不宁腿综合征（restless leg syndrome,RLS）是一组与睡眠相关、以下肢无法抗拒的运动为特征的感觉运动障碍性疾病,症状常在安静状态下尤其是夜间发作或加重[1]。RLS分为原发性和继发性两类,原发性可能与其遗传特性有关。有研究显示,50...不宁腿综合征（restless leg syndrome,RLS）是一组与睡眠相关、以下肢无法抗拒的运动为特征的感觉运动障碍性疾病,症状常在安静状态下尤其是夜间发作或加重[1]。RLS分为原发性和继发性两类,原发性可能与其遗传特性有关。有研究显示,50%的原发性RLS患者有阳性家族史;继发性RLS则病因相对复杂,展开更多
目的评估帕金森病(Parkinson’s disease,PD)合并不宁腿综合征(Restless legs syndrome,RLS)患者(PD-RLS)与特发性不宁腿综合征(idiopathic restless legs syndrome,iRLS)之间的临床及睡眠特征差异及相关的影响因素。方法收集2015年-202...目的评估帕金森病(Parkinson’s disease,PD)合并不宁腿综合征(Restless legs syndrome,RLS)患者(PD-RLS)与特发性不宁腿综合征(idiopathic restless legs syndrome,iRLS)之间的临床及睡眠特征差异及相关的影响因素。方法收集2015年-2020年收治的125例PD患者以及137例iRLS患者,并根据PD患者是否合并RLS分为PD伴RLS组(PD-RLS)和单纯PD(PD-NRLS)组,比较分析3组的一般状况、临床特征及主客观睡眠检查等的差异。结果PD患者共病RLS的患病率为27.2%。PD-RLS患者UPDRS-Ⅲ评分高于PD-NRLS。PD-RLS患者客观睡眠质量较iRLS患者更差,年龄和共病PD是RLS患者客观睡眠质量差的危险因素。IRLS-RS和HAMD评分是RLS患者主观睡眠质量差的危险因素。结论PD-RLS患者较iRLS患者更易出现客观睡眠障碍,而iRLS患者主观睡眠障碍更重,可能与RLS是否合并PD的临床异质性相关。展开更多
不宁腿综合征(Restless legs syndrome,RLS)又称为Ekbom综合征,是一种感觉运动障碍,其特征是患者主诉强烈的、几乎不可抗拒的肢体运动冲动。这种强烈的冲动通常伴随肢体深处不舒适或难以描述的感觉,但不总是如此。其在休息或静止时加重...不宁腿综合征(Restless legs syndrome,RLS)又称为Ekbom综合征,是一种感觉运动障碍,其特征是患者主诉强烈的、几乎不可抗拒的肢体运动冲动。这种强烈的冲动通常伴随肢体深处不舒适或难以描述的感觉,但不总是如此。其在休息或静止时加重,运动后部分或全部缓解,夜晚症状重于其他时间。展开更多
BACKGROUND:A regimen of epirubicin,cisplatin,and infused fluorouracil(ECF) improves survival among patients with incurable locally advanced or metastatic gastric adenocarcinoma.We assessed whether the addition of a pe...BACKGROUND:A regimen of epirubicin,cisplatin,and infused fluorouracil(ECF) improves survival among patients with incurable locally advanced or metastatic gastric adenocarcinoma.We assessed whether the addition of a perioperative regimen of ECF to surgery improves outcomes among patients with potentially curable gastric cancer.METHODS:We randomly assigned patients with resectable adenocarcinoma of the stomach,esophagogastric junction,or lower esophagus to either perioperative chemotherapy and surgery(250 patients) or surgery alone(253 patients) .Chemotherapy consisted of three preoperative and three postoperative cycles of intravenous epirubicin(50 mg per square meter of body-surface area) and cisplatin(60 mg per square meter) on day 1,and a continuous intravenous infusion of fluorouracil(200 mg per square meter per day) for 21 days.The primary end point was overall survival.RESULTS:ECF-related adverse effects were similar to those previously reported among patients with advanced gastric cancer.Rates of postoperative complications were similar in the perioperative-chemotherapy group and the surgery group(46 percent and 45 percent,respectively) ,as were the numbers of deaths within 30 days after surgery.The resected tumors were significantly smaller and less advanced in the perioperative-chemotherapy group.With a median follow-up of four years,149 patients in the perioperative-chemotherapy group and 170 in the surgery group had died.As compared with the surgery group,the perioperative-chemotherapy group had a higher likelihood of overall survival(hazard ratio for death,0.75;95 percent confidence interval,0.60 to 0.93;P = 0.009;five-year survival rate,36 percent vs.23 percent) and of progression-free survival(hazard ratio for progression,0.66;95 percent confidence interval,0.53 to 0.81;P < 0.001) .CONCLUSIONS:In patients with operable gastric or lower esophageal adenocarcinomas,a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.展开更多
