【目的】探讨参苓白术散对代谢综合征(MS)大鼠的治疗作用及机制。【方法】将40只大鼠分为正常组(10只)和造模组(30只)。造模组大鼠采用高脂高糖高盐饲料喂养方法构建MS模型。将造模成功的21只MS大鼠随机分为模型组(7只)、中药组(7只)、...【目的】探讨参苓白术散对代谢综合征(MS)大鼠的治疗作用及机制。【方法】将40只大鼠分为正常组(10只)和造模组(30只)。造模组大鼠采用高脂高糖高盐饲料喂养方法构建MS模型。将造模成功的21只MS大鼠随机分为模型组(7只)、中药组(7只)、西药组(7只),正常组纳进大鼠9只。中药组给予参苓白术散水煎液灌胃,西药组给予盐酸二甲双胍生理盐水溶液灌胃,正常组和模型组给予等体积的生理盐水灌胃,治疗时间为4周。给药结束后,检测大鼠体质量、腹围、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂肪酸(FFA),计算稳态模型评估的胰岛素抵抗指数(HOMA-IR)、肥胖指数、Lee’s指数;酶联免疫吸附分析(ELISA)检测大鼠血清肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)、白细胞介素8(IL-8);实时定量聚合酶链反应(QPCR)法检测肝脏NOD样受体蛋白3(NLRP3)、Toll样受体4(TLR4)、核转录因子κB(NF-κB)mRNA表达;苏木素-伊红(HE)染色法观察肝脏病理变化。【结果】与正常组比较,模型组大鼠体质量、腹围、肥胖指数、Lee’s指数、SBP、DBP、FPG、FINS、TC、TG、LDL-C、FFA、HOMA-IR、TNF-α、IL-1、IL-8水平均升高,HDL-C降低,肝脏NLRP3、TLR4、NF-κB m RNA表达水平均升高,HE染色结果显示肝脏脂肪变性和炎性细胞浸润;中药组上述各指标较模型组均得到明显改善(P<0.05),且与西药组比较,差异均无统计学意义(P>0.05)。【结论】参苓白术散可以有效改善MS大鼠糖脂代谢障碍、胰岛素抵抗,减轻肝脏脂肪变性和炎性细胞浸润,其机制可能与抑制炎症因子TNF-α、IL-1、IL-8释放及炎症反应相关基因NLRP3、TLR4、NF-κB mRNA的表达,进而减轻炎症状态有关。展开更多
Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are invest...Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are investigated.The results show that the system composed of gain materials exhibits characteristics of ultra-strong transmission and bidirectional reflection.Conversely,the system composed of loss materials demonstrates equal transmittance and reflectance at some frequencies.In both the systems,a new type of total reflection phenomenon is observed.When the imaginary part of the refractive indices of waveguide segments is smaller than 10-5,the system shows bidirectional transparency with the transmittance tending to be 1 and reflectivity to be smaller than 10-8 at some bands.When the refractive indices of the waveguide segments are real,the system will be bidirectional transparent at the full band.These findings may deepen the understanding of anti-PT-symmetric optical systems and optical waveguide networks,and possess potential applications in efficient optical energy storage,ultra-sensitive optical filters,ultra-sensitive all-optical switches,integrated optical chips,stealth physics,and so on.展开更多
文摘【目的】探讨参苓白术散对代谢综合征(MS)大鼠的治疗作用及机制。【方法】将40只大鼠分为正常组(10只)和造模组(30只)。造模组大鼠采用高脂高糖高盐饲料喂养方法构建MS模型。将造模成功的21只MS大鼠随机分为模型组(7只)、中药组(7只)、西药组(7只),正常组纳进大鼠9只。中药组给予参苓白术散水煎液灌胃,西药组给予盐酸二甲双胍生理盐水溶液灌胃,正常组和模型组给予等体积的生理盐水灌胃,治疗时间为4周。给药结束后,检测大鼠体质量、腹围、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂肪酸(FFA),计算稳态模型评估的胰岛素抵抗指数(HOMA-IR)、肥胖指数、Lee’s指数;酶联免疫吸附分析(ELISA)检测大鼠血清肿瘤坏死因子α(TNF-α)、白细胞介素1(IL-1)、白细胞介素8(IL-8);实时定量聚合酶链反应(QPCR)法检测肝脏NOD样受体蛋白3(NLRP3)、Toll样受体4(TLR4)、核转录因子κB(NF-κB)mRNA表达;苏木素-伊红(HE)染色法观察肝脏病理变化。【结果】与正常组比较,模型组大鼠体质量、腹围、肥胖指数、Lee’s指数、SBP、DBP、FPG、FINS、TC、TG、LDL-C、FFA、HOMA-IR、TNF-α、IL-1、IL-8水平均升高,HDL-C降低,肝脏NLRP3、TLR4、NF-κB m RNA表达水平均升高,HE染色结果显示肝脏脂肪变性和炎性细胞浸润;中药组上述各指标较模型组均得到明显改善(P<0.05),且与西药组比较,差异均无统计学意义(P>0.05)。【结论】参苓白术散可以有效改善MS大鼠糖脂代谢障碍、胰岛素抵抗,减轻肝脏脂肪变性和炎性细胞浸润,其机制可能与抑制炎症因子TNF-α、IL-1、IL-8释放及炎症反应相关基因NLRP3、TLR4、NF-κB mRNA的表达,进而减轻炎症状态有关。
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11674107,61475049,11775083,61774062,and 61771205).
文摘Two types of one-dimensional(1D)anti-PT-symmetric periodic ring optical waveguide networks,consisting of gain and loss materials,are constructed.The singular optical propagation properties of these networks are investigated.The results show that the system composed of gain materials exhibits characteristics of ultra-strong transmission and bidirectional reflection.Conversely,the system composed of loss materials demonstrates equal transmittance and reflectance at some frequencies.In both the systems,a new type of total reflection phenomenon is observed.When the imaginary part of the refractive indices of waveguide segments is smaller than 10-5,the system shows bidirectional transparency with the transmittance tending to be 1 and reflectivity to be smaller than 10-8 at some bands.When the refractive indices of the waveguide segments are real,the system will be bidirectional transparent at the full band.These findings may deepen the understanding of anti-PT-symmetric optical systems and optical waveguide networks,and possess potential applications in efficient optical energy storage,ultra-sensitive optical filters,ultra-sensitive all-optical switches,integrated optical chips,stealth physics,and so on.
