目的:了解西安市儿童医院呼吸一科因呼吸道感染住院患儿的呼吸道合胞病毒流行病学特征,为本地区呼吸道合胞病毒感染的临床诊疗及预防提供依据。方法:回顾性分析2020年1月1日~2023年12月31日,4年间因呼吸道合胞病毒感染在西安市儿童医院...目的:了解西安市儿童医院呼吸一科因呼吸道感染住院患儿的呼吸道合胞病毒流行病学特征,为本地区呼吸道合胞病毒感染的临床诊疗及预防提供依据。方法:回顾性分析2020年1月1日~2023年12月31日,4年间因呼吸道合胞病毒感染在西安市儿童医院呼吸一科住院患儿为研究对象,并对结果进行分析。结果:纳入在西安市儿童医院呼吸一科住院的7363例呼吸道感染患者中呼吸道合胞病毒阳性病例628例,总阳性率为8.53%。RSV感染患儿在≤1岁年龄组检出率最高,占比为14.62% (333/2277),随着年龄增加,阳性率也逐渐下降。不同性别患者的RSV阳性率差异无统计学意义(P > 0.05)。这4年期间,春季、夏季、秋季、冬季RSV的阳性检出率有明显差异,前3年RSV流行月份多在冬季,其次为秋季,但2023年间RSV流行月份多在春季,其次为夏季。在RSV感染阳性患儿中,不同年份的重症RSV感染患儿分布也具有明显差异性(P = 0.000 P = 0.163 > 0.05);重症患者在≤1岁组比例最高,差异有统计学意义(P Objective: To investigate the epidemiological characteristics of respiratory syncytial virus (RSV) in children with respiratory infection in Department 1 of Xi’an Children’s Hospital, and to provide evidence for clinical diagnosis, treatment and prevention of RSV infection in this area. Methods: From January 1, 2020 to December 31, 2023, children hospitalized with respiratory syncytial virus infection in Department 1 of Xi’an Children’s Hospital during 4 years were analyzed retrospectively, and the results were analyzed. Results: Among 7363 patients, 628 were positive for RSV, with a total positive rate of 8.53%. The highest rate of RSV infection was in the age group ≤1 year, accounting for 14.62% (333/2277), and the positive rate decreased gradually with the increase of age. There was no significant difference in the positive rate of RSV among different genders (P > 0.05). During the four years, the positive detection rates of RSV from March to May, June to August, September to November, and December to February of the same year were significantly different. In the first three years, the prevalence months of RSV were mostly from December to February, followed by September to November, but in 2023, the prevalence months of RSV were mostly from March to May, and the three times were from June to August. Among RSV positive children, the distribution of severe RSV infection in different years was also significantly different (P = 0.000 P = 0.163 > 0.05). The proportion of severe cases in ≤1 year old group was the highest, and the difference was statistically significant (P < 0.05). There were 108 cases of mixed infection with RSV-positive infection, 96 cases with single pathogen, 9 cases with double pathogen, and 3 cases with 3 pathogens. Mycoplasma pneumoniae was the most common mixed infection. Children with RSV infection often present cough, phlegm in the throat, and pulmonary signs are mostly wheezing and moist rales. The most common comorbidities are myocardial damage and occasional rash. Conclusion: RSV is a common pathogen causing respiratory tract infection in infants and young children, and the clinical protection should be strengthened.展开更多
白藜芦醇(Resveratrol)是一种天然存在于葡萄、浆果和花生中的多酚化合物,因其显著的抗氧化、抗炎和抗癌特性,近年来在乳腺癌研究中备受关注。文章综述了白藜芦醇在乳腺癌细胞中的分子机制及其在抗肿瘤过程中的作用。白藜芦醇通过靶向...白藜芦醇(Resveratrol)是一种天然存在于葡萄、浆果和花生中的多酚化合物,因其显著的抗氧化、抗炎和抗癌特性,近年来在乳腺癌研究中备受关注。文章综述了白藜芦醇在乳腺癌细胞中的分子机制及其在抗肿瘤过程中的作用。白藜芦醇通过靶向多种信号分子,抑制乳腺癌细胞的增殖,诱导细胞凋亡和自噬,抑制细胞迁移和侵袭,并重组细胞代谢。此外,白藜芦醇与化疗和放疗药物具有协同作用的潜力。尽管临床前研究结果令人鼓舞,但白藜芦醇的生物利用度和稳定性问题仍需解决。未来的研究应聚焦于优化白藜芦醇的递送系统,深入揭示其分子作用机制,并评估其长期使用的安全性和有效性,为乳腺癌患者提供更有效的治疗选择。Resveratrol, a polyphenolic compound naturally found in grapes, berries, and peanuts, has attracted significant attention in recent years due to its potent antioxidant, anti-inflammatory, and anti-cancer properties. This review summarizes the molecular mechanisms of resveratrol in breast cancer cells and its role in tumor suppression. Resveratrol exerts its effects by targeting multiple signaling molecules, thereby inhibiting the proliferation of breast cancer cells, inducing apoptosis and autophagy, suppressing cell migration and invasion, and reprogramming cellular metabolism. Additionally, resveratrol shows potential synergistic effects when combined with chemotherapeutic and radiotherapeutic agents. Despite promising preclinical results, issues related to the bioavailability and stability of resveratrol remain to be addressed. Future research should focus on optimizing resveratrol delivery systems, deeply elucidating its molecular mechanisms, and evaluating the safety and efficacy of long-term use, with the ultimate goal of providing more effective treatment options for breast cancer patients.展开更多
