Vitamin D,selenium,and antidiabetic drugs in the treatment of type 2 diabetes mellitus with Hashimoto's thyroiditis

BACKGROUND Diabetes and thyroiditis are closely related.They occur in combination and cause significant damage to the body.There is no clear treatment for type-2 diabetes mellitus(T2DM)with Hashimoto's thyroiditis(HT).While single symptomatic drug treatment of the two diseases is less effective,combined drug treatment may improve efficacy.AIM To investigate the effect of a combination of vitamin D,selenium,and hypoglycemic agents in T2DM with HT.METHODS This retrospective study included 150 patients with T2DM and HT treated at The Central Hospital of Shaoyang from March 2020 to February 2023.Fifty patients were assigned to the control group,test group A,and test group B according to different treatment methods.The control group received low-iodine diet guidance and hypoglycemic drug treatment.Test group A received the control treatment plus vitamin D treatment.Test group B received the group A treatment plus selenium.Blood levels of markers of thyroid function[free T3(FT3),thyroid stimulating hormone(TSH),free T4(FT4)],autoantibodies[thyroid peroxidase antibody(TPOAB)and thyroid globulin antibody(TGAB)],blood lipid index[low-density lipoprotein cholesterol(LDL-C),total cholesterol(TC),triacylglycerol(TG)],blood glucose index[fasting blood glucose(FBG),and hemoglobin A1c(HbA1c)]were measured pre-treatment and 3 and 6 months after treatment.The relationships between serum 25-hydroxyvitamin D3[25(OH)D3]level and each of these indices were analyzed.RESULTS The levels of 25(OH)D3,FT3,FT4,and LDL-C increased in the order of the control group,test group A,and test group B(all P<0.05).The TPOAB,TGAB,TC,TG,FBG,HbA1c,and TSH levels increased in the order of test groups B,A,and the control group(all P<0.05).All the above indices were compared after 3 and 6 months of treatment.Pre-treatment,there was no divergence in serum 25(OH)D3 level,thyroid function-related indexes,autoantibodies level,blood glucose,and blood lipid index between the control group,test groups A and B(all P>0.05).The 25(OH)D3 levels in test groups A and B were negatively correlated with FT4 and TGAB(all P<0.05).CONCLUSION The combination drug treatment for T2DM with HT significantly improved thyroid function,autoantibody,and blood glucose and lipid levels.

ROS Balance Autoregulating Core-Shell CeO_(2)@ZIF-8/Au Nanoplatform for Wound Repair

Reactive oxygen species(ROS)plays important roles in living organisms.While ROS is a double-edged sword,which can eliminate drug-resistant bacteria,but excessive levels can cause oxidative damage to cells.A core–shell nanozyme,Ce O_(2)@ZIF-8/Au,has been crafted,spontaneously activating both ROS generating and scavenging functions,achieving the multifaceted functions of eliminating bacteria,reducing inflammation,and promoting wound healing.The Au Nanoparticles(NPs)on the shell exhibit high-efficiency peroxidase-like activity,producing ROS to kill bacteria.Meanwhile,the encapsulation of Ce O_(2) core within ZIF-8 provides a seal for temporarily limiting the superoxide dismutase and catalase-like activities of Ce O_(2) nanoparticles.Subsequently,as the ZIF-8 structure decomposes in the acidic microenvironment,the Ce O_(2) core is gradually released,exerting its ROS scavenging activity to eliminate excess ROS produced by the Au NPs.These two functions automatically and continuously regulate the balance of ROS levels,ultimately achieving the function of killing bacteria,reducing inflammation,and promoting wound healing.Such innovative ROS spontaneous regulators hold immense potential for revolutionizing the field of antibacterial agents and therapies.

Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis

Four new norditerpenoid heterodimers with different dimerization patterns-namely,trigofragiloids A-C(denoted as compounds 1-3)and(+)-and(-)-trigofragiloid D(compound 4)-and three new phenanthrenone norditerpenoids-namely,trigofragiloids E-G(compounds 5-7)-were isolated from Trigonostemon fragilis.Compounds 1 and 2 feature a novel heterodimeric carbon skeleton formed by the conjugation of a tetra-norditerpenoid and an ennea-norditerpenoid;they have been identified as class 2 atropisomers by means of quantum chemical calculations.Compound 3 is an unprecedented phenylpropanoid-norditerpenoid adduct with a new dimerization pattern.Compounds(+)-and(-)-4 are the first example of S-shaped 1,4-dioxane-fused norditerpenoid dimers.Inspired by the structure elucidation of compound 4,two co-occurring analogues,actephilol A and epiactephilol A,were structurally revised as a pair of geometrical isomers and were identified as two pairs of enantiomers,(+)-and(-)-8 and(+)-and(-)-9,respectively.Their structures were characterized using a combined method.Notably,compound 7 exhibits remarkable adenosine triphosphate-citrate lyase(ACLY)inhibition with a halfmaximal inhibition concentration(IC50)value of(0.46±0.11)lmol·L^(-1),as active as the positive control BMS-303141,and a molecular docking study offers deep insight into the interaction between compound 7 and ACLY.

SDH-FCOS:An Efficient Neural Network for Defect Detection in Urban Underground Pipelines

Urban underground pipelines are an important infrastructure in cities,and timely investigation of problems in underground pipelines can help ensure the normal operation of cities.Owing to the growing demand for defect detection in urban underground pipelines,this study developed an improved defect detection method for urban underground pipelines based on fully convolutional one-stage object detector(FCOS),called spatial pyramid pooling-fast(SPPF)feature fusion and dual detection heads based on FCOS(SDH-FCOS)model.This study improved the feature fusion component of the model network based on FCOS,introduced an SPPF network structure behind the last output feature layer of the backbone network,fused the local and global features,added a top-down path to accelerate the circulation of shallowinformation,and enriched the semantic information acquired by shallow features.The ability of the model to detect objects with multiple morphologies was strengthened by introducing dual detection heads.The experimental results using an open dataset of underground pipes show that the proposed SDH-FCOS model can recognize underground pipe defects more accurately;the average accuracy was improved by 2.7% compared with the original FCOS model,reducing the leakage rate to a large extent and achieving real-time detection.Also,our model achieved a good trade-off between accuracy and speed compared with other mainstream methods.This proved the effectiveness of the proposed model.

Structure,electric,and dielectric properties of(Sr_(0.7)Ca_(0.3))_(1.02)(Zr_(0.95−x)Ti_(0.05)Mn_(x))O_(3+δ)ceramics for BME-MLCCs application

Zirconate-based dielectric ceramics are potential materials for base metal electrode multilayer ceramic capacitors(BME-MLCCs)due to their exceptional chemical and thermal stability,as well as excellent dielectric properties.In this work,(Sr_(0.7)Ca_(0.3))1.02(Zr_(0.95−x)Ti_(0.05)Mn_(x))O_(3)+δ(SCZTM,0≤x≤0.05)ceramics with two coexisting phases were prepared using a solidstate reaction method in a reducing atmosphere.This study investigates the impact of Mn doping on sintering temperature,microstructure,and electrical properties of SCZTM ceramics.Mn doping can reduce the sintering temperature from 1450 to 1300℃.The impact of Mn doping on the structure and phonon vibration is minimal,resulting in a negligible effect on the intrinsic loss.The valence states of Mn ions and defects were characterized by X-ray photoelectron spectroscopy(XPS)and thermally stimulated depolarization current(TSDC)analysis.The results demonstrate the significant role of Mn doping in nonintrinsic loss.Due to the decrease in the concentration of oxygen vacancies(),SCZTM(x=0.01)ceramics exhibit attractive properties:resistivity(ρ)=8.93×10^(14)Ω·cm,dielectric constant(ε_(r))=36.16,dielectric loss(tanδ)=2.43×10^(–4),temperature dependence of dielectric constant(τ_(ε))=15.44 ppm/℃(@−55–200℃,1 MHz),Q×f=30,257 GHz(@6.12 GHz),and temperature coefficient of resonant frequency(τf)=–9.9 ppm/℃.SCZTM(x=0.01)ceramic powders were used to successfully fabricate Ni-based multilayer ceramic capacitors(MLCCs)with a high insulation resistance of IR≥39.6 TΩ,an ultralow dielectric loss of tanδ=0.2×10^(–4),and a wide operating temperature range(temperature coefficient of capacitance(T_(cc))=10.88 ppm/℃,@−55–200℃,1 MHz).SCZTM ceramics exhibit properties that make them suitable for use as BMEMLCC materials with potential market applications.

