Ascending aorta dilatation reduces the influence of elevated pulse pressure on left ventricular hypertrophy:findings from a Chinese elderly hypertensive population

OBJECTIVE To determine the role of ascending aorta dilatation in the relationship between pulse pressure(PP)and left ventricular(LV)hypertrophy.METHODS A total of 1556 Chinese elderly hypertensive patients were retrospectively studied.Transthoracic echocardiography was used to obtain the aortic and cardiac structure measurements.In addition,brachial blood pressure was measured,and total arterial compliance,systemic vascular resistance,arterial elastance,and end-systolic LV elastance were calculated.The participants were divided into four groups according to the status of ascending aortic diameter and PP.RESULTS LV mass index increased in succession in the four groups,i.e.,the group with the normal aorta and lower PP,with the normal aorta and higher PP,with aortic dilatation and lower PP,and with aortic dilatation and higher PP(Ptrend<0.001).Total arterial compliance−1,arterial elastance,and end-systolic LV elastance were slightly higher in the individuals with normal aorta compared to those with aortic dilatation,regardless of PP being lower or higher(P<0.01).Compared to the group with the normal aorta and lower PP,individuals with aortic dilatation had a significantly increased multivariable adjusted risk of LV hypertrophy,and higher PP further exacerbated this risk[aortic dilatation with lower PP(OR=1.75,95%CI:1.01–3.04)and aortic dilatation with higher PP(OR=3.42,95%CI:2.03–5.77)].In the relation between PP and LV mass index(β=0.095,P<0.001),-41.3%of the total effect was attributable to mediation by ascending aortic diameter(P<0.0001).CONCLUSIONS In Chinese elderly patients with hypertension,ascending aorta dilatation could reduce the influence of elevated PP on LV hypertrophy.

Improved electrochemical performance of Li(Ni0.6Co0.2Mn0.2)O2 at high charging cut-off voltage with Li1.4Al0.4Ti1.6（PO4）3 surface coating

Ba0.8Sr0.2FeO3-δhas been surface-modified by the lithium-ion conductor Li1.4Al0.4Ti1.6(PO4)3via a facile mechanical fusion method. The annealing temperature during coating process shows a strong impact on the surface morphology and chemical composition of Li(Ni0.6 Co0.2 Mn0.2)O2. The 600-?C annealed material exhibits the best cyclic stability at high charging cut-off voltage of 4.5 V(versus Li+/Li) with the capacity retention of 90.9% after 100 cycles, which is much higher than that of bare material(79%). Moreover, the rate capability and thermal stability are also improved by Li1.4Al0.4Ti1.6(PO4)3coating. The enhanced performance can be attributed to the improved stability of interface between Ba0.8Sr0.2FeO3-δand electrolyte by Li1.4Al0.4Ti1.6(PO4)3modification. The results of this work provide a possible method to design reliable cathode materials to achieve high energy density and long cycle life.