Outdoor Feeding Without Antibiotics,a Better Pattern for the Liver Health of Gushi Chicken

A 180 d feeding trial was conducted to evaluate the effect of different feeding modes on liver of Gushi chicken.The chickens from 1-day-old were fed in the warm house for 30 d,and then divided into four groups by different feeding modes(O-noant,outdoor without antibiotics;O-ant,outdoor with antibiotics;D-noant,indoor without antibiotics;D-ant,indoor with antibiotics),respectively,to evaluate the effect on liver.The results showed that different feeding modes significantly influenced the growth,liver weight,subcutaneous fat thickness,liver fat and liver free amino acid contents.The outdoor feeding without antibiotic reflected remarkably(P﹤0.05)low liver weight and fat content with normal morphology.While,other groups showed different levels of fat metabolism disorder in the liver.Based on chicken liver healthy,the outdoor feeding without antibiotic was the optimal feeding mode for Gushi chicken.

逻辑门控递药系统用于肿瘤免疫治疗前沿进展

免疫治疗已经逐渐成为癌症治疗的主流疗法之一。然而,由于肿瘤免疫抑制的生理环境,导致免疫细胞抗原的提取呈递能力较弱,细胞毒性T细胞的浸润激活不充分。并且,患者的个体差异和缺乏靶向的治疗分布会引发过度免疫激活或免疫抑制等不良反应,导致免疫疗法对实体瘤的治疗效果并不理想。近年来,有许多学者将聚合物、核酸、细胞等具有根据信号输入进行逻辑处理能力的单元设计成免疫疗法的平台,使治疗平台在靶向肿瘤部位后,根据多种来自肿瘤微环境或外界信号输入进行逻辑处理,来达到时空可控的治疗目的。本文简要概述了基于合成纳米载体、核酸和嵌合抗原受体T细胞设计的逻辑门控治疗平台和其在肿瘤免疫治疗中的研究进展,并对各类平台的优缺点进行了总结和展望。

Study on Effects of Curing Process on Characteristics of Marinated Beef Products

[Objectives]This study was conducted to compare the effects of different curing processes on the characteristics of marinated beef.[Methods]Marinated beef was obtained by two curing processes:static curing and injection and vacuum tumbling curing.The effects of the two curing processes on the production rate,curing absorption rate,water content,soluble protein content,amino acid nitrogen content,texture characteristics and microstructure of the product were compared.[Results]Compared with static curing,the production rate of marinated beef increased by 10%,the curing absorption rate increased by 28%,the texture and microstructure were improved,and the water content increased,while the soluble protein content decreased.As a result,the sensory score was higher.There was no significant difference in the content of amino acid nitrogen,but it decreased compared with raw meat.To sum up,injection and vacuum tumbling curing is more conducive to the processing of marinated beef.[Conclusions]This study provides a theoretical basis for the industrial production of marinated beef,and lays a foundation for in-depth exploration of injection and vacuum tumbling curing technique of marinated beef.

Teaching Status and Teaching Reform Ideas of Physical Chemistry Experiments for Food Quality and Safety Major

Physical chemistry experiments are an important branch of chemical experiments.In view of problems and shortcomings in physical chemistry experiment teaching of food quality and safety major in Chengdu University,the teaching methods of physical chemistry experiment course of food quality and safety major were explored and practiced,aiming to arouse students enthusiasm for experiments and cultivate their ability of independent learning,comprehensive thinking and independent problem solving.

Limited-Budget Consensus Design and Analysis for Multiagent Systems With Switching Topologies and Intermittent Communications

This paper investigates limited-budget consensus design and analysis problems of general high-order multiagent systems with intermittent communications and switching topologies.The main contribution of this paper is that the tradeoff design between the energy consumption and the consensus performance can be realized while achieving leaderless or leaderfollowing consensus,under constraints of limited budgets and intermittent communications.Firstly,a new intermittent limitedbudget consensus control protocol with a practical trade-off design index is proposed,where the total budget of the whole multiagent system is limited.Then,leaderless limited-budget consensus design and analysis criteria are derived,in which the matrix variables of linear matrix inequalities are determined according to the total budget and the practical trade-off design parameters.Meanwhile,an explicit formulation of the consensus function is derived to describe the consensus state trajectory of the whole system.Moreover,a new two-stage transformation strategy is utilized for leader-following cases,by which the dynamics decomposition of leaderless and leader-following cases can be converted into a unified framework,and sufficient conditions of the leader-following limited-budget consensus design and analysis are determined via those of the leaderless cases.Finally,numerical simulations are given to illustrate theoretical results.

