、气管插管后20 min (T4)、气管拔管时(T5)、气管拔管后10 min (T6)、气管拔管后20 min (T7)平均动脉压(MAP)、心率(HR)变化;应用面部表情分级评分法(FRS)评估各组患儿拔管后1、2 h咽喉疼痛程度;比较各组并发症发生情况。结果 T2~T6时,盐酸奥布卡因各亚组与石蜡油各亚组MAP和HR比较差异均有统计学意义(均P<0.05)。盐酸奥布卡因组内T2~T6的MAP和HR比较差异均有统计学意义(均P<0.05)。石蜡油组内T2~T6的MAP和HR比较差异均有统计学意义(均P<0.05)。术前、术后1 h、术后2 h,各组FRS评分比较差异均有统计学意义(均P<0.05)。各组术后并发症发生率比较差异有统计学意义(P<0.05)。盐酸奥布卡因组内并发症发生率比较差异无统计学意义(P>0.05),石蜡油组内并发症发生率比较差异有统计学意义(P<0.05)。结论在导管套囊及前端整体涂抹盐酸奥布卡因凝胶可以帮助减轻气管插管全麻下治疗龋齿的学龄前期儿童的疼痛反应,患儿围术期血流动力学平稳,并发症较少。