文摘不宁腿综合征（restless leg syndrome,RLS）是一组与睡眠相关、以下肢无法抗拒的运动为特征的感觉运动障碍性疾病,症状常在安静状态下尤其是夜间发作或加重[1]。RLS分为原发性和继发性两类,原发性可能与其遗传特性有关。有研究显示,50%的原发性RLS患者有阳性家族史;继发性RLS则病因相对复杂,
文摘目的评估帕金森病(Parkinson’s disease,PD)合并不宁腿综合征(Restless legs syndrome,RLS)患者(PD-RLS)与特发性不宁腿综合征(idiopathic restless legs syndrome,iRLS)之间的临床及睡眠特征差异及相关的影响因素。方法收集2015年-2020年收治的125例PD患者以及137例iRLS患者,并根据PD患者是否合并RLS分为PD伴RLS组(PD-RLS)和单纯PD(PD-NRLS)组,比较分析3组的一般状况、临床特征及主客观睡眠检查等的差异。结果PD患者共病RLS的患病率为27.2%。PD-RLS患者UPDRS-Ⅲ评分高于PD-NRLS。PD-RLS患者客观睡眠质量较iRLS患者更差,年龄和共病PD是RLS患者客观睡眠质量差的危险因素。IRLS-RS和HAMD评分是RLS患者主观睡眠质量差的危险因素。结论PD-RLS患者较iRLS患者更易出现客观睡眠障碍,而iRLS患者主观睡眠障碍更重,可能与RLS是否合并PD的临床异质性相关。
文摘不宁腿综合征(Restless legs syndrome,RLS)又称为Ekbom综合征,是一种感觉运动障碍,其特征是患者主诉强烈的、几乎不可抗拒的肢体运动冲动。这种强烈的冲动通常伴随肢体深处不舒适或难以描述的感觉,但不总是如此。其在休息或静止时加重,运动后部分或全部缓解,夜晚症状重于其他时间。
文摘BACKGROUND:A regimen of epirubicin,cisplatin,and infused fluorouracil(ECF) improves survival among patients with incurable locally advanced or metastatic gastric adenocarcinoma.We assessed whether the addition of a perioperative regimen of ECF to surgery improves outcomes among patients with potentially curable gastric cancer.METHODS:We randomly assigned patients with resectable adenocarcinoma of the stomach,esophagogastric junction,or lower esophagus to either perioperative chemotherapy and surgery(250 patients) or surgery alone(253 patients) .Chemotherapy consisted of three preoperative and three postoperative cycles of intravenous epirubicin(50 mg per square meter of body-surface area) and cisplatin(60 mg per square meter) on day 1,and a continuous intravenous infusion of fluorouracil(200 mg per square meter per day) for 21 days.The primary end point was overall survival.RESULTS:ECF-related adverse effects were similar to those previously reported among patients with advanced gastric cancer.Rates of postoperative complications were similar in the perioperative-chemotherapy group and the surgery group(46 percent and 45 percent,respectively) ,as were the numbers of deaths within 30 days after surgery.The resected tumors were significantly smaller and less advanced in the perioperative-chemotherapy group.With a median follow-up of four years,149 patients in the perioperative-chemotherapy group and 170 in the surgery group had died.As compared with the surgery group,the perioperative-chemotherapy group had a higher likelihood of overall survival(hazard ratio for death,0.75;95 percent confidence interval,0.60 to 0.93;P = 0.009;five-year survival rate,36 percent vs.23 percent) and of progression-free survival(hazard ratio for progression,0.66;95 percent confidence interval,0.53 to 0.81;P < 0.001) .CONCLUSIONS:In patients with operable gastric or lower esophageal adenocarcinomas,a perioperative regimen of ECF decreased tumor size and stage and significantly improved progression-free and overall survival.
