病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症...病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症。在病毒性脑炎中,上述指标均可能发生变化。现本文对上述指标与重症病毒性脑炎的相关性做简要综述,以期为重症病毒性脑炎早期识别提供更多依据。Viral encephalitis, as one of the major diseases affecting global public health, is a serious central nervous system infection. The increase in white blood cell count is usually associated with infection and inflammation. PCT is a protein that increases in concentration in the plasma during infection, IL-6 plays an important role in acute inflammation, and S100 protein often represents nerve damage and inflammation. In viral encephalitis, the above indicators may undergo changes. This article provides a brief review of the correlation between the above indicators and severe viral encephalitis, in order to provide more evidence for early identification of severe viral encephalitis.展开更多
脑卒中是全球导致残疾和死亡的主要原因,缺血性卒中占主导地位。血清学指标因其简单易得的特点,成为辅助评估的重要工具。炎症指标、血脂代谢指标、肾功能指标以及糖代谢指标在预测卒中严重程度、神经功能恶化风险和预后方面展现出显著...脑卒中是全球导致残疾和死亡的主要原因,缺血性卒中占主导地位。血清学指标因其简单易得的特点,成为辅助评估的重要工具。炎症指标、血脂代谢指标、肾功能指标以及糖代谢指标在预测卒中严重程度、神经功能恶化风险和预后方面展现出显著价值。因此,本文就近年来关于不同血清学指标与脑卒中后神经功能恢复、患者转归及生存率之间关系的研究进展做一综述,以期为未来的临床研究和个体化治疗策略的制定提供参考依据。Stroke is the leading cause of disability and death worldwide, with ischaemic stroke predominating. Serological indices are important tools to aid in assessment because of their simplicity and accessibility. Inflammatory markers, lipid metabolism markers, renal function markers, and glucose metabolism markers have demonstrated significant value in predicting stroke severity, risk of neurological deterioration, and prognosis. Therefore, this article presents a review of recent studies on the relationship between different serological markers and neurological recovery, patient regression and survival after stroke, with the aim of providing a reference basis for future clinical research and the development of individualised therapeutic strategies.展开更多
文摘目的 基于c-Jun氨基末端激酶(JNK)-p62/螯合体(SQSTM1)信号通路探讨糖肾煎对2型糖尿病肾病(DN)大鼠足细胞的保护作用。方法 SD大鼠随机分成正常组、DN组、糖肾煎低、中、高[生药5、10、20 g/(kg·d)]剂量组(糖肾煎-L、M、H组)、二甲双胍组[100 mg/(kg·d)]。除正常组外,其余各组通过喂养高脂高糖饲料和腹腔注射链脲佐菌素(STZ)进行DN模型构建。药物干预结束后,检测大鼠血生化指标空腹血糖(FBG)、负荷后2 h血糖(P2 h BG)、血肌酐(SCr)、血尿素氮(BUN)水平;苏木素-伊红(HE)、六胺银(PASM)染色观察肾组织病理学变化;透射电镜(TEM)观察肾小球基底膜损伤和足细胞变化情况;Western印迹检测肾组织中微管相关蛋白1A/1B-轻链(LC)3、p-JNK、JNK、p62/SQSTM1、肾病蛋白(Nephrin)蛋白表达。结果 与正常组比较,DN组FBG、P2 h BG、SCr、BUN水平及p62/SQSTM1蛋白表达明显升高,LC3-Ⅱ、Nephrin蛋白表达和p-JNK/JNK明显降低(P<0.05);光镜下观察到肾小球缩小、管丛系膜明显扩张,并有基底膜增生增厚等现象;TEM下观察到肾小球基底膜增厚、足细胞排列紊乱、形态改变、足突融合等现象。与DN组比较,糖肾煎-L、M、H组和二甲双胍组FBG、P2 h BG、SCr、BUN水平及p62/SQSTM1蛋白表达明显降低,LC3-Ⅱ、Nephrin蛋白表达和p-JNK/JNK明显升高(P<0.05);并且肾小球基底膜增厚、足细胞足突融合等情况均获得一定程度减轻。结论 糖肾煎对2型DN大鼠足细胞具有一定保护作用,可能是通过调控JNK-p62/SQSTM1信号通路,提高足细胞自噬,从而起到肾脏保护功效。
文摘病毒性脑炎作为影响世界公共卫生的主要疾病之一,是一种严重的中枢神经系统感染。白细胞计数的升高通常与感染和炎症相关,PCT是一种在感染时血浆中浓度升高的蛋白质,IL-6在急性炎症中起着重要作用,S100蛋白则往往代表了神经损伤和炎症。在病毒性脑炎中,上述指标均可能发生变化。现本文对上述指标与重症病毒性脑炎的相关性做简要综述,以期为重症病毒性脑炎早期识别提供更多依据。Viral encephalitis, as one of the major diseases affecting global public health, is a serious central nervous system infection. The increase in white blood cell count is usually associated with infection and inflammation. PCT is a protein that increases in concentration in the plasma during infection, IL-6 plays an important role in acute inflammation, and S100 protein often represents nerve damage and inflammation. In viral encephalitis, the above indicators may undergo changes. This article provides a brief review of the correlation between the above indicators and severe viral encephalitis, in order to provide more evidence for early identification of severe viral encephalitis.
文摘脑卒中是全球导致残疾和死亡的主要原因,缺血性卒中占主导地位。血清学指标因其简单易得的特点,成为辅助评估的重要工具。炎症指标、血脂代谢指标、肾功能指标以及糖代谢指标在预测卒中严重程度、神经功能恶化风险和预后方面展现出显著价值。因此,本文就近年来关于不同血清学指标与脑卒中后神经功能恢复、患者转归及生存率之间关系的研究进展做一综述,以期为未来的临床研究和个体化治疗策略的制定提供参考依据。Stroke is the leading cause of disability and death worldwide, with ischaemic stroke predominating. Serological indices are important tools to aid in assessment because of their simplicity and accessibility. Inflammatory markers, lipid metabolism markers, renal function markers, and glucose metabolism markers have demonstrated significant value in predicting stroke severity, risk of neurological deterioration, and prognosis. Therefore, this article presents a review of recent studies on the relationship between different serological markers and neurological recovery, patient regression and survival after stroke, with the aim of providing a reference basis for future clinical research and the development of individualised therapeutic strategies.