A Cautionary Note on the Application of GIS in Spatial Optimization Modeling

Spatial optimization as part of spatial modeling has been facilitated significantly by integration with GIS techniques. However, for certain research topics, applying standard GIS techniques may create problems which require attention. This paper serves as a cautionary note to demonstrate two problems associated with applying GIS in spatial optimization, using a capacitated p-median facility location optimization problem as an example. The first problem involves errors in interpolating spatial variations of travel costs from using kriging, a common set of techniques for raster files. The second problem is inaccuracy in routing performed on a graph directly created from polyline shapefiles, a common vector file type. While revealing these problems, the paper also suggests remedies. Specifically, interpolation errors can be eliminated by using agent-based spatial modeling while the inaccuracy in routing can be improved through altering the graph topology by splitting the long edges of the shapefile. These issues suggest the need for caution in applying GIS in spatial optimization study.

阿芬太尼联合瑞马唑仑用于纤维支气管镜检查深度镇静的半数有效量和95%有效量

目的计算阿芬太尼与瑞马唑仑用于纤维支气管镜检查深度镇静的半数有效量(ED_(50))和95%有效量(ED_(95))。方法选择拟行纤维支气管镜检查和治疗的患者50例。用试验剂量的阿芬太尼联合瑞马唑仑进行镇静,患者所给予的阿芬太尼剂量依序贯试验法设计,首位患者给予的阿芬太尼剂量为6.000μg/kg。待患者睫毛反射消失,改良警觉/镇静评分(MOAA/S)<1分后,进行纤维支气管镜检查或治疗,记录序贯试验的结果和不良反应发生情况。结果阿芬太尼剂量对数的回归方程为Y=8.9286X-7.6429,阿芬太尼的ED_(50)为7.286μg/kg(95%CI:6.566~8.084),ED_(95)为10.154μg/kg(95%CI:8.753~22.323)。结论阿芬太尼联合瑞马唑仑用于纤维支气管镜检查镇静的ED_(50)为7.286μg/kg,ED_(95)为10.154μg/kg。该镇静方案可以安全、有效地用于纤维支气管镜的检查和治疗中。

Effects of preparation parameters on growth and properties of β-Ga_(2)O_(3) film

The Ga_(2)O_(3) films are deposited on the Si and quartz substrates by magnetron sputtering, and annealing. The effects of preparation parameters(such as argon–oxygen flow ratio, sputtering power, sputtering time and annealing temperature)on the growth and properties(e.g., surface morphology, crystal structure, optical and electrical properties of the films) are studied by x-ray diffractometer(XRD), scanning electron microscope(SEM), and ultraviolet-visible spectrophotometer(UV-Vis). The results show that the thickness, crystallization quality and surface roughness of the β-Ga_(2)O_(3) film are influenced by those parameters. All β-Ga_(2)O_(3) films show good optical properties. Moreover, the value of bandgap increases with the enlarge of the percentage of oxygen increasing, and decreases with the increase of sputtering power and annealing temperature, indicating that the bandgap is related to the quality of the film and affected by the number of oxygen vacancy defects. The I–V curves show that the Ohmic behavior between metal and β-Ga_(2)O_(3) films is obtained at 900℃. Those results will be helpful for the further research of β-Ga_(2)O_(3) photoelectric semiconductor.

