目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关...目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关键词等进行可视化分析。结果:(1)Web of Science数据库共纳入946篇文献,发文量总体呈上升趋势。发文量最多的国家、机构和作者依次为:美国、哈佛大学和Fregni Felipe教授,热点关键词是运动皮质、恢复、康复、瘫痪手等。近2年突现词有系统综述、吞咽功能、障碍、模型等。(2)中国知网数据库共纳入392篇文献,发文量最多的机构和作者依次为:首都医科大学宣武医院康复医学科和宋为群作者,热点关键词是失语、上肢功能、吞咽障碍和运动功能等,近2年的突现词为非侵入性脑刺激、上肢功能和脑电图等。结论:tDCS治疗脑卒中的中文文献总体发文量不高,发文机构分布不平衡且缺乏合作,今后应加强不同地区、不同机构间的合作,开展多中心、跨区域研究,应进行更深层次的作用机制研究。展开更多
It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental...It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and Si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the multi-mineral systems and the quality of geochemical modeling prediction of CO_(2) removal and storage efficacy in the basalt systems.展开更多
Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation.However,when this disordered pro...Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation.However,when this disordered proliferation continues,it induces the ISC to enter a cancerous state.The gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained basis.Micro-biota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors,while in steady state,differentiated colono-cytes are able to break down such metabolites,thereby protecting stem cells at the gut crypt.In the future,the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.展开更多
文摘目的:调查了解近10年国内外经颅直流电刺激治疗脑卒中领域相关研究现状、热点及趋势。方法:检索中国知网和Web of Science数据库中2013~2022年关于经颅直流电刺激治疗脑卒中的相关文献,用CiteSpace软件对文献的国家、机构、作者以及关键词等进行可视化分析。结果:(1)Web of Science数据库共纳入946篇文献,发文量总体呈上升趋势。发文量最多的国家、机构和作者依次为:美国、哈佛大学和Fregni Felipe教授,热点关键词是运动皮质、恢复、康复、瘫痪手等。近2年突现词有系统综述、吞咽功能、障碍、模型等。(2)中国知网数据库共纳入392篇文献,发文量最多的机构和作者依次为:首都医科大学宣武医院康复医学科和宋为群作者,热点关键词是失语、上肢功能、吞咽障碍和运动功能等,近2年的突现词为非侵入性脑刺激、上肢功能和脑电图等。结论:tDCS治疗脑卒中的中文文献总体发文量不高,发文机构分布不平衡且缺乏合作,今后应加强不同地区、不同机构间的合作,开展多中心、跨区域研究,应进行更深层次的作用机制研究。
基金partially supported by U.S. National Science Foundation grants EAR-2221907partly sponsored by agencies of the United States Government。
文摘It is a challenge to make thorough but efficient experimental designs for the coupled mineral dissolution and precipitation studies in a multi-mineral system, because it is difficult to speculate the best experimental duration, optimal sampling schedule, effects of different experimental conditions, and how to maximize the experimental outputs prior to the actual experiments. Geochemical modeling is an efficient and effective tool to assist the experimental design by virtually running all scenarios of interest for the studied system and predicting the experimental outcomes. Here we demonstrated an example of geochemical modeling assisted experimental design of coupled labradorite dissolution and calcite and clayey mineral precipitation using multiple isotope tracers. In this study, labradorite(plagioclase) was chosen as the reactant because it is both a major component and one of the most reactive minerals in basalt. Following our isotope doping studies of single minerals in the last ten years, initial solutions in the simulations were doped withmultiple isotopes(e.g., Ca and Si). Geochemical modeling results show that the use of isotope tracers gives us orders of magnitude more sensitivity than the conventional method based on concentrations and allows us to decouple dissolution and precipitation reactions at near-equilibrium condition. The simulations suggest that the precise unidirectional dissolution rates can inform us which rate laws plagioclase dissolution has followed. Calcite precipitation occurred at near-equilibrium and the multiple isotope tracer experiments would provide near-equilibrium precipitation rates, which was a challenge for the conventional concentration-based experiments. In addition, whether the precipitation of clayey phases is the rate-limiting step in some multi-mineral systems will be revealed. Overall, the modeling results of multimineral reaction kinetics will improve the understanding of the coupled dissolution–precipitation in the multi-mineral systems and the quality of geochemical modeling prediction of CO_(2) removal and storage efficacy in the basalt systems.
基金Supported by Scientific Research Fund Project of Education Department of Yunnan Province,No.2023J0346the Kunming Health Commission Kunming Health Science and Technology Personnel Training Project,No.2021-SW-75the Medical and Health Science and Technology Project of Kunming Health Committee,No.2022-03-09-008.
文摘Proliferation and differentiation of intestinal stem cell(ISC)to replace damaged gut mucosal epithelial cells in inflammatory states is a critical step in ameliorating gut inflammation.However,when this disordered proliferation continues,it induces the ISC to enter a cancerous state.The gut microbiota on the free surface of the gut mucosal barrier is able to interact with ISC on a sustained basis.Micro-biota metabolites are able to regulate the proliferation of gut stem and progenitor cells through transcription factors,while in steady state,differentiated colono-cytes are able to break down such metabolites,thereby protecting stem cells at the gut crypt.In the future,the gut flora and its metabolites mediating the regulation of ISC differentiation will be a potential treatment for enteropathies.
