Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20%of the global population(Grundy et al.,2019).Current pain therapies are poorly effec...Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20%of the global population(Grundy et al.,2019).Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects,hence the need to identify novel molecular and cellular targets for drug development.展开更多
The scope of the paper is the design of a fluid machinery with a multiphysics procedure, through CAD （computer-aided design）-CAE （computer-aided engineering）-CAx （computer-aided technologies） tools. The study of...The scope of the paper is the design of a fluid machinery with a multiphysics procedure, through CAD （computer-aided design）-CAE （computer-aided engineering）-CAx （computer-aided technologies） tools. The study of a wind turbine is a perfect example of a project that requires an interdisciplinary team design, in fact for such a project mechanical structure, and CFD （computational fluid dynamics） designers are necessary. In addition, in the last years, the multi domain design has been supported by the continuous development of software for computer-aided design and the unceasing increase of the connection between performances and computer costs： the final aim is to propose the instruments that assist the designer throughout all the steps of the project. The multi domain design, illustrated in this article, is based on how to design the wind turbine, and it is not about process management and manufacturability. In particular, in the article, the emphasis will be placed on the integration between CAD and mathematical software of general type and on the CAD-CAE integration.展开更多
基金supported by the co-funding European Union-Next Generation EU,in the context of The National Recovery and Resilience Plan,Investment 1.5 Ecosystems of Innovation,Project Tuscany Health Ecosystem(THE),CUP:B83C22003920001Italian Ministry of University and Research(MIUR)-Dipartimenti di Eccellenza 2023-2027 to the Department NEUROFARBA(to CG)。
文摘Abdominal pain is a common symptom associated with irritable bowel syndrome and inflammatory bowel diseases(IBDs),affecting about 20%of the global population(Grundy et al.,2019).Current pain therapies are poorly effective on visceral pain of intestinal origin and present several side effects,hence the need to identify novel molecular and cellular targets for drug development.
文摘The scope of the paper is the design of a fluid machinery with a multiphysics procedure, through CAD （computer-aided design）-CAE （computer-aided engineering）-CAx （computer-aided technologies） tools. The study of a wind turbine is a perfect example of a project that requires an interdisciplinary team design, in fact for such a project mechanical structure, and CFD （computational fluid dynamics） designers are necessary. In addition, in the last years, the multi domain design has been supported by the continuous development of software for computer-aided design and the unceasing increase of the connection between performances and computer costs： the final aim is to propose the instruments that assist the designer throughout all the steps of the project. The multi domain design, illustrated in this article, is based on how to design the wind turbine, and it is not about process management and manufacturability. In particular, in the article, the emphasis will be placed on the integration between CAD and mathematical software of general type and on the CAD-CAE integration.