Germinomas of the basal ganglia and thalamus: Four case reports

BACKGROUND The early diagnosis of basal ganglia and thalamus germinomas is often difficult due to the absence of elevated tumor markers,and atypical clinical symptoms and neuroimaging features.CASE SUMMARY Four male children aged 8 to 15 years were diagnosed with germinomas in the basal ganglia and thalamus by stereotactic biopsy from 2017 to 2019.All patients developed hemiplegia except patient 4 who also had cognitive decline,speech disturbance,nocturnal enuresis,polydipsia,polyuria,precocious puberty and abnormalities of thermoregulation.All four cases were alpha-fetoprotein and beta-human chorionic gonadotrophin(p-HCG)negative except patient 3 who had slightly elevated p-HCG in cerebrospinal fluid(CSF).No malignant cells were detected in the patients'CSF.Brain magnetic resonance imaging findings were diverse in these patients with the exception of the unique and common characteristics of ipsilateral hemisphere atrophy,especially in the cerebral peduncle.All patients were diagnosed with germinomas of the basal ganglia and thalamus by stereotactic brain biopsy.CONCLUSION Stereotactic brain biopsy is necessary to confirm the diagnosis of ectopic germinomas.Serial neuroimaging studies can not only differentiate disease but also determine the biopsy site.

Novel ternary metals-based telluride electrocatalyst with synergistic effects of high valence non-3d metal and oxophilic Te for pH-universal hydrogen evolution reaction

Electrocatalyst designs based on oxophilic foreign atoms are considered a promising approach for developing efficient pH-universal hydrogen evolution reaction(HER)electrocatalysts by overcoming the sluggish alkaline HER kinetics.Here,we design ternary transition metals-based nickel telluride(Mo WNi Te)catalysts consisting of high valence non-3d Mo and W metals and oxophilic Te as a first demonstration of non-precious heterogeneous electrocatalysts following the bifunctional mechanism.The Mo WNi Te showed excellent HER catalytic performance with overpotentials of 72,125,and 182 mV to reach the current densities of 10,100,and 1000 mA cm^(-2),respectively,and the corresponding Tafel slope of 47,52,and 58 mV dec-1in alkaline media,which is much superior to commercial Pt/C.Additionally,the HER performance of Mo WNi Te is well maintained up to 3000 h at the current density of 100 mA cm^(-2).It is further demonstrated that the Mo WNi Te exhibits remarkable HER activities with an overpotential of 45 mV(31 mV)and Tafel slope of 60 mV dec-1(34 mV dec-1)at 10 mA cm^(-2)in neutral(acid)media.The superior HER performance of Mo WNi Te is attributed to the electronic structure modulation,inducing highly active low valence states by the incorporation of high valence non-3d transition metals.It is also attributed to the oxophilic effect of Te,accelerating water dissociation kinetics through a bifunctional catalytic mechanism in alkaline media.Density functional theory calculations further reveal that such synergistic effects lead to reduced free energy for an efficient water dissociation process,resulting in remarkable HER catalytic performances within universal pH environments.

Synthesis and characterization of the flower-like La_(x)Ce_(1-x)O_(1.5+δ) catalyst for low-temperature oxidative coupling of methane

Lanthanum-based oxides are promising candidates for low-temperature oxidative coupling of methane(OCM).To further lower the OCM reaction temperature,the Ce doped flower-like La_(2)O_(2)CO_(3)microsphere catalysts were synthesized,achieving a significantly low reaction temperature (375℃) while maintaining high C_(2) hydrocarbon selectivity (43.0%).Doping Ce into the lattice of La_(2)O_(2)CO_(3)created more surface oxygen vacancies and bulk lattice defects,which was in favor of the transformation and migration of oxygen species at 350–400℃.The designed H_(2) temperature-programmed reduction (H_(2)-TPR) experiments provided strong evidence that the low reaction temperature of La_(x)Ce_(1-x)O_(1.5+δ)can be attributed to the transformation and migration of oxygen species,which dynamically generated surface oxygen vacancies for continuous oxygen activation to selectively convert methane.Moreover,designed temperatureprogrammed surface reaction (TPSR) clarified that two kinds of surface oxygen species in La_(x)Ce_(1-x)O_(1.5+δ)catalysts were concerned with catalytic performance,that is,the surface chemisorbed oxygen species for the activation of CH_(2)and the formation of CH_(2)·intermediates,surface La-Ce-O lattice oxygen species that caused the excessive oxidation of CH_(2)·intermediates.Finally,the factors affecting the transformation and migration of oxygen species were explored.

