The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal homeostasis.With the discovery of local RAS components in diverse organ...The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal homeostasis.With the discovery of local RAS components in diverse organs,including the brain,and related biologically active peptides.展开更多
Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose tissue.Visceral adipose tissue has deleterious effects on health because it secretes large amounts of inflammator...Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose tissue.Visceral adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory cytokines.Nutritional calorie restriction associated with strength training may be useful in managing chronic systemic inflammation.This study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary,overweight,and obese young men.This study included twelve men(Age:[34.95±9.77]years;Height:[174.16±3.66]centimeter[cm];Weight:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),who performed a single strength training session.The strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises,45°leg press,bench press,leg extension,machine row,leg curl,and shoulder press.Blood samples were collected before,immediately after,and 1-h subsequent after strength training.The plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h after the strength training session if compared to levels before the training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h[1-h subsequent][1523±798],6 pg/mL,p=0.0028).The plasma leptin levels did not differ at any time point.In conclusion,a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese individuals.This effect,at least in part,supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.展开更多
基金financial support from the Brazili an government funding agencies:FAPEMIG(Funda??o de AmparoàPesquisa do Estado de Minas Gerais,Brazil)CNPq(Conselho Nacional de Desenvoivimento Cientificoe Tecnologico,Brazil)+1 种基金CAPES(Coordena??o de Aperfei?oamento de Pessoal de Nivel Superior)ALT received financial support from UTHealth Department of Psychiatry and Behavioral Sciences,NIH/NIA,TARCC.ASM and ALT are CNPq fellowship recipients。
文摘The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal homeostasis.With the discovery of local RAS components in diverse organs,including the brain,and related biologically active peptides.
文摘Obesity has a complex multifactorial etiology and is characterized by excessive accumulation of adipose tissue.Visceral adipose tissue has deleterious effects on health because it secretes large amounts of inflammatory cytokines.Nutritional calorie restriction associated with strength training may be useful in managing chronic systemic inflammation.This study aimed to evaluate the acute effect of a single strength-training session on plasma adipokine levels in sedentary,overweight,and obese young men.This study included twelve men(Age:[34.95±9.77]years;Height:[174.16±3.66]centimeter[cm];Weight:[97.83±12.87]kilogram(kg);body mass index[BMI]:[32.30±4.51]kg/m2),who performed a single strength training session.The strength training protocol consisted of 4 sets of 12 repetitions in the following six exercises,45°leg press,bench press,leg extension,machine row,leg curl,and shoulder press.Blood samples were collected before,immediately after,and 1-h subsequent after strength training.The plasma levels of resistin and leptin were measured.A significant decrease in resistin levels were found 1 h after the strength training session if compared to levels before the training session(pre-[before][2390±1199]picograms per milliliter[pg/mL]vs post-1 h[1-h subsequent][1523±798],6 pg/mL,p=0.0028).The plasma leptin levels did not differ at any time point.In conclusion,a very well controlled single session of strength training significantly decreased the plasma levels of resistin without altering the concentration of leptin in overweight and obese individuals.This effect,at least in part,supports the benefits of exercise by reducing the low grade inflammation and insulin resistance in obesity.
