Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, ...Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, or for patients with time-average proteinuria 〈 0.5 g/d. Methods A total of 173 patients with biopsy-confirmed IgA nephropathy diagnosed from January 2000 to December 2010 were included. All of these patients were followed up for more than 5 years. The endpoint was a 〉 30% of decline in eGFR from baseline after 5-year follow-up. The optimal cut-off value of GD was calculated by ROC curve. Kaplan-Meier method and Cox regression analysis was used for survival analysis. Results A 30% of decline in eGFR occurred in 14.5% of all patients. The optimal diagnostic cut-off value of GD was 1.99/mm2 （AUC = 0.90, sensitivity = 84.0%, specificity = 81.8%） determined by ROC curve. The low GD group （GD 〈 1.99 per mm2） experienced a significant increase in renal endpoint for patients with eGFR of 30 to 60 ml/min per 1.73 m2 （six patients in lower GD group, while one patient in the other group）. For patients with time-average proteinuria 〈 0.5 g/d, the lower GD group showed a higher eGFR decline from baseline （4.5±16.7 ml/min per 1.73 m2 vs. –8.1±21.4 ml/min per 1.73 m2, P = 0.038）; two patients in this group reached the endpoint, while no patients in the higher GD group did. Conclusion GD could be an independent prognostic factor for patients of IgA nephropathy with eGFR at 30 to 60 ml/min per 1.73 m2 of body surface, particularly for those with time-averaged amount of urine protein less than 0.5 g per day.展开更多
目的分析连续性高容量血液滤过(continuous high volume hemofiltration,CHVHF)对严重脓毒症患儿的疗效。方法选择2014年6月至2016年8月本院收治的严重脓毒症患儿47例为研究对象,根据患儿是否接受CHVHF治疗,将其分为研究组(24例)和对照...目的分析连续性高容量血液滤过(continuous high volume hemofiltration,CHVHF)对严重脓毒症患儿的疗效。方法选择2014年6月至2016年8月本院收治的严重脓毒症患儿47例为研究对象,根据患儿是否接受CHVHF治疗,将其分为研究组(24例)和对照组(23例)。对照组患儿采取综合治疗,研究组患儿在对照组基础上行床旁CHVHF治疗,连续观察72小时。比较治疗前和治疗24小时、48小时及72小时后两组患儿的氧合指数、血乳酸、血肌酐、血尿素氮、白介素(interleukin,IL)-6、IL-10、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)水平及治疗后并发症发生情况。结果治疗后两组患儿氧合指数、血乳酸、血肌酐、血尿素氮、IL-6、IL-10、TNF-α水平与治疗前比较均有显著差异(P<0.05)。治疗48小时和72小时后,研究组患儿氧合指数均显著高于对照组(P<0.05),血乳酸水平均显著低于对照组(P<0.05)。治疗24小时后,研究组患儿血肌酐水平显著低于对照组(P<0.05)。治疗72小时后,研究组患儿IL-6水平显著低于对照组(P<0.05)。治疗48小时和72小时后,研究组患儿IL-10水平均显著低于对照组(P<0.05)。治疗24、48、72小时后,研究组患儿TNF-α水平均显著低于对照组(P<0.05)。研究组患儿并发症发生率显著低于对照组(χ~2=7.6855,P=0.0056)。结论 CHVHF对严重脓毒症患儿的疗效较好,安全性较佳。展开更多
基金Supported by the Key Projects in the National Science and Technology Pillar Program During the Twelfth Five-year Plan Period(2011BAI10B03)
文摘Objective To investigate whether glomerular density （GD） could be an independent prognostic factor for patients of IgA nephropathy with estimated glomerular filtration rate （eGFR） of 30 to 60 ml/min per 1.73 m2, or for patients with time-average proteinuria 〈 0.5 g/d. Methods A total of 173 patients with biopsy-confirmed IgA nephropathy diagnosed from January 2000 to December 2010 were included. All of these patients were followed up for more than 5 years. The endpoint was a 〉 30% of decline in eGFR from baseline after 5-year follow-up. The optimal cut-off value of GD was calculated by ROC curve. Kaplan-Meier method and Cox regression analysis was used for survival analysis. Results A 30% of decline in eGFR occurred in 14.5% of all patients. The optimal diagnostic cut-off value of GD was 1.99/mm2 （AUC = 0.90, sensitivity = 84.0%, specificity = 81.8%） determined by ROC curve. The low GD group （GD 〈 1.99 per mm2） experienced a significant increase in renal endpoint for patients with eGFR of 30 to 60 ml/min per 1.73 m2 （six patients in lower GD group, while one patient in the other group）. For patients with time-average proteinuria 〈 0.5 g/d, the lower GD group showed a higher eGFR decline from baseline （4.5±16.7 ml/min per 1.73 m2 vs. –8.1±21.4 ml/min per 1.73 m2, P = 0.038）; two patients in this group reached the endpoint, while no patients in the higher GD group did. Conclusion GD could be an independent prognostic factor for patients of IgA nephropathy with eGFR at 30 to 60 ml/min per 1.73 m2 of body surface, particularly for those with time-averaged amount of urine protein less than 0.5 g per day.
