慢性肾功能衰竭(chronicrenalfailure, CRF)是慢性肾脏病或其他各种累积并发于肾脏的系统性疾病不断进展的共同结果,症状复杂,病情繁多,患者日常生活标准急剧降低,对人类健康不断造成严重影响。无论是传统医学或现代研究,肾茶在治疗慢...慢性肾功能衰竭(chronicrenalfailure, CRF)是慢性肾脏病或其他各种累积并发于肾脏的系统性疾病不断进展的共同结果,症状复杂,病情繁多,患者日常生活标准急剧降低,对人类健康不断造成严重影响。无论是传统医学或现代研究,肾茶在治疗慢性肾衰竭方面一直成为焦点。临证治疗慢性肾衰竭时,常以肾茶为切入点,本文通过查阅文献主要从药物功能,药理作用,多方面应用(中药结肠灌肠、中药离子导入、中成药、纳米中药等),名家经验等方面对肾茶治疗慢性肾衰竭的研究概况进行简要归纳。Chronic renal failure (CRF) is the common result of the continuous progress of chronic kidney disease or other various cumulative systemic diseases complicated with the kidney. The symptoms are complex, the conditions are various, and the patients’ daily living standards are sharply reduced, which has a serious impact on human health. Whether traditional medicine or modern research, Clerodendranthus spicatus has always been the focus in the treatment of chronic renal failure. In clinical treatment of chronic renal failure, Clerodendranthus spicatus is often taken as the starting point. This article briefly summarizes the research situation of Clerodendranthus spicatus in treating chronic renal failure from the aspects of drug function, pharmacological effect, multiple applications (colon enema of traditional Chinese medicine, iontophoresis of traditional Chinese medicine, Chinese patent medicine, nano Chinese medicine, etc.), and famous experts’ experience.展开更多
目的:基于咽–肠–肾轴理论探讨清咽健脾方加减治疗IgA肾病的效果。方法:IgA肾病是临床比较常见的一种原发性肾小球疾病,其主要症状为血尿,伴有不同程度的蛋白尿,高血压、肾病综合征等肾损害。电镜下表现为肾小球体积系膜区免疫复合物Ig...目的:基于咽–肠–肾轴理论探讨清咽健脾方加减治疗IgA肾病的效果。方法:IgA肾病是临床比较常见的一种原发性肾小球疾病,其主要症状为血尿,伴有不同程度的蛋白尿,高血压、肾病综合征等肾损害。电镜下表现为肾小球体积系膜区免疫复合物IgA的大量沉淀,或以IgA沉淀为主兼见补体C3等沉积。将从中西医两方面角度探讨咽–肠–肾轴理论的可行性及相关治疗方案异同,传统中医学认为,IgA发病责之于肺、脾、肾;西医目前相关主要理论有两点:一是肠肾轴理论,肠道菌群免疫功能在IgA肾病的发生及治疗中起重要作用,二是咽肾密切相关,咽喉为其纽带。本文通过对IgA肾病肠咽肾轴病机的阐释,相关病因阐述以及中西医对于本病的观点及当前治疗方案,并结合本汤药药物作用机制研究,从而进一步探讨清咽健脾方治疗IgA肾病的可行性。结论:基于咽–肠–肾轴理论探讨清咽健脾方治疗IgA肾病的效果良好,能够降低患者24 h尿蛋白定量及尿红细胞计数,有助于改善肾脏功能,延缓肾脏纤维化进展,值得临床采纳。Objective: To investigate the effect of Qingyan Jianpi decoction on IgA nephropathy based on the theory of pharyngoenteric-instine kidney axis. Methods: IgA nephropathy is a common primary glomerular disease. The main symptoms of IGA nephropathy are hematuria, proteinuria, hypertension, nephrotic syndrome and other renal damage. Under electron microscope, the immunocomplex IgA was deposited in the mesangial area of the glomerular volume, or IgA deposition was mainly accompanied by complement C3 deposition. The feasibility of the pharyngoentero-renal axis theory and the similarities and differences of related treatment schemes will be discussed from the perspectives of traditional Chinese and Western medicine. Traditional Chinese medicine believes that the pathogenesis of IgA is the lung, spleen and kidney. At present, there are two main theories related to Western medicine: Firstly, the enterorenal axis theory which means the immune function of intestinal flora plays an important role in the occurrence and development of IgA nephropathy;secondly, the kidney and throat are connected closely, and the throat is its link. In this paper, through the explanation of the pathogenesis of enteropharyngorenal axis of IgA nephropathy, together with the related etiology, and the views of traditional Chinese and western medicine on this disease and the current treatment plan, we combine these with the study of the mechanism of action of this decoction, to further explore the feasibility of Qingyan Jianpi prescription for the treatment of IgA nephropathy. Conclusion: Based on the theory of pharyng-instine-kidney axis, Qingyan Jianpi formula has a significant effect on IgA nephropathy, which can reduce 24 h urinary protein quantity and urinary red blood cell count, and help to improve renal fibrosis, which is worthy of clinical adoption.展开更多
