The possible transduction mechanisms involved in ischemic preconditioning were reviewed briefly,Nitric oxide from the endothelium (and possible also from cardiac myocytes)by the action of bradykinin stimulates soluble...The possible transduction mechanisms involved in ischemic preconditioning were reviewed briefly,Nitric oxide from the endothelium (and possible also from cardiac myocytes)by the action of bradykinin stimulates soluble guanylate cyclase in the cytosol resulting in an elevation of cGMP. This may inhibit the inward slow Ca2+ current by stimulating a cGMP-dependent PDE’ to decrease cGMP levels. The translocation of PKC to membrane by DAG formation resulting from the activation of PLC phosphorylates a membrane protein that may link to the ATP-dependent K+ channel. The pathway may be stimulated by the adenosine A, receptors,muscarine acetylcholine M1, M3 and M5 receptors and a-adrenoceptors as well. The possible approaches for pharmacological exploitation are to minic the endogenous myocardial protective mediators by more selective and long acting analogues, to enhence these mediators by modulating their release, transport and uptake, to modulate myocardial cAMP and cGMP levels,to target guanine-nucleotide binding regulatory proteins and etc.展开更多
注射用血凝酶（hemocoagulase atrox for injection）是含有自巴西矛头蝮蛇（bothrops atrox）蛇毒的组分血凝酶和磷脂依赖性凝血因子Ⅹ激活物（简称Ⅹ因子激活物FⅩa）的蛇毒制剂,其起主要作用的是可广泛用于需减少流血或止血的各种医...注射用血凝酶（hemocoagulase atrox for injection）是含有自巴西矛头蝮蛇（bothrops atrox）蛇毒的组分血凝酶和磷脂依赖性凝血因子Ⅹ激活物（简称Ⅹ因子激活物FⅩa）的蛇毒制剂,其起主要作用的是可广泛用于需减少流血或止血的各种医疗情况,如临床各科室的出血和出血性疾病;也可用来预防出血,如手术前用药,可避免或减少手术部位及手术后出血[1]。为了合理使用注射用血凝酶,现将与血凝酶、磷脂依赖性凝血因子Ⅹ激活物和血液凝固等有关的基本慨念和基础理论知识简述如下。展开更多
2010年1月出版的,由凌沛学教授主编,张天民教授和陈祖基教授主审的《眼科药物与制剂学（Ophthalmic Drugs and Preparation Techniques）》是一本集眼科药物的生理学、药理学、药物学、临床应用、制剂学、工艺学之大成的新精著。在国内...2010年1月出版的,由凌沛学教授主编,张天民教授和陈祖基教授主审的《眼科药物与制剂学（Ophthalmic Drugs and Preparation Techniques）》是一本集眼科药物的生理学、药理学、药物学、临床应用、制剂学、工艺学之大成的新精著。在国内不多见。展开更多
文摘The possible transduction mechanisms involved in ischemic preconditioning were reviewed briefly,Nitric oxide from the endothelium (and possible also from cardiac myocytes)by the action of bradykinin stimulates soluble guanylate cyclase in the cytosol resulting in an elevation of cGMP. This may inhibit the inward slow Ca2+ current by stimulating a cGMP-dependent PDE’ to decrease cGMP levels. The translocation of PKC to membrane by DAG formation resulting from the activation of PLC phosphorylates a membrane protein that may link to the ATP-dependent K+ channel. The pathway may be stimulated by the adenosine A, receptors,muscarine acetylcholine M1, M3 and M5 receptors and a-adrenoceptors as well. The possible approaches for pharmacological exploitation are to minic the endogenous myocardial protective mediators by more selective and long acting analogues, to enhence these mediators by modulating their release, transport and uptake, to modulate myocardial cAMP and cGMP levels,to target guanine-nucleotide binding regulatory proteins and etc.
文摘注射用血凝酶（hemocoagulase atrox for injection）是含有自巴西矛头蝮蛇（bothrops atrox）蛇毒的组分血凝酶和磷脂依赖性凝血因子Ⅹ激活物（简称Ⅹ因子激活物FⅩa）的蛇毒制剂,其起主要作用的是可广泛用于需减少流血或止血的各种医疗情况,如临床各科室的出血和出血性疾病;也可用来预防出血,如手术前用药,可避免或减少手术部位及手术后出血[1]。为了合理使用注射用血凝酶,现将与血凝酶、磷脂依赖性凝血因子Ⅹ激活物和血液凝固等有关的基本慨念和基础理论知识简述如下。