NH_(3)‑Induced In Situ Etching Strategy Derived 3D‑Interconnected Porous MXene/Carbon Dots Films for High Performance Flexible Supercapacitors

2D MXene(Ti_(3)CNT_(x))has been considered as the most promising electrode material for flexible supercapacitors owing to its metallic conductivity,ultra-high capacitance,and excellent flexibility.However,it suffers from a severe restacking problem during the electrode fabrication process,limiting the ion transport kinetics and the accessibility of ions in the electrodes,especially in the direction normal to the electrode surface.Herein,we report a NH_(3)-induced in situ etching strategy to fabricate 3D-interconnected porous MXene/carbon dots(p-MC)films for high-performance flexible supercapacitor.The pre-intercalated carbon dots(CDs)first prevent the restacking of MXene to expose more inner electrochemical active sites.The partially decomposed CDs generate NH_(3)for in situ etching of MXene nanosheets toward 3D-interconnected p-MC films.Benefiting from the structural merits and the 3D-interconnected ionic transmission channels,p-MC film electrodes achieve excellent gravimetric capacitance(688.9 F g^(-1)at 2 A g^(-1))and superior rate capability.Moreover,the optimized p-MC electrode is assembled into an asymmetric solid-state flexible supercapacitor with high energy density and superior cycling stability,demonstrating the great promise of p-MC electrode for practical applications.

Multimodal Sentiment Analysis Using BiGRU and Attention-Based Hybrid Fusion Strategy

Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimodal sentiment analysis is how to design an efficient multimodal feature fusion strategy.Unfortunately,existing work always considers feature-level fusion or decision-level fusion,and few research works focus on hybrid fusion strategies that contain feature-level fusion and decision-level fusion.To improve the performance of multimodal sentiment analysis,we present a novel multimodal sentiment analysis model using BiGRU and attention-based hybrid fusion strategy(BAHFS).Firstly,we apply BiGRU to learn the unimodal features of text,audio and video.Then we fuse the unimodal features into bimodal features using the bimodal attention fusion module.Next,BAHFS feeds the unimodal features and bimodal features into the trimodal attention fusion module and the trimodal concatenation fusion module simultaneously to get two sets of trimodal features.Finally,BAHFS makes a classification with the two sets of trimodal features respectively and gets the final analysis results with decision-level fusion.Based on the CMU-MOSI and CMU-MOSEI datasets,extensive experiments have been carried out to verify BAHFS’s superiority.

Dynamic behavior of outburst two-phase flow in a coal mine T-shaped roadway:The formation of impact airflow and its disaster-causing effect

The study of the dynamic disaster mechanism of coal and gas outburst two-phase flow is crucial for improving disaster reduction and rescue ability of coal mine outburst accidents.An outburst test in a T-shaped roadway was conducted using a self-developed large-scale outburst dynamic disaster test system.We investigated the release characteristics of main energy sources in coal seam,and obtained the dynamic characteristics of outburst two-phase flow in a roadway.Additionally,we established a formation model for outburst impact flow and a model for its flow in a bifurcated structure.The results indicate that the outburst process exhibits pulse characteristics,and the rapid destruction process of coal seam and the blocking state of gas flow are the main causes of the pulse phenomenon.The outburst energy is released in stages,and the elastic potential energy is released in the vertical direction before the horizontal direction.In a straight roadway,the impact force oscillates along the roadway.With an increase in the solid–gas ratio,the two-phase flow impact force gradually increases,and the disaster range extends from the middle of the roadway to the coal seam.In the area near the coal seam,the disaster caused by the two-phase flow impact is characterized by intermittent recovery.In a bifurcated roadway,the effect of impact airflow on impact dynamic disaster is much higher than that of two-phase flow,and the impact force tends to weaken with increasing solid-gas ratio.The impact force is asymmetrically distributed;it is higher on the left of the bifurcated roadway.With an increase in the solid-gas ratio,the static pressure rapidly decreases,and the bifurcated structure accelerates the attenuation of static pressure.Moreover,secondary acceleration is observed when the shock wave moves along the T-shaped roadway,indicating that the bifurcated structure increases the shock wave velocity.

