A well-known ternary plastic explosive,Czech Semtex 1H,contains a mixture of PETN and RDX softened by SBR.In this work,BCHMX was used to replace PETN in Semtex 1H to form Sem-BC+RDX.In addition,another mixture based o...A well-known ternary plastic explosive,Czech Semtex 1H,contains a mixture of PETN and RDX softened by SBR.In this work,BCHMX was used to replace PETN in Semtex 1H to form Sem-BC+RDX.In addition,another mixture based on BCHMX and HMX as energetic fillers bonded by the polymeric matrix of Semtex 1H(Sem-BC+HMX)was studied.The particle size distribution of each individual explosive was determined to obtain the optimum mixing conditions.Friction and impact sensitivities were determined.The velocity of detonation was reported practically and the detonation properties were calculated by EXPLO5 code.The explosive strength of each sample was measured by the ballistic mortar test.The conclusion confirms that the velocity of detonation of Sem-BC+HMX was the highest in comparison with the prepared samples.Sem-BC+RDX has the least impact and frictions sensitivities.Sem-BC+RDX has higher detonation velocity,detonation properties and explosive strength than Semtex 1H.Addition of BCHMX in Semtex 1H as a replacement for PETN is the candidate to produce a high performance advanced Czech plastic explosive.展开更多
Background: High levels of MCL-1 and BCL-2 proteins have been found in Chronic Lymphocytic Leukemia (CLL), and inversely correlated with response to treatment. BCL-2/Bax ratio is the main director of apoptosis in CLL....Background: High levels of MCL-1 and BCL-2 proteins have been found in Chronic Lymphocytic Leukemia (CLL), and inversely correlated with response to treatment. BCL-2/Bax ratio is the main director of apoptosis in CLL. The study aimed to clarify the prognostic role of MCL-1, BCL-2 and BCL-2/ Bax ratio in B-CLL. Patients & method: Estimation of MCL-1, BCL-2 and Bax expressions by a flow cytometry in 45 B-CLL patients and the prognostic value of these markers were correlated with other well-known established prognostic markers and treatment response. Results: MCL-1 was expressed in 60% of cases while BCL-2 was expressed in 82.2% of cases. MCL-1 expression was significantly high in male gender, short lymphocyte doubling time (LDT), and high expression of CD 38 (p β2M, CD38 expression), low ZAP-70 expression, splenomegaly and higher Rai stage were significantly increased in patients with high expression of BCL-2 (p β2M, high C-D38 expression, low ZAP-70 expression, the poor cytogenetic and splenomegaly in patients with high expression of BCL-2/ Bax ratio (p In conclusion: MCL-1, BCL-2 expressions and BCL-2/Bax ratio could be useful potential predictive and prognostic markers in B-CLL.展开更多
文摘A well-known ternary plastic explosive,Czech Semtex 1H,contains a mixture of PETN and RDX softened by SBR.In this work,BCHMX was used to replace PETN in Semtex 1H to form Sem-BC+RDX.In addition,another mixture based on BCHMX and HMX as energetic fillers bonded by the polymeric matrix of Semtex 1H(Sem-BC+HMX)was studied.The particle size distribution of each individual explosive was determined to obtain the optimum mixing conditions.Friction and impact sensitivities were determined.The velocity of detonation was reported practically and the detonation properties were calculated by EXPLO5 code.The explosive strength of each sample was measured by the ballistic mortar test.The conclusion confirms that the velocity of detonation of Sem-BC+HMX was the highest in comparison with the prepared samples.Sem-BC+RDX has the least impact and frictions sensitivities.Sem-BC+RDX has higher detonation velocity,detonation properties and explosive strength than Semtex 1H.Addition of BCHMX in Semtex 1H as a replacement for PETN is the candidate to produce a high performance advanced Czech plastic explosive.
文摘Background: High levels of MCL-1 and BCL-2 proteins have been found in Chronic Lymphocytic Leukemia (CLL), and inversely correlated with response to treatment. BCL-2/Bax ratio is the main director of apoptosis in CLL. The study aimed to clarify the prognostic role of MCL-1, BCL-2 and BCL-2/ Bax ratio in B-CLL. Patients & method: Estimation of MCL-1, BCL-2 and Bax expressions by a flow cytometry in 45 B-CLL patients and the prognostic value of these markers were correlated with other well-known established prognostic markers and treatment response. Results: MCL-1 was expressed in 60% of cases while BCL-2 was expressed in 82.2% of cases. MCL-1 expression was significantly high in male gender, short lymphocyte doubling time (LDT), and high expression of CD 38 (p β2M, CD38 expression), low ZAP-70 expression, splenomegaly and higher Rai stage were significantly increased in patients with high expression of BCL-2 (p β2M, high C-D38 expression, low ZAP-70 expression, the poor cytogenetic and splenomegaly in patients with high expression of BCL-2/ Bax ratio (p In conclusion: MCL-1, BCL-2 expressions and BCL-2/Bax ratio could be useful potential predictive and prognostic markers in B-CLL.
