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Update on acute myeloid leukemia stem cells:New discoveries and therapeutic opportunities 被引量:3
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作者 maximilian Stahl Tae Kon Kim amer m zeidan 《World Journal of Stem Cells》 SCIE CAS 2016年第10期316-331,共16页
The existence of cancer stem cells has been wellestablished in acute myeloid leukemia. Initial proof of the existence of leukemia stem cells(LSCs) was accomplished by functional studies in xenograft models making use ... The existence of cancer stem cells has been wellestablished in acute myeloid leukemia. Initial proof of the existence of leukemia stem cells(LSCs) was accomplished by functional studies in xenograft models making use of the key features shared with normal hematopoietic stem cells(HSCs) such as the capacity of self-renewal and the ability to initiate and sustain growth of progenitors in vivo. Significant progress has also been made in identifying the phenotype and signaling pathways specific for LSCs. Therapeutically, a multitude of drugs targeting LSCs are in different phases of preclinical and clinical development. This review focuses on recent discoveries which have advanced our understanding of LSC biology and provided rational targets for development of novel therapeutic agents. One of the major challenges is how to target the selfrenewal pathways of LSCs without affecting normal HSCs significantly therefore providing an acceptable therapeutic window. Important issues pertinent to the successful design and conduct of clinical trials evaluating drugs targeting LSCs will be discussed as well. 展开更多
关键词 Leukemia stem cells Cancer stem cells Acute myeloid leukemia Stem cell niche XENOTRANSPLANTATION PLERIXAFOR NF-κ B C-X-C chemokine receptor type 4
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