Call for Papers:Special Section on Progress of Analysis Techniques for Domain-Specific Big Data

Since the concept of“Big Data”was first introduced in Nature in 2008,it has been widely applied in fields,such as business,healthcare,national defense,education,transportation,and security.With the maturity of artificial intelligence technology,big data analysis techniques tailored to various fields have made significant progress,but still face many challenges in terms of data quality,algorithms,and computing power.

Exploration on 5E Teaching Principle-based Education for the Object-oriented Software Construction Course

Most current object-oriented programming courses offered by domestic colleges and universities generally focus on the object-oriented programming language itself,i.e.,the programming grammar of the language,but ignore the design pattern.However,design patterns are essential to software engineering because they can solve common problems in software design and improve code reuse,readability,extensibility,and reliability.Our Object-oriented Software Construction Course is creative since it aims at cultivating students’object-oriented thinking as well as basic abilities required to construct high-quality,object-oriented software.Specifically,we exploit the 5E teaching principle during the education of this course,and present the whole pipeline in the paper.We also provide one case of the factory pattern to further demonstrate the implementation of the 5E teaching principle in the course.The effect of the 5E teaching principle has also been demonstrated.

Deep electrical structures of Qinzhou-Fangcheng Junction Zone in Guangxi and seismogenic environment of the 1936 Lingshan M6^(3/4)earthquake

The tectonic position of the southwest section of the Qinzhou Bay-Hangzhou Bay Tectonic Junction Zone(QHTJZ)can be determined by examining the Qinzhou-Fangcheng Junction Zone(QFJZ)in Guangxi.This zone is significant because it was the location of the largest earthquake ever recorded in the inland region of South China,specifically the 1936 Lingshan M6^(3/4)earthquake in Guangxi.Therefore,this region serves as an optimal location for researching the origins of intraplate earthquakes in South China.This study presents a display of a broadband magnetotelluric(MT)prospecting profile that traverses the Guangxi QFJZ and the Lingshan earthquake zone,extending from the northwest(NW)to the southeast(SE).A resistivity structure model was generated using three-dimensional(3D)inversion technology along the profile.The main faults in QFJZ were analyzed in terms of their deep extension forms and tectonic attributes.This analysis was performed by integrating the results obtained from geology,gravity,wave velocity ratio,Global Position System(GPS),and geothermal flow.The results showed that(1)the Dongzhong-Xiaodong fault(DXf),the eastern Fangcheng-Lingshan fault(FLf2),and the eastern Hepu-Beiliu fault(HBf2)were all trans-crustal deep faults,and crust-mantle ductile shear zones developed in the deep part.Two electrical boundary zones,DXf and HBf2,were identified.DXf inclined towards the northwest,while HBf2 inclined towards the southeast.The FangchengLingshan fault(FLf)exhibits a tectonic style resembling a“flower”shape in the upper crust.In the deeper section,it is characterized by an electrical boundary zone that gradually slopes towards the southeast direction.(2)The Hunan-Guangxi Passive Continental Margin(HGPCM)on the NW side of DXf had a stratified resistivity structure and relatively stable Bouguer gravity anomalies,which conformed to the quasi-craton tectonic attribute of the local failure at the southeastern margin of the Yangtze Block(YB).The southeastern side of this block is marked by the presence of the QFJZ and Yunkai Magmatic Arc(YKMA).These areas exhibit varying Bouguer gravity anomalies,indicating a combination of high and low resistivity in their electrical structures.This suggests that this zone has undergone multiple stages of structural evolution and transformation.The giant high-resistivity body under the Qinzhou-Fangcheng Remnant Ocean Basin(QFROB)might be the trace left by the extinction of the South China Ocean and the collision orogeny between YB and the Cathaysian Block(CB).The presence of sublow-resistivity layers in the middle-lower crust between the Liuwandashan Magmatic Arc(LMA)and YKMA indicates that this particular zone is being influenced from a distance by magmatic activities originating from the Leiqiong mantle.(3)The focal area of the 1936 Lingshan earthquake was located in the brittle high-resistivity body with a low strain rate.Under the coupling action of NWW-SEE regional tectonic stress and deep thermodynamic force,the brittle high-resistivity body in the upper crust became the main body for accumulating the tectonic stress.The Lingshan earthquake occurred due to the dextral strike-slip fracture instability of FLf2,a rock layer with slightly lower strength in the sub-high-resistivity zone.This instability was triggered when the accumulated stress reached the ultimate rock strength.The unveiling of the seismogenic model of the Lingshan earthquake,as presented in this study,holds significant scientific importance in comprehending the factors contributing to intraplate earthquakes in the South China region.

