The four fluorescence coumarine derivatives were synthesized by reaction of bromo alkene and 7-hydroxyl coumarin.Their structures were characterized by IR,1HNMR,13CNMR and MS.UV-visible spectra and fluorescence spectr...The four fluorescence coumarine derivatives were synthesized by reaction of bromo alkene and 7-hydroxyl coumarin.Their structures were characterized by IR,1HNMR,13CNMR and MS.UV-visible spectra and fluorescence spectra showed that they have strong fluorescence.It was also showed that these derivatives exhibit excellent stability through the cyclic voltammograms.展开更多
目的:探讨广东省中山地区临床诊断为恙虫病患者的临床和流行病学特征,为早期诊断及防治提供依据。方法对198例恙虫病从流行病学、主要临床表现、实验室及影像学检查、治疗等方面进行分析。结果中山地区恙虫病发病例数逐年上升,发病...目的:探讨广东省中山地区临床诊断为恙虫病患者的临床和流行病学特征,为早期诊断及防治提供依据。方法对198例恙虫病从流行病学、主要临床表现、实验室及影像学检查、治疗等方面进行分析。结果中山地区恙虫病发病例数逐年上升,发病时间主要集中在5~10月份(91.4%),发病年龄以40~70岁年龄段最多(66.7%),职业构成以农民居多(31.8%),大多数(92.9%)患者有草地等野外活动史,常见表现为发热(100%),焦痂或溃疡(93.9%),实验室检查变形杆菌外斐凝集反应均阴性(100%),多数患者出现肝功能损害为丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)升高(95%以上)及白蛋白(ALB)减少(80.3%),显示肾损害尿蛋白和尿红细胞(53.0%),炎症反应指标降钙素原(PCT)升高(81.6%)以及嗜酸性粒细胞(EO)计数为0占62.1%,胸部 X 光片提示肺损害的肺部渗出性病变或肺膜炎改变(51.0%),合并两个或以上器官损害达85.4%,多器官功能障碍综合征(MODS)为8.6%。首诊确诊率为68.2%,病死率1.5%。结论恙虫病临床表现复杂多样,常合并多器官损害,并发症多,容易误诊,因此提高认识,早期诊治和加强高危人群健康教育,有利于改善预后和预防控制恙虫病的发生及流行。展开更多
文摘The four fluorescence coumarine derivatives were synthesized by reaction of bromo alkene and 7-hydroxyl coumarin.Their structures were characterized by IR,1HNMR,13CNMR and MS.UV-visible spectra and fluorescence spectra showed that they have strong fluorescence.It was also showed that these derivatives exhibit excellent stability through the cyclic voltammograms.
文摘目的:探讨广东省中山地区临床诊断为恙虫病患者的临床和流行病学特征,为早期诊断及防治提供依据。方法对198例恙虫病从流行病学、主要临床表现、实验室及影像学检查、治疗等方面进行分析。结果中山地区恙虫病发病例数逐年上升,发病时间主要集中在5~10月份(91.4%),发病年龄以40~70岁年龄段最多(66.7%),职业构成以农民居多(31.8%),大多数(92.9%)患者有草地等野外活动史,常见表现为发热(100%),焦痂或溃疡(93.9%),实验室检查变形杆菌外斐凝集反应均阴性(100%),多数患者出现肝功能损害为丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)升高(95%以上)及白蛋白(ALB)减少(80.3%),显示肾损害尿蛋白和尿红细胞(53.0%),炎症反应指标降钙素原(PCT)升高(81.6%)以及嗜酸性粒细胞(EO)计数为0占62.1%,胸部 X 光片提示肺损害的肺部渗出性病变或肺膜炎改变(51.0%),合并两个或以上器官损害达85.4%,多器官功能障碍综合征(MODS)为8.6%。首诊确诊率为68.2%,病死率1.5%。结论恙虫病临床表现复杂多样,常合并多器官损害,并发症多,容易误诊,因此提高认识,早期诊治和加强高危人群健康教育,有利于改善预后和预防控制恙虫病的发生及流行。