Effects of psychological intervention on negative emotions and psychological resilience in breast cancer patients after radical mastectomy

Breast cancer(BC)is the most common malignant tumor in women,and the treatment process not only results in physical pain but also significant psychological distress in patients.Psychological intervention(PI)has been recognized as an important approach in treating postoperative psychological disorders in BC patients.It has been proven that PI has a significant therapeutic effect on postoperative psychological disorders,improving patients'negative emotions,enhancing their psychological resilience,and effectively enhancing their quality of life and treatment compliance.

Maslinic Acid Suppresses High Glucose-induced Inflammation by Epigenetically Inhibiting TXNIP Expression

Objective Hyperglycemia-induced inflammation and subsequent endothelial injuries ultimately lead to the pathogenesis of cardiovascular diseases associated with high mortality,such as atherosclerosis.Maslinic acid(MA)is a phytochemical with anti-inflammatory activity.However,it remains unknown whether it can inhibit diabetes-associated cardiovascular inflammation.The present study aimed to determine the effect of MA on high glucose-induced endothelial inflammation and apoptosis in human umbilical vein endothelial cells(HUVECs)and to explore the underlying mechanism.Methods HUVECs were treated with high glucose to induce inflammation and apoptosis.Apoptosis was determined by flow cytometry.CCK-8 assay was used to examine cell viability.Production levels of cytokines were detected by quantitative realtime PCR(qPCR)and ELISA.Protein expression levels and signaling pathways activation were detected by Western blotting.RNA immunoprecipitation and qPCR were used to determine the N6-methyladenosine(m6A)levels of target mRNAs.Results MA promoted the recruitment of RNA demethylase ALKBH5 to TXNIP mRNA,and subsequently enhanced its m6A demethylation.By this means,MA decreased the stability of TXNIP mRNA and downregulated its expression level.Subsequently,reactive oxygen species(ROS)and production of pro-inflammatory cytokines,including TNF-α,IL-6 and IL-1β,were inhibited.And high glucose-induced apoptosis in HUVECs was inhibited by MA.Conclusion MA ameliorates high glucose-induced endothelial inflammation and injury,serving as a new potential therapeutic application for protecting against diabetes-associated atherosclerosis and other inflammatory diseases.

Research status of internet-delivered cognitive behavioral therapy in cancer patients

The latest global cancer burden data released by the International Agency for Research on Cancer of the World Health Organization in 2020 shows that there were 19.29 million new cancer cases worldwide,with 4.57 million in China,ranking first.The number of cancer survivors is increasing,with a 5-year survival rate exceeding 85%,but there are emotional disorders.Cognitive behavioral therapy(CBT)can improve negative emotions and has significant effects on patients.However,there is a limited number of physicians and high costs,so internet interventions have become a solution.The feasibility of web-based interventions for breast cancer patients has been proven.Research on internet-delivered CBT is also increasing.The purpose of this study was to review the concept of web-based CBT and its application status in cancer survivors,in order to provide relevant intervention for scholars and provide reference and supplement for patients to provide psychological therapy.