超声多普勒引导下痔动脉结扎术联合微创手术治疗重症痔疮的临床疗效观察

目的探究超声多普勒引导下痔动脉结扎术(DG-HAL)联合吻合器痔上黏膜环切术(PPH)治疗重症痔疮的临床疗效及安全性。方法选择2016年1月-2017年1月于该院就诊的重症痔疮患者72例,按照随机数字表法分为对照组(n=35)与观察组(n=37),对照组患者接受PPH治疗,观察组接受DGHAL联合PPH治疗。观察两组患者的手术相关指标、治疗效果及并发症发生率等。结果两组患者手术时间、术中出血量无明显差异(P>0.05)。观察组术后创面愈合时间及住院时间明显短于对照组,差异有统计学意义(P<0.05)。观察组术后1个月治疗有效率为94.6%,明显高于对照组有效率77.1%,差异有统计学意义(P<0.05)。两组患者术前和术后7 d视觉模拟评分(VAS)无明显差异(P>0.05)。观察组术后14 d VAS评分明显低于对照组(P<0.05)。观察组术后3个月Wexner评分明显低于对照组,差异有统计学意义(P<0.05)。观察组并发症发生率为2.7%,明显低于对照组(P<0.05)。结论DG-HAL联合PPH治疗重症痔疮有较好的临床疗效,手术操作简单安全,术后并发症发生率低,值得临床推广使用。

肠道菌群在肿瘤免疫治疗中的作用研究进展

肠道微生物与肿瘤发生、发展关系密切。机体暴露于大量肠道菌群及其代谢产物中,构成机体的生态环境,肠道微生物通过多种途径参与肿瘤的发生与发展。肠道菌群在肿瘤的治疗中发挥重要作用。目前,肿瘤免疫检测点抑制剂在多种恶性肿瘤中的治疗取得重要突破,肠道微生物组对肿瘤免疫治疗,尤其是免疫检测点抑制剂的疗效产生重要影响。本文就近年来肠道菌群对肿瘤免疫治疗中的作用及影响展开综述,为免疫检测点抑制剂在肿瘤治疗中的应用提供参考。

Effect of Practicing Calligraphy on the Development of Children's Emotional Intelligence

Introduction The relationship between practicing calligraphy and individual emotion is an important facet of ancient calligraphic theory.Ancient traditional Chinese medicine books contain records of emotional therapy.Chinese calligraphy can regulate emotions and cultivate children’s temperament and intelligence.

Overexpression of connective tissue growth factor WISP-1 in Chinese primary rectal cancer patients

