Biodegradable α-hydroxyl polyesters,such as poly(lactic acid)(PLA)and poly(lactic-co-glycolic acid)(PLGA)were investigated as scaffolds for tissue engineering.However,polymeric materials on the basis of lactide are l...Biodegradable α-hydroxyl polyesters,such as poly(lactic acid)(PLA)and poly(lactic-co-glycolic acid)(PLGA)were investigated as scaffolds for tissue engineering.However,polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells.In this study,the functional polylactide with pendant carboxyl(PLMACA)was synthesized,which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA.The structure and composition of PLMACA were confirmed via {}1H NMR spectrum and the compatibilities for blood and cell were stu-{died.} The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.展开更多
4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and i...4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and it was dehydrated to bromosuccinic anhydride by TFFA. Then the anhydride was alcoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromolecular cyclization of the mixture ester, and then it was further purified by silicon gel chromatogram. The product and the intermediates were characterized by {{}+1H NMR}, {}+{13}C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.展开更多
文摘Biodegradable α-hydroxyl polyesters,such as poly(lactic acid)(PLA)and poly(lactic-co-glycolic acid)(PLGA)were investigated as scaffolds for tissue engineering.However,polymeric materials on the basis of lactide are limited in blood vessel engineering due to their poor hydrophilicity and low affinity for the cells.In this study,the functional polylactide with pendant carboxyl(PLMACA)was synthesized,which was expected to improve the blood compatibility and cell adhesion of polyester based on PLA.The structure and composition of PLMACA were confirmed via {}1H NMR spectrum and the compatibilities for blood and cell were stu-{died.} The results show that the PLMACA is hopeful to be used as blood vessel substitute with good HUVEC adhesion and anti-platelet adhesion.
文摘4-(2-Benzyloxyethoxycarbonyl)-2-oxetanone, an β-substituted-β-lactones with latent pendent hydroxyl groups,was synthesized from L-aspartic acid. Firstly, bromosuccinic acid was synthesized from L-aspartic acid and it was dehydrated to bromosuccinic anhydride by TFFA. Then the anhydride was alcoholysized to the monoester mixture by 2-benzyloxy ethanol. Finally, the novel monomer was got through a intromolecular cyclization of the mixture ester, and then it was further purified by silicon gel chromatogram. The product and the intermediates were characterized by {{}+1H NMR}, {}+{13}C NMR and elemental analysis. In addition, 2-benzyloxy ethanol was synthesized with a simplyified procedure and high yield by using Williamson method.
