Gossip-Based Topology Management Protocol for Self-Organizing Overlays

Gossip-based protocols have attracted more and more attention because of their simplicity and reliability.They can be applied to large-scale overlays for solving problems such as topology management,information dissemination,and aggregation.However,previous works sample nodes by their indegrees,without considering the differences in capability among nodes,and result in losing global load balancing.This paper proposes a load balancing gossip protocol for self-organizing overlays-LBTMP(Load-Balancing Topology Management Protocol),which takes into account the differences in capability among nodes and real loads.The novel protocol takes remainder service ability as the determinant for node selection metric,making light loading nodes from local neighbor view as returned samples preferentially.In the meantime,LBTMP selects light loading nodes preferentially for topology information exchange,which can diffuse light loading nodes over the whole overlay more quickly.Simulations show that returned sample node selection is biased to light loading nodes in a global view,and the overlay tends to load balancing.

从态靶辨证角度运用靶方靶药治疗心血瘀阻型非瓣膜病房颤的疗效观察

【目的】观察从“态靶辨证”角度运用靶方、靶药治疗心血瘀阻型非瓣膜病永久性房颤的临床疗效。【方法】将120例心血瘀阻型非瓣膜病永久性房颤患者随机分为对照组和试验组,每组各60例。对照组给予西医常规治疗,试验组在对照组的基础上配合靶方、靶药治疗(靶方用血府逐瘀汤,靶药用丹参、人参、西洋参等),总疗程为12周。观察2组患者治疗前后中医证候积分、24 h平均心室率、房颤生活质量量表(AFEQT)评分及左房内径的变化情况,比较2组患者靶剂量琥珀酸美托洛尔缓释片的每日使用量及血栓栓塞事件发生情况,评价2组患者的临床疗效和安全性。【结果】(1)研究过程中,共脱失5例,最终共纳入115例,其中试验组58例,对照组57例。(2)治疗12周后,试验组的总有效率为94.8%(55/58),对照组为86.0%(49/57);组间比较(Mann-Whitney U检验),试验组的临床疗效明显优于对照组(P<0.01)。(3)治疗后,2组患者的中医证候总积分和24 h平均心室率均较治疗前明显降低(P<0.01),AFEQT评分均较治疗前明显升高(P<0.01),且试验组的中医证候总积分和24 h平均心室率的降低幅度及AFEQT评分的升高幅度均明显优于对照组(P<0.01)。(4)12周后,试验组琥珀酸美托洛尔缓释片的每日使用量为(85.17±32.09)mg,明显低于对照组的(107.92±33.91)mg,差异有统计学意义(P<0.01)。(5)治疗后,2组患者的左房内径比较差异无统计学意义(P>0.05),但差值比较差异有统计学意义(P<0.05),初步提示试验组的改善幅度有优于对照组的趋势。(6)研究过程中,2组患者均未出现血栓栓塞事件,也均未出现中度及重度出血事件。【结论】从“态靶辨证”角度运用靶方、靶药治疗心血瘀阻型非瓣膜病永久性房颤患者疗效确切,其疗效明显优于单纯西医常规治疗。