Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone for...Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation properties.In this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate bioceramics.These findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate bioceramics.This correlation was subsequently validated through degradation experiments.Furthermore,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of bioceramics.This discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.展开更多
目的探讨2型糖尿病患者使用糖尿病数字化管理APP进行血糖管理的使用效果。方法将226例2型糖尿病患者按随机数字法分为空白组(C1组,54例)、空白+电话提醒组(C2组,58例)、APP组(T1组,55例)、APP+电话提醒组(T2组,59例)4个组。在干预前及...目的探讨2型糖尿病患者使用糖尿病数字化管理APP进行血糖管理的使用效果。方法将226例2型糖尿病患者按随机数字法分为空白组(C1组,54例)、空白+电话提醒组(C2组,58例)、APP组(T1组,55例)、APP+电话提醒组(T2组,59例)4个组。在干预前及干预后3个月时收集4组患者的糖化血红蛋白(glycosylated hemoglobin,HbA1c)、血压、体质量指数(body mass index,BMI),干预后统计血糖监测频次。结果4组患者干预后HbA1c、BMI较基线均下降,差异有统计学意义(P<0.05);T1、T2组HbA1c达标率高于C1、C2组,但组间比较差异无统计学意义(P>0.05)。收缩压存在组间差异(P<0.05),T1、T2组收缩压低于C1组,T2组收缩压低于C2组,糖尿病数字化管理APP降低了收缩压(P<0.05)。C2、T2组自我血糖监测患者比例高于C1、T1组,但组间比较差异无统计学意义(P>0.05)。结论2型糖尿病患者使用糖尿病数字化管理APP有提高HbA1c达标率的趋势、降低收缩压水平,糖尿病数字化管理APP与电话随访对2型糖尿病患者自我血糖监测没有差异。展开更多
基金National Key Research and Development Program of China (2023YFB3813000)National Natural Science Foundation of China (52272256)State Key Laboratory of Advanced Technology for Materials Synthesis and Processing (Wuhan University of Technology)(2022-KF-77)。
文摘Bioceramics have attracted extensive attention for bone defect repair due to their excellent bioactivity and degradability.However,challenges remain in matching the rate between bioceramic degradation and new bone formation,necessitating a deeper understanding of their degradation properties.In this study,density functional theory(DFT)calculations was employed to explore the structural and electronic characteristics of silicate bioceramics.These findings reveal a linear correlation between the maximum isosurface value of the valence band maximum(VBM_(Fmax))and the degradability of silicate bioceramics.This correlation was subsequently validated through degradation experiments.Furthermore,the investigation on phosphate bioceramics demonstrates the potential of this descriptor in predicting the degradability of a broader range of bioceramics.This discovery offers valuable insights into the degradation mechanism of bioceramics and holds promise for accelerating the design and development of bioceramics with controllable degradation.
文摘目的探讨2型糖尿病患者使用糖尿病数字化管理APP进行血糖管理的使用效果。方法将226例2型糖尿病患者按随机数字法分为空白组(C1组,54例)、空白+电话提醒组(C2组,58例)、APP组(T1组,55例)、APP+电话提醒组(T2组,59例)4个组。在干预前及干预后3个月时收集4组患者的糖化血红蛋白(glycosylated hemoglobin,HbA1c)、血压、体质量指数(body mass index,BMI),干预后统计血糖监测频次。结果4组患者干预后HbA1c、BMI较基线均下降,差异有统计学意义(P<0.05);T1、T2组HbA1c达标率高于C1、C2组,但组间比较差异无统计学意义(P>0.05)。收缩压存在组间差异(P<0.05),T1、T2组收缩压低于C1组,T2组收缩压低于C2组,糖尿病数字化管理APP降低了收缩压(P<0.05)。C2、T2组自我血糖监测患者比例高于C1、T1组,但组间比较差异无统计学意义(P>0.05)。结论2型糖尿病患者使用糖尿病数字化管理APP有提高HbA1c达标率的趋势、降低收缩压水平,糖尿病数字化管理APP与电话随访对2型糖尿病患者自我血糖监测没有差异。
