发育性髋关节发育不良(development dysplasia of the hip, DDH),是儿童骨科常见的肌肉骨骼畸形之一,其发病的确切病因尚不明确,但是遗传因素和环境因素被认为在发病机制中起作用。其发病率存在地区差异和年龄差异,疾病的严重程度以及...发育性髋关节发育不良(development dysplasia of the hip, DDH),是儿童骨科常见的肌肉骨骼畸形之一,其发病的确切病因尚不明确,但是遗传因素和环境因素被认为在发病机制中起作用。其发病率存在地区差异和年龄差异,疾病的严重程度以及治疗方式的选择通过影像学分型来决定,如果没有合适的治疗,DDH儿童将影响正常行走功能以及过早产生骨关节炎,从而对生活质量产生重大影响。如今Pemberton截骨术治疗DDH被儿童骨科医生广泛采用,Pemberton截骨术不仅是一种实现髋臼形态矫正的技术,而且是可以联合其他术式以减少并发症的技术。本综述旨在总结Pemberton截骨术在DDH手术治疗中的应用及相关困难之处,以期为今后更加细节化的治疗提供参考。Developmental dysplasia of the hip (DDH) is one of the common musculoskeletal deformities in pediatric orthopedics. The exact cause of its onset is not yet clear, but genetic and environmental factors are believed to play a role in the pathogenesis. There are regional differences and age differences in its incidence rate. The severity of the disease and the choice of treatment methods are determined by the type of imaging classification. Without proper treatment, DDH children will affect their normal walking function and develop osteoarthritis prematurely, which will have a significant impact on the quality of life. Nowadays, Pemberton osteotomy is widely used by pediatric orthopedic surgeons to treat DDH. Pemberton osteotomy is not only a technique for correcting acetabular morphology, but also a technique that can be combined with other surgical procedures to reduce complications. This review aims to summarize the application and related difficulties of Pemberton osteotomy in the treatment of DDH surgery, in order to provide reference for more detailed treatment in the future.展开更多
发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一...发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一个重要病理变化是关节软骨的退化及退变,但目前关于DDH软骨退变的机制尚未明确。一些研究发现软骨细胞的自噬与骨关节炎密切相关,其中PI3K/AKT信号通路可以促进软骨细胞增殖,并且抑制软骨细胞自噬。本文旨在探讨PI3K/AKT信号通路对软骨细胞自噬的调控作用,为DDH后期的诊疗提供新的思路。展开更多
髋关节发育不良(Developmental Dysplasia of the Hip, DDH)是一种复杂的髋关节疾病,其涉及范围从新生儿的不稳定髋到髋臼或股骨的发育不良、髋关节半脱位直至完全脱位。这种疾病可能导致结构上的改变,从而引发早期的髋关节病变。尽管...髋关节发育不良(Developmental Dysplasia of the Hip, DDH)是一种复杂的髋关节疾病,其涉及范围从新生儿的不稳定髋到髋臼或股骨的发育不良、髋关节半脱位直至完全脱位。这种疾病可能导致结构上的改变,从而引发早期的髋关节病变。尽管已经确定了一些危险因素,但其确切的病因和病理生理机制仍未完全明了。新生儿筛查、体格检查以及超声检查在DDH的早期诊断和预防早期髋关节病变中起到了至关重要的作用。这篇综述着重总结了目前DDH的检测和治疗的实践策略。Developmental Dysplasia of the Hip (DDH) is a complex disease of the Hip, which involves from the unstable Hip to acetabular or femoral Dysplasia, subluxation and complete dislocation of the Hip. The disease can lead to structural changes that can lead to early hip disease. Although a number of risk factors have been identified, the exact etiology and pathophysiological mechanisms remain unclear. Neonatal screening, physical examination and ultrasonography play an important role in the early diagnosis and prevention of DDH. This review summarizes current practical strategies for the detection and treatment of DDH.展开更多
文摘发育性髋关节发育不良(development dysplasia of the hip, DDH),是儿童骨科常见的肌肉骨骼畸形之一,其发病的确切病因尚不明确,但是遗传因素和环境因素被认为在发病机制中起作用。其发病率存在地区差异和年龄差异,疾病的严重程度以及治疗方式的选择通过影像学分型来决定,如果没有合适的治疗,DDH儿童将影响正常行走功能以及过早产生骨关节炎,从而对生活质量产生重大影响。如今Pemberton截骨术治疗DDH被儿童骨科医生广泛采用,Pemberton截骨术不仅是一种实现髋臼形态矫正的技术,而且是可以联合其他术式以减少并发症的技术。本综述旨在总结Pemberton截骨术在DDH手术治疗中的应用及相关困难之处,以期为今后更加细节化的治疗提供参考。Developmental dysplasia of the hip (DDH) is one of the common musculoskeletal deformities in pediatric orthopedics. The exact cause of its onset is not yet clear, but genetic and environmental factors are believed to play a role in the pathogenesis. There are regional differences and age differences in its incidence rate. The severity of the disease and the choice of treatment methods are determined by the type of imaging classification. Without proper treatment, DDH children will affect their normal walking function and develop osteoarthritis prematurely, which will have a significant impact on the quality of life. Nowadays, Pemberton osteotomy is widely used by pediatric orthopedic surgeons to treat DDH. Pemberton osteotomy is not only a technique for correcting acetabular morphology, but also a technique that can be combined with other surgical procedures to reduce complications. This review aims to summarize the application and related difficulties of Pemberton osteotomy in the treatment of DDH surgery, in order to provide reference for more detailed treatment in the future.
文摘发育性髋关节脱位(development dislocation of the hip, DDH),是在髋关节发育不良的基础上,伴有或不伴有股骨头脱位或半脱位于髋臼之外的下肢畸形。其病理改变不同可能会导致严重程度不一的早期骨关节炎(osteoarthritis, OA)。DDH的一个重要病理变化是关节软骨的退化及退变,但目前关于DDH软骨退变的机制尚未明确。一些研究发现软骨细胞的自噬与骨关节炎密切相关,其中PI3K/AKT信号通路可以促进软骨细胞增殖,并且抑制软骨细胞自噬。本文旨在探讨PI3K/AKT信号通路对软骨细胞自噬的调控作用,为DDH后期的诊疗提供新的思路。
文摘髋关节发育不良(Developmental Dysplasia of the Hip, DDH)是一种复杂的髋关节疾病,其涉及范围从新生儿的不稳定髋到髋臼或股骨的发育不良、髋关节半脱位直至完全脱位。这种疾病可能导致结构上的改变,从而引发早期的髋关节病变。尽管已经确定了一些危险因素,但其确切的病因和病理生理机制仍未完全明了。新生儿筛查、体格检查以及超声检查在DDH的早期诊断和预防早期髋关节病变中起到了至关重要的作用。这篇综述着重总结了目前DDH的检测和治疗的实践策略。Developmental Dysplasia of the Hip (DDH) is a complex disease of the Hip, which involves from the unstable Hip to acetabular or femoral Dysplasia, subluxation and complete dislocation of the Hip. The disease can lead to structural changes that can lead to early hip disease. Although a number of risk factors have been identified, the exact etiology and pathophysiological mechanisms remain unclear. Neonatal screening, physical examination and ultrasonography play an important role in the early diagnosis and prevention of DDH. This review summarizes current practical strategies for the detection and treatment of DDH.