Fischer-Tropsch Synthesis over Alumina- Supported Cobalt-Based Catalysts: Effect of Support Variables

Different kinds of aluminum precursors were obtained from precipitating ammonium bicarbonate, ammonium carbonate, and saturated ammonium bicarbonate, then, boehmite (AlO(OH)), ammonium alumina carbonate hydroxide (AACH) and their mixture were obtained, and then, different kinds of alumina were obtained after calcination. Three catalysts supported on the different alumina were obtained via impregnating cobalt and ruthenium by incipient wetness. The effects of different precipitants on composition of precursors were?studied by XRD, FTIR, and TGA. The property and structure of alumina were studied by XRD and BET. The supported catalysts were studied by characterizations of XRD and H2-TPR, and the catalytic performance for Fischer-Tropsch synthesis (FTS) were evaluated at a fix-bed reactor. The relations among the composition of precursors, the property of alumina and the catalytic performance of supported catalysts were researched thoroughly.

Etching characteristics and surface modification of InGaSnO thin films under Cl_(2)/Ar plasma

Indium gallium tin oxide(IGTO)thin films have the potential for high mobility and lowtemperature processing,which makes them suitable for applications such as display backplanes and high-voltage switching devices.However,very few studies have investigated the plasmaetching characteristics of IGTO and changes in its properties after etching.In this study,the etching characteristics of IGTO were investigated using Cl_(2)/Ar plasma,and changes in surface properties were analyzed.Results showed that the etch rate increased with an increase in the proportion of Cl_(2),with the highest etch rate observed at 69 nm min^(-1)in pure Cl_(2)plasma with a gas flow rate of 100 sccm.Furthermore,increased radio-frequency power caused a rise in the etch rate,while a process pressure of 15 m Torr was optimal.The primary etching mechanism for IGTO thin films under Cl_(2)plasma was a chemical reaction,and an increased work function indicated the occurrence of defects on the surface.In addition,the etching process reduced the surface roughness of Cl_(2)-containing plasma,whereas the etching process in pure Ar plasma increased surface roughness.This study contributes to a better understanding of the plasmaetching characteristics of IGTO and changes in its properties after etching,providing valuable insights for IGTO-based applications.

Wideband radar cross section reduction based on absorptive coding metasurface with compound stealth mechanism

A scheme of combing wave absorption and phase cancellation mechanisms for widening radar cross section(RCS)reduction band is proposed.An absorptive coding metasurface implementing this scheme is derived from traditional circuit analog absorber(CAA)composed of resistive ring elements which characterize dual resonances behavior.It is constructed by replacing some of the CAA elements by another kind of resistive ring elements which is singly resonant in between the original two resonant bands and has reflection phase opposite to that of the original elements at resonance.Hence the developed metasurface achieves an improved low-RCS band over which the lower and higher sub-bands are mainly contributed by wave absorption mainly while the middle sub-band is formed by joint effect of wave absorption and antiphase cancellation mechanisms.The polarization-independent wideband RCS reduction property of the metasurface is validated by full-wave simulation results of a preliminary and an advanced design examples which employ the same element configuration but different element layout schemes as partitioned distribution and random coding.The advanced design also exhibits broadband bistatic low-RCS property and keeps a stable specular RCS reduction performance with regard to incident elevation angle up to 35◦.The advanced design is fabricated and the experimental results of the sample agrees qualitatively well with their simulated counterparts.The measured figure of merit(i.e.,low-RCS bandwidth ratio versus electrical thickness)of the sample is 40.572,which is superior to or comparable with those for most of other existing metasurface with compound RCS reduction mechanism.The proposed compound metasurface technique also features simple structure,light weight,low cost and easy fabrication compared with other techniques.This makes it promising in applications such as radar stealth and electromagnetic compatibility.