目的：研究血清可溶性CD40配体（sCD40L）和白细胞介素18（IL-18）水平与脑梗死的关系。方法：选择2012年5月~2014年12月于我院就诊的脑梗死患者70例纳入脑梗死组,同一时间段内在我院体检中心体检的70例健康志愿者纳入研究的健康组,分...目的：研究血清可溶性CD40配体（sCD40L）和白细胞介素18（IL-18）水平与脑梗死的关系。方法：选择2012年5月~2014年12月于我院就诊的脑梗死患者70例纳入脑梗死组,同一时间段内在我院体检中心体检的70例健康志愿者纳入研究的健康组,分离血清并测定sCD40L、IL-18、细胞黏附分子1（ICAM-1）、血管细胞黏附分子1（VCAM-1）、CD11b、CD18、基质金属蛋白酶（MMP）10、解聚素-金属蛋白酶17（ADAM17）、ADAMTS12的含量,分离外周血单个核细胞并测定CD40、CD40L、NLRP3、凋亡相关点样蛋白（apoptotic speck-like protein containing a caspase recruitment domain,ASC）、Caspase-1的含量。结果：脑梗死组患者血清中sCD40L、IL-18、ICAM-1、VCAM-1、CD11b、CD18、MMP10、ADAM17、ADAMTS12的含量以及外周血中CD40、CD40L、NLRP3、ASC、Caspase-1的表达量显著高于健康组（P〈0.05）;脑梗死患者的神经功能缺损越严重,血清中sCD40L、IL-18的含量以及外周血中CD40、CD40L、NLRP3、ASC、Caspase-1的表达量越高（P〈0.05）;sCD40L、IL-18高水平组脑梗死患者血清中ICAM-1、VCAM-1、CD11b、CD18、MMP10、ADAM17、ADAMTS-12的含量显著高于低水平组（P〈0.05）。结论：血清可溶性CD40配体和白细胞介素18水平升高与脑梗死的发生以及病情严重程度相关。展开更多
文摘目的:了解西安市儿童医院呼吸一科因呼吸道感染住院患儿的呼吸道合胞病毒流行病学特征,为本地区呼吸道合胞病毒感染的临床诊疗及预防提供依据。方法:回顾性分析2020年1月1日~2023年12月31日,4年间因呼吸道合胞病毒感染在西安市儿童医院呼吸一科住院患儿为研究对象,并对结果进行分析。结果:纳入在西安市儿童医院呼吸一科住院的7363例呼吸道感染患者中呼吸道合胞病毒阳性病例628例,总阳性率为8.53%。RSV感染患儿在≤1岁年龄组检出率最高,占比为14.62% (333/2277),随着年龄增加,阳性率也逐渐下降。不同性别患者的RSV阳性率差异无统计学意义(P > 0.05)。这4年期间,春季、夏季、秋季、冬季RSV的阳性检出率有明显差异,前3年RSV流行月份多在冬季,其次为秋季,但2023年间RSV流行月份多在春季,其次为夏季。在RSV感染阳性患儿中,不同年份的重症RSV感染患儿分布也具有明显差异性(P = 0.000 P = 0.163 > 0.05);重症患者在≤1岁组比例最高,差异有统计学意义(P Objective: To investigate the epidemiological characteristics of respiratory syncytial virus (RSV) in children with respiratory infection in Department 1 of Xi’an Children’s Hospital, and to provide evidence for clinical diagnosis, treatment and prevention of RSV infection in this area. Methods: From January 1, 2020 to December 31, 2023, children hospitalized with respiratory syncytial virus infection in Department 1 of Xi’an Children’s Hospital during 4 years were analyzed retrospectively, and the results were analyzed. Results: Among 7363 patients, 628 were positive for RSV, with a total positive rate of 8.53%. The highest rate of RSV infection was in the age group ≤1 year, accounting for 14.62% (333/2277), and the positive rate decreased gradually with the increase of age. There was no significant difference in the positive rate of RSV among different genders (P > 0.05). During the four years, the positive detection rates of RSV from March to May, June to August, September to November, and December to February of the same year were significantly different. In the first three years, the prevalence months of RSV were mostly from December to February, followed by September to November, but in 2023, the prevalence months of RSV were mostly from March to May, and the three times were from June to August. Among RSV positive children, the distribution of severe RSV infection in different years was also significantly different (P = 0.000 P = 0.163 > 0.05). The proportion of severe cases in ≤1 year old group was the highest, and the difference was statistically significant (P < 0.05). There were 108 cases of mixed infection with RSV-positive infection, 96 cases with single pathogen, 9 cases with double pathogen, and 3 cases with 3 pathogens. Mycoplasma pneumoniae was the most common mixed infection. Children with RSV infection often present cough, phlegm in the throat, and pulmonary signs are mostly wheezing and moist rales. The most common comorbidities are myocardial damage and occasional rash. Conclusion: RSV is a common pathogen causing respiratory tract infection in infants and young children, and the clinical protection should be strengthened.
