为解决有机化学课程教学过程中遇到的实际问题,探索因材施教的个性化培养模式,引导学生不断提升学习的主动性和解决实际问题的能力,我们基于OBE(Outcome based education)教育理念,结合中国科学技术大学有机化学课程目标和学习效果金字...为解决有机化学课程教学过程中遇到的实际问题,探索因材施教的个性化培养模式,引导学生不断提升学习的主动性和解决实际问题的能力,我们基于OBE(Outcome based education)教育理念,结合中国科学技术大学有机化学课程目标和学习效果金字塔,以学生学为中心,以成果为导向,精心设计了引导式预习、精准式授课、互助式讨论、示范式点评和全程式考核的线上线下混合“五式”教学法,在实际教学运用中取得了良好成效,达到了预期目标。展开更多
A rapid and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated to quantify levonorgestrel in human plasma.After liquid-liquid extraction with ethyl acetate,the analytes were se...A rapid and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated to quantify levonorgestrel in human plasma.After liquid-liquid extraction with ethyl acetate,the analytes were separated on a Phenomenex Luna C18 column interfaced with a tripe-quadrupole tandem mass spectrometer using positive electrospray ionization.Norethindrone was used as the internal standard.The standard calibration curve was linear over the concentration range 0.625-40 ng·mL-1.The intra-day and inter-day precisions were less than 8.16% from the determination of QC samples.Accuracy was within ±7.3%.The method was successfully applied for pharmacokinetic study of levonorgestrel after oral administration of 1.5 mg levonorgestrel to 20 healthy volunteers.展开更多
文摘为解决有机化学课程教学过程中遇到的实际问题,探索因材施教的个性化培养模式,引导学生不断提升学习的主动性和解决实际问题的能力,我们基于OBE(Outcome based education)教育理念,结合中国科学技术大学有机化学课程目标和学习效果金字塔,以学生学为中心,以成果为导向,精心设计了引导式预习、精准式授课、互助式讨论、示范式点评和全程式考核的线上线下混合“五式”教学法,在实际教学运用中取得了良好成效,达到了预期目标。
文摘A rapid and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated to quantify levonorgestrel in human plasma.After liquid-liquid extraction with ethyl acetate,the analytes were separated on a Phenomenex Luna C18 column interfaced with a tripe-quadrupole tandem mass spectrometer using positive electrospray ionization.Norethindrone was used as the internal standard.The standard calibration curve was linear over the concentration range 0.625-40 ng·mL-1.The intra-day and inter-day precisions were less than 8.16% from the determination of QC samples.Accuracy was within ±7.3%.The method was successfully applied for pharmacokinetic study of levonorgestrel after oral administration of 1.5 mg levonorgestrel to 20 healthy volunteers.