Suggestions on Curriculum Reform of Food Major in the Context of Educational Reform

The food major is an application-oriented major that involves a wide range of professional knowledge and disciplines,and provides applied talents with food production,inspection,and sales skills to the society.With the rapid development of society,the demand of social employers for talents also shows a diversified trend.For the cultivation of food professionals in the new era,it is necessary to improve their innovative spirit and practical ability,in order to adapt to the diverse development needs of society.Under the background of education reform,this paper briefly analyzed the teaching strategies of food major,and put forward specific reform suggestions,hoping to promote education reform to effectively promote the sustainable development of food major,and effectively improve the quality of education.

Analysis of Food Safety Supervision and Spot-Check in Sichuan Province in 2019

Through the analysis on 211614 batches of samples from 35 categories of food safety supervision and inspection in Sichuan Province by Administration for Market Regulation of Sichuan Province in 2019,four suggestions were finally put forward.The analysis results showed that in 2019,the overall trend of food safety in Sichuan Province was stable and improved.A total of 30 categories of unqualified samples were detected,and a total of 12135 batches of unqualified samples were detected,with an average sample unqualified rate of 5.73%.Among them,the main problems of unqualified samples were as follows:the use of food additives beyond the scope and limit,accounting for 40.17%of the total number of unqualified samples,microbial contamination in food,accounting for 23.61%of the total unqualified samples,the residue index of agricultural and veterinary drugs in food not meeting the standard,accounting for 15.61%of the total unqualified samples,the quality index in food not meeting the standard,accounting for 8.51%of the total number of unqualified samples,and heavy metals and other pollutants in food exceeding the standard,accounting for 7.10%of the total unqualified samples.

A study of the potential adverse effects of electrosurgical smoke on medical staff during malignant tumor surgery

Objective The aim of this study was to investigate the potential adverse effects of electrosurgical smoke on medical staff performing malignant tumor surgery.Methods This study was divided into two parts:in vitro and in vivo experiments.The human thyroid cancer cell line,ARO,was cultured and passaged.The tumor cells were burned with an ultrasonic scalpel,and the surgical smoke was absorbed by a transwell membrane.The captured particles were diluted in 3 mL of culture medium,and cell survival was assessed under a microscope.DNA was extracted from the cells for genotyping.BALB/c mice were used to construct thyroid cancer xenograft models.The tumor tissues were dissected on day 14 using an ultrasonic scalpel.The smoke from the electrosurgical procedure was collected on a transwell membrane.The membrane was washed in 2 mL of rinsing solution,and the solution was then injected into the right armpit of 10 mice.After sacrifice,the tumor tissues were removed and stained with hematoxylin and eosin(HE).Results Viable ARO cells could be seen on the first day after culturing cell fragments from surgical smoke,and vigorous cell proliferation could be seen on the 17th day of incubation.The genotype of the cells cultured in the presence of smoke particles was identical to the genotype of the original cells.Tumor growth was observed in four out of 10 mice injected with the smoke particle rinse.HE staining showed a significantly increased number of nuclei in the tumor tissue,which was consistent with the general morphological characteristics of malignant tumors.Conclusion Viable tumor cells were detected in surgical smoke generated by ultrasonic scalpel dissection,and these cells had growth activity.Thus,it is necessary to protect patients and medical staff from electrosurgical smoke.

Teaching Reform and Practice of Animal Products Processing under the Background of Intelligent Agriculture

Effective food professional personnel training strategies are explored and implemented,and interdisciplinary talents of food science and engineering in accordance with the background of intelligent agriculture are cultivated from the aspects of construction of teaching staff,reform of teaching content,upgrading of teaching model,construction of industry-education integration platform,which is of great significance to the modernization development of Chinese animal products processing industry.

Practical Exploration of Online Teaching of Animal Product Processing

Online teaching has become an important part of higher education due to the continuous effects of the global COVID-19. In this paper, the online teaching of Animal Product Processing was designed and implemented from three aspects of optimization of online teaching content, organization of teaching process and implementation of online assessment. According to the analysis of the questionnaire survey and the final evaluation results, the online teaching of Animal Product Processing is well received by the students and has achieved good teaching results, providing a useful reference for colleges and universities to carry out in-depth online teaching of Animal Product Processing.