文摘白藜芦醇(Resveratrol)是一种天然存在于葡萄、浆果和花生中的多酚化合物,因其显著的抗氧化、抗炎和抗癌特性,近年来在乳腺癌研究中备受关注。文章综述了白藜芦醇在乳腺癌细胞中的分子机制及其在抗肿瘤过程中的作用。白藜芦醇通过靶向多种信号分子,抑制乳腺癌细胞的增殖,诱导细胞凋亡和自噬,抑制细胞迁移和侵袭,并重组细胞代谢。此外,白藜芦醇与化疗和放疗药物具有协同作用的潜力。尽管临床前研究结果令人鼓舞,但白藜芦醇的生物利用度和稳定性问题仍需解决。未来的研究应聚焦于优化白藜芦醇的递送系统,深入揭示其分子作用机制,并评估其长期使用的安全性和有效性,为乳腺癌患者提供更有效的治疗选择。Resveratrol, a polyphenolic compound naturally found in grapes, berries, and peanuts, has attracted significant attention in recent years due to its potent antioxidant, anti-inflammatory, and anti-cancer properties. This review summarizes the molecular mechanisms of resveratrol in breast cancer cells and its role in tumor suppression. Resveratrol exerts its effects by targeting multiple signaling molecules, thereby inhibiting the proliferation of breast cancer cells, inducing apoptosis and autophagy, suppressing cell migration and invasion, and reprogramming cellular metabolism. Additionally, resveratrol shows potential synergistic effects when combined with chemotherapeutic and radiotherapeutic agents. Despite promising preclinical results, issues related to the bioavailability and stability of resveratrol remain to be addressed. Future research should focus on optimizing resveratrol delivery systems, deeply elucidating its molecular mechanisms, and evaluating the safety and efficacy of long-term use, with the ultimate goal of providing more effective treatment options for breast cancer patients.
文摘目的：研究血清可溶性CD40配体（sCD40L）和白细胞介素18（IL-18）水平与脑梗死的关系。方法：选择2012年5月~2014年12月于我院就诊的脑梗死患者70例纳入脑梗死组,同一时间段内在我院体检中心体检的70例健康志愿者纳入研究的健康组,分离血清并测定sCD40L、IL-18、细胞黏附分子1（ICAM-1）、血管细胞黏附分子1（VCAM-1）、CD11b、CD18、基质金属蛋白酶（MMP）10、解聚素-金属蛋白酶17（ADAM17）、ADAMTS12的含量,分离外周血单个核细胞并测定CD40、CD40L、NLRP3、凋亡相关点样蛋白（apoptotic speck-like protein containing a caspase recruitment domain,ASC）、Caspase-1的含量。结果：脑梗死组患者血清中sCD40L、IL-18、ICAM-1、VCAM-1、CD11b、CD18、MMP10、ADAM17、ADAMTS12的含量以及外周血中CD40、CD40L、NLRP3、ASC、Caspase-1的表达量显著高于健康组（P〈0.05）;脑梗死患者的神经功能缺损越严重,血清中sCD40L、IL-18的含量以及外周血中CD40、CD40L、NLRP3、ASC、Caspase-1的表达量越高（P〈0.05）;sCD40L、IL-18高水平组脑梗死患者血清中ICAM-1、VCAM-1、CD11b、CD18、MMP10、ADAM17、ADAMTS-12的含量显著高于低水平组（P〈0.05）。结论：血清可溶性CD40配体和白细胞介素18水平升高与脑梗死的发生以及病情严重程度相关。