文摘慢性肾功能衰竭(chronicrenalfailure, CRF)是慢性肾脏病或其他各种累积并发于肾脏的系统性疾病不断进展的共同结果,症状复杂,病情繁多,患者日常生活标准急剧降低,对人类健康不断造成严重影响。无论是传统医学或现代研究,肾茶在治疗慢性肾衰竭方面一直成为焦点。临证治疗慢性肾衰竭时,常以肾茶为切入点,本文通过查阅文献主要从药物功能,药理作用,多方面应用(中药结肠灌肠、中药离子导入、中成药、纳米中药等),名家经验等方面对肾茶治疗慢性肾衰竭的研究概况进行简要归纳。Chronic renal failure (CRF) is the common result of the continuous progress of chronic kidney disease or other various cumulative systemic diseases complicated with the kidney. The symptoms are complex, the conditions are various, and the patients’ daily living standards are sharply reduced, which has a serious impact on human health. Whether traditional medicine or modern research, Clerodendranthus spicatus has always been the focus in the treatment of chronic renal failure. In clinical treatment of chronic renal failure, Clerodendranthus spicatus is often taken as the starting point. This article briefly summarizes the research situation of Clerodendranthus spicatus in treating chronic renal failure from the aspects of drug function, pharmacological effect, multiple applications (colon enema of traditional Chinese medicine, iontophoresis of traditional Chinese medicine, Chinese patent medicine, nano Chinese medicine, etc.), and famous experts’ experience.
文摘目的:基于咽–肠–肾轴理论探讨清咽健脾方加减治疗IgA肾病的效果。方法:IgA肾病是临床比较常见的一种原发性肾小球疾病,其主要症状为血尿,伴有不同程度的蛋白尿,高血压、肾病综合征等肾损害。电镜下表现为肾小球体积系膜区免疫复合物IgA的大量沉淀,或以IgA沉淀为主兼见补体C3等沉积。将从中西医两方面角度探讨咽–肠–肾轴理论的可行性及相关治疗方案异同,传统中医学认为,IgA发病责之于肺、脾、肾;西医目前相关主要理论有两点:一是肠肾轴理论,肠道菌群免疫功能在IgA肾病的发生及治疗中起重要作用,二是咽肾密切相关,咽喉为其纽带。本文通过对IgA肾病肠咽肾轴病机的阐释,相关病因阐述以及中西医对于本病的观点及当前治疗方案,并结合本汤药药物作用机制研究,从而进一步探讨清咽健脾方治疗IgA肾病的可行性。结论:基于咽–肠–肾轴理论探讨清咽健脾方治疗IgA肾病的效果良好,能够降低患者24 h尿蛋白定量及尿红细胞计数,有助于改善肾脏功能,延缓肾脏纤维化进展,值得临床采纳。Objective: To investigate the effect of Qingyan Jianpi decoction on IgA nephropathy based on the theory of pharyngoenteric-instine kidney axis. Methods: IgA nephropathy is a common primary glomerular disease. The main symptoms of IGA nephropathy are hematuria, proteinuria, hypertension, nephrotic syndrome and other renal damage. Under electron microscope, the immunocomplex IgA was deposited in the mesangial area of the glomerular volume, or IgA deposition was mainly accompanied by complement C3 deposition. The feasibility of the pharyngoentero-renal axis theory and the similarities and differences of related treatment schemes will be discussed from the perspectives of traditional Chinese and Western medicine. Traditional Chinese medicine believes that the pathogenesis of IgA is the lung, spleen and kidney. At present, there are two main theories related to Western medicine: Firstly, the enterorenal axis theory which means the immune function of intestinal flora plays an important role in the occurrence and development of IgA nephropathy;secondly, the kidney and throat are connected closely, and the throat is its link. In this paper, through the explanation of the pathogenesis of enteropharyngorenal axis of IgA nephropathy, together with the related etiology, and the views of traditional Chinese and western medicine on this disease and the current treatment plan, we combine these with the study of the mechanism of action of this decoction, to further explore the feasibility of Qingyan Jianpi prescription for the treatment of IgA nephropathy. Conclusion: Based on the theory of pharyng-instine-kidney axis, Qingyan Jianpi formula has a significant effect on IgA nephropathy, which can reduce 24 h urinary protein quantity and urinary red blood cell count, and help to improve renal fibrosis, which is worthy of clinical adoption.