Phase Behaviors of Multi-tailed B_(2)AB_(2)-Type Regio-isomeric Giant Surfactants at the Columnar-Spherical Boundary

We report herein the precision synthesis and phase behaviors of multi-tailed B_(2)AB_(2)-type regio-isomeric giant surfactants consisting of a hydrophilic polyhedral oligomeric silsesquioxane(POSS)head tethered with four hydrophobic polystyrene(PS)tails.The synthesis was accomplished through two sequential"click"reactions to give a series of regio-isomeric giant surfactants S2DS2(where S is short for PS tails and D for hydroxyl-functionalized POSS)in para-,meta-,and ortho-configurations.Their phase structures and phase be-haviors at the columnar-spherical boundary were investigated with a single PS tail molecular weight of 1.4 kDa.Specifically,the para-and meta-isomers show hexagonally packed cylinders phases with slightly different order-disorder transition temperatures(~120℃ and~130℃)and the ortho-isomer exhibits an order-order transition from a kinetically favored,metastable dodecagonal quasi-crystal phase to a thermodynamically stable sigma phase at~120℃,as well as a further transition into the disordered state at~140℃.The phase diagram was constructed and their differences were rationalized based on the calculated interfacial area per molecule.This work demonstrates that tiny structural disparity could not only lead to unconventional phase formation in single-component macro-molecules,but also render dynamic and rich phase behaviors in these macromolecular assemblies.

Stretching boundaries in neurophysiological monitoring

The most prevalent among nervous system tumors significantly jeopardize patient health.For nerve integrity preservation after tumor removal,continuous intraoperative neurophysiological monitoring(CINM)is indispensable during microsurgery.The paper highlights the articles about the development of a system that employs soft and stretchable organic electronic materials for CINM.This innovative system harnesses soft and stretchable organic electronic materials and deploys conductive polymer electrodes with low impedance and modulus.These electrodes facilitate uninterrupted near-field action potential recording during surgery,resulting in enhanced signal-to-noise ratios and reduced invasiveness.Additionally,the system's multiplexing capabilities enable precise nerve localization,even in the absence of anatomical landmarks.

Assessment of cheese sign and its association with vascular risk factors:Data from PUMCH dementia cohort

Background:In the clinic,practitioners encounter many patients with an abnormal pattern of dense punctate magnetic resonance imaging(MRI)signal in the basal ganglia,a phenomenon known as"cheese sign".This sign is reported as common in cerebrovascular diseases,dementia,and old age.Recently,cheese sign has been speculated to consist of dense perivascular space(PVS).This study aimed to assess the lesion types of cheese sign and analyze the correlation between this sign and vascular disease risk factors.Methods:A total of 812 patients from Peking Union Medical College Hospital(PUMCH)dementia cohort were enrolled.We analyzed the relationship between cheese sign and vascular risk.For assessing cheese sign and defining its degree,the abnormal punctate signals were classified into basal ganglia hyperintensity(BGH),PVS,lacunae/infarctions and microbleeds,and counted separately.Each type of lesion was rated on a four-level scale,and then the sum was calculated;this total was defined as the cheese sign score.Fazekas and Age-Related White Matter Changes(ARWMC)scores were used to evaluate the paraventricular,deep,and subcortical gray/white matter hyperintensities.Results:A total of 118 patients(14.5%)in this dementia cohort were found to have cheese sign.Age(odds ratio[OR]:1.090,95%confidence interval[CI]:1.064-1.120,P<0.001),hypertension(OR:1.828,95%CI:1.123-2.983,P=0.014),and stroke(OR:1.901,95%CI:1.092-3.259,P=0.025)were risk factors for cheese sign.There was no significant relationship between diabetes,hyperlipidemia,and cheese sign.The main components of cheese sign were BGH,PVS,and lacunae/infarction.The proportion of PVS increased with cheese sign severity.Conclusions:The risk factors for cheese sign were hypertension,age,and stroke.Cheese sign consists of BGH,PVS,and lacunae/infarction.

An Approximation Algorithm for the Parallel-Machine Customer Order Scheduling with Delivery Time and Submodular Rejection Penalties

In this paper,we consider the parallel-machine customer order scheduling with delivery time and submodular rejection penalties.In this problem,we are given m dedicated machines in parallel and n customer orders.Each order has a delivery time and consists of m product types and each product type should be manufactured on a dedicated machine.An order is either rejected,in which case a rejection penalty has to be paid,or accepted and manufactured on the m dedicated machines.The objective is to find a solution to minimize the sum of the maximum delivery completion time of the accepted orders and the penalty of the rejected orders which is determined by a submodular function.We design an LP rounding algorithm with approximation ratio of n+1 for this problem.