贫血是终末期肾病患者常见的并发症,严重影响患者的生活质量。重组人促红细胞生成素（recombinant human erythropietin,r-HuEPO）和铁剂的临床应用,已显著改善了大部分终末期肾病患者的贫血状态,明显改善患者生存率及生活质量,但有研...贫血是终末期肾病患者常见的并发症,严重影响患者的生活质量。重组人促红细胞生成素（recombinant human erythropietin,r-HuEPO）和铁剂的临床应用,已显著改善了大部分终末期肾病患者的贫血状态,明显改善患者生存率及生活质量,但有研究报道大约10%患者仍表现为难治性贫血,目前认为这与机体微炎性反应状态有关。展开更多
The acylation reactions of L α Lysophosphatidylcholine(Lyso PC) or L α Glycerophosphorylcholine.CdCl 2(GPC CdCl 2) with fatty acid bearing bulky aromatic group or corresponding anhydride have been investigated. The ...The acylation reactions of L α Lysophosphatidylcholine(Lyso PC) or L α Glycerophosphorylcholine.CdCl 2(GPC CdCl 2) with fatty acid bearing bulky aromatic group or corresponding anhydride have been investigated. The acylation of Lyso PC with fatty acid bearing bulky aromatic group in the presence of condensing reagent N,N ′ dicyclohexylcarbodiimide(DCC) and catalyst 4 ( N,N ′ dimethylamino) pyridine(DMAP) was found to be more convenient and more efficient than that of Lyso PC with the corresponding fatty acid anhydride prepared prior to acylation(yield 85% to 45%). The poor formation of anhydride from fatty acid is responsible largely for the low yield. It was found that the acylation reaction of Lyso PC or GPC CdCl 2 with fatty acid bearing bulky aromatic group could be accomplished in 85% and 74% yield respectively by using a fatty acid/Lyso PC(or GPC CdCl 2) molar ratio of 4, DMAP/Lyso PC(or GPC CdCl 2) molar ratio of 4 and DCC/fatty acid molar ratio of 0 6 (1 for the acylation of GPC CdCl 2). The procedures described provide significant improvements in yield over methods repor ted .展开更多
文摘贫血是终末期肾病患者常见的并发症,严重影响患者的生活质量。重组人促红细胞生成素（recombinant human erythropietin,r-HuEPO）和铁剂的临床应用,已显著改善了大部分终末期肾病患者的贫血状态,明显改善患者生存率及生活质量,但有研究报道大约10%患者仍表现为难治性贫血,目前认为这与机体微炎性反应状态有关。
文摘The acylation reactions of L α Lysophosphatidylcholine(Lyso PC) or L α Glycerophosphorylcholine.CdCl 2(GPC CdCl 2) with fatty acid bearing bulky aromatic group or corresponding anhydride have been investigated. The acylation of Lyso PC with fatty acid bearing bulky aromatic group in the presence of condensing reagent N,N ′ dicyclohexylcarbodiimide(DCC) and catalyst 4 ( N,N ′ dimethylamino) pyridine(DMAP) was found to be more convenient and more efficient than that of Lyso PC with the corresponding fatty acid anhydride prepared prior to acylation(yield 85% to 45%). The poor formation of anhydride from fatty acid is responsible largely for the low yield. It was found that the acylation reaction of Lyso PC or GPC CdCl 2 with fatty acid bearing bulky aromatic group could be accomplished in 85% and 74% yield respectively by using a fatty acid/Lyso PC(or GPC CdCl 2) molar ratio of 4, DMAP/Lyso PC(or GPC CdCl 2) molar ratio of 4 and DCC/fatty acid molar ratio of 0 6 (1 for the acylation of GPC CdCl 2). The procedures described provide significant improvements in yield over methods repor ted .
