Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal c...Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal carcinoma were prospectively enrolled.MR scanning,including three-dimensional liver acquisition with volume acceleration-flexible(3D LAVA_Flex)image,T2WI with fat suppression(T2WI-FS),T1WI,contrast enhancement(CE)T1WI-FS of nasopharynx and neck region were performed.The displaying rates of CN PNS were evaluated and compared between 3D LAVA_Flex and T2WI-FS,T1WI,CE-T1WI-FS at patient level,CN group level and neural level,respectively.Results The displaying rate of CN PNS in all 87 nasopharyngeal carcinoma patients by 3D LAVA_Flex sequence was 49.43%(43/87),higher than that of conventional MRI(30/87,34.48%,P=0.001).Among 59 patients with advanced nasopharyngeal carcinoma diagnosed with conventional sequences,the displaying rate of CN PNS was 71.19%(42/59)by 3D LAVA-Flex sequence,higher than that of conventional MRI(30/59,50.85%,P=0.001).At both patient level and posterior CN level,significant differences of the displaying rate of CN PNS were found between 3D LAVA-Flex sequence and T2WI-FS,T1WI,CE-T1WI-FS,while at CN level,the displaying rates of mandibular nerve PNS,CNⅨ—ⅪPNS in jugular foramen(P<0.05)and CNⅨ—ⅫPNS in carotid space of 3D LAVA_Flex sequence were all significantly higher than that of T2WI-FS,T1WI and CE-T1WI-FS(all P<0.05),of PNS of CNⅢ—Ⅴin cavernous sinus were higher than that of T2WI-FS(P<0.05),while of PNS of hypoglossal nerve were significantly higher than that of T2WI-FS and T1WI(both P<0.05).Conclusion 3D LAVA_Flex sequence could be used to effectively display CN PNS of nasopharyngeal carcinoma.展开更多
目的探讨牙种植体周围龈沟液中可溶性髓样细胞触发性受体-1(soluble triggering receptor expressed on myeloid cell,sTREM-1)的水平与种植体周围炎的关系。方法收集2013年1月—2016年12月在莆田学院附属医院行牙种植术后出现不同程度...目的探讨牙种植体周围龈沟液中可溶性髓样细胞触发性受体-1(soluble triggering receptor expressed on myeloid cell,sTREM-1)的水平与种植体周围炎的关系。方法收集2013年1月—2016年12月在莆田学院附属医院行牙种植术后出现不同程度牙种植体周围炎的46名患者(种植体75颗)为研究对象,选取同期来院行牙种植术后种植体周围组织健康的患者18名(种植体25颗)为对照组。收集种植体周围龈沟液,采用ELISA法检测龈沟液样本中sTREM-1的浓度,记录种植体周围袋深度(peri-implantitis peroxidase depth,PPD)、种植体周牙槽骨丧失深度(The distance from the shoulder of the implant to the bottom of the bony defect,DSB)、改良龈沟出血指数(modified sulcus bleeding index,m SBI)和改良菌斑指数(modified plaque index,m PLI);分析种植体周围PPD、DSB、mSBI、mPLI和sTREM-1的相关性。结果轻度、中度、重度种植体周围炎龈沟液中sTREM-1的浓度均高于健康组(P<0.05);重度种植体周围炎龈沟液中sTREM-1的浓度高于轻度和中度种植体周围炎组(P<0.05);轻度和中度种植体周围炎龈沟液中sTREM-1的浓度差异无统计学意见(P>0.05)。sTREM-1的浓度与植体周围PPD、DSB、mSBI、mPLI均呈正相关。结论种植体周围炎龈沟液中sTREM-1的浓度与种植体周围组织的炎症程度密切相关,随着组织炎症严重程度的增加而升高。展开更多
文摘Objective To observe the value of isotropic volumetric MRI for displaying perineural spread(PNS)of cranial nerve(CN)in nasopharyngeal carcinoma.Methods Eighty-seven patients with pathologically proven nasopharyngeal carcinoma were prospectively enrolled.MR scanning,including three-dimensional liver acquisition with volume acceleration-flexible(3D LAVA_Flex)image,T2WI with fat suppression(T2WI-FS),T1WI,contrast enhancement(CE)T1WI-FS of nasopharynx and neck region were performed.The displaying rates of CN PNS were evaluated and compared between 3D LAVA_Flex and T2WI-FS,T1WI,CE-T1WI-FS at patient level,CN group level and neural level,respectively.Results The displaying rate of CN PNS in all 87 nasopharyngeal carcinoma patients by 3D LAVA_Flex sequence was 49.43%(43/87),higher than that of conventional MRI(30/87,34.48%,P=0.001).Among 59 patients with advanced nasopharyngeal carcinoma diagnosed with conventional sequences,the displaying rate of CN PNS was 71.19%(42/59)by 3D LAVA-Flex sequence,higher than that of conventional MRI(30/59,50.85%,P=0.001).At both patient level and posterior CN level,significant differences of the displaying rate of CN PNS were found between 3D LAVA-Flex sequence and T2WI-FS,T1WI,CE-T1WI-FS,while at CN level,the displaying rates of mandibular nerve PNS,CNⅨ—ⅪPNS in jugular foramen(P<0.05)and CNⅨ—ⅫPNS in carotid space of 3D LAVA_Flex sequence were all significantly higher than that of T2WI-FS,T1WI and CE-T1WI-FS(all P<0.05),of PNS of CNⅢ—Ⅴin cavernous sinus were higher than that of T2WI-FS(P<0.05),while of PNS of hypoglossal nerve were significantly higher than that of T2WI-FS and T1WI(both P<0.05).Conclusion 3D LAVA_Flex sequence could be used to effectively display CN PNS of nasopharyngeal carcinoma.
文摘目的探讨牙种植体周围龈沟液中可溶性髓样细胞触发性受体-1(soluble triggering receptor expressed on myeloid cell,sTREM-1)的水平与种植体周围炎的关系。方法收集2013年1月—2016年12月在莆田学院附属医院行牙种植术后出现不同程度牙种植体周围炎的46名患者(种植体75颗)为研究对象,选取同期来院行牙种植术后种植体周围组织健康的患者18名(种植体25颗)为对照组。收集种植体周围龈沟液,采用ELISA法检测龈沟液样本中sTREM-1的浓度,记录种植体周围袋深度(peri-implantitis peroxidase depth,PPD)、种植体周牙槽骨丧失深度(The distance from the shoulder of the implant to the bottom of the bony defect,DSB)、改良龈沟出血指数(modified sulcus bleeding index,m SBI)和改良菌斑指数(modified plaque index,m PLI);分析种植体周围PPD、DSB、mSBI、mPLI和sTREM-1的相关性。结果轻度、中度、重度种植体周围炎龈沟液中sTREM-1的浓度均高于健康组(P<0.05);重度种植体周围炎龈沟液中sTREM-1的浓度高于轻度和中度种植体周围炎组(P<0.05);轻度和中度种植体周围炎龈沟液中sTREM-1的浓度差异无统计学意见(P>0.05)。sTREM-1的浓度与植体周围PPD、DSB、mSBI、mPLI均呈正相关。结论种植体周围炎龈沟液中sTREM-1的浓度与种植体周围组织的炎症程度密切相关,随着组织炎症严重程度的增加而升高。