AIM： To clarify the expression change of Wnt-induced secreted protein-1 （WISP-l） in human rectal cancer and to determine whether it is correlated with invasion and metastasis of human rectal cancer.METHODS： Eighty-six paired samples of rectal cancer and surgically resected distant normal rectal tissue were collected and allocated into cancer group and control group respectively. WISP-1 mRNA was detected by relative quantitative real-time RT-PCR and WISP-1 protein was examined by immunohistochemical staining.RESULTS： WISP-1 gene overexpression was found in 65% （56/86） primary rectal cancers, 2-30 times that of the level in normal matched rectal tissues （P = 0.001）. The mRNA expression level was correlated with Duke＇s staging, histological differentiation grade and lymph node status. The WISP-1 protein expression was in accordance with mRNA expression level. The positive degree of immunohistochemical staining in the cancer group （1.40±0.35） was different from that in control group （1.04± 0.08, P 〈 0.001）. Moreover, in cancer group the positive staining degree in high-level mRNA cancers （1.46 ±0.37, n = 56） was higher than that in low-level mRNA （1.28 ± 0.28, n = 30, P = 0.018）.CONCLUSION： Aberrant levels of WISP-1 expression may play a role in rectal tumorigenesis. WISP-1 may be used as a specific clinical diagnosis and prognosis marker in rectal cancer.

叶酸和维生素B_(12)缺乏患者的血常规及促红细胞生成素变化

目的评价铁蛋白(SF)正常而叶酸(FA)或(和)维生素B_(12)(VitB_(12))缺乏患者以及健康体检者的红细胞计数(RBC)、血红蛋白(HB)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血红蛋白浓度(MCHC)、红细胞体积分布宽度(RDW)及促红细胞生成素(EPO)检测结果的差异。方法收集118例门诊及住院患者的SF、FA、VitB_(12)、EPO和血常规结果,其中FA缺乏组34例,VitB_(12)缺乏组75例,FA和VitB_(12)缺乏组9例;另收集健康体检者113名作为对照组。结果叶酸缺乏组和对照组相比,HB、MCV、MCH降低,分别为[(122.82±28.93)g/L比(131.66±15.42)g/L,P<0.05]、[(84.50±8.14)fL比(87.94±4.93)fL,P<0.05]和[(28.15±3.32)pg比(29.67±1.88)pg,P<0.01];而RDW增加为[(14.62±3.11)比(13.47±1.74),P<0.05],差异有统计学意义。VitB_(12)缺乏组和对照组相比,RBC、HB和MCHC降低,分别为[(3.87±0.93)×10^(12)/L比(4.46±0.56)×10^(12)/L,P<0.01]、[(111.81±24.57)g/L比(131.66±15.42)g/L,P<0.01]和[(331.96±16.37)g/L比(337.48±11.29)g/L,P<0.01];而RDW增加,为[(14.60±3.48)比(13.47±1.74),P<0.01],差异有显著的统计学意义。VitB_(12)缺乏组和叶酸缺乏组相比,RBC和HB降低,分别为[(3.87±0.93)×10^(12)/L比(4.46±0.56)×10^(12)/L,P<0.01]和[(111.81±24.57)g/L比(131.66±15.42)g/L,P<0.05];而MCV和MCH增加,分别为[(88.25±9.20)fL比(84.50±8.14)fL,P<0.05]和[(29.34±3.75)pg比(28.15±3.32)pg,P<0.05],差异有统计学意义。结论仅以叶酸或(和)Vit B_(12)减少作为诊断巨幼细胞性贫血(MA)可能造成漏诊,VitB_(12)缺乏患者比叶酸缺乏患者贫血症状更重,VitB_(12)和叶酸均缺乏的患者RDW增大,EPO与叶酸或(和)Vit B_(12)缺乏无关。

The Mars rover subsurface penetrating radar onboard China's Mars 2020 mission

China's Mars probe,named Tianwen-1,including an orbiter and a landing rover,will be launched during the July-August 2020 Mars launch windows.Selected to be among the rover payloads is a Subsurface Penetrating Radar module(RoSPR).The main scientific objective of the RoSPR is to characterize the thickness and sub-layer distribution of the Martian soil.The RoSPR consists of two channels.The low frequency channel of the RoSPR will penetrate the Martian soil to depths of 10 to 100 m with a resolution of a few meters.The higher frequency channel will penetrate to a depth of 3 to 10 m with a resolution of a few centimeters.This paper describes the design of the instrument and some results of field experiments.