Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery

BACKGROUND The albumin-bilirubin(ALBI)score is a serum biochemical indicator of liver function and has been proven to have prognostic value in a variety of cancers.In colorectal cancer(CRC),a high ALBI score tends to be associated with poorer survival.AIM To investigate the correlation between the preoperative ALBI score and outcomes in CRC patients who underwent radical surgery.METHODS Patients who underwent radical CRC surgery between January 2011 and January 2020 at a single clinical center were included.The ALBI score was calculated by the formula(log10 bilirubin×0.66)+(albumin×-0.085),and the cutoff value for grouping patients was-2.8.The short-term outcomes,overall survival(OS),and disease-free survival(DFS)were calculated.RESULTS A total of 4025 CRC patients who underwent radical surgery were enrolled in this study,and there were 1908 patients in the low ALBI group and 2117 patients in the high ALBI group.Cox regression analysis revealed that age,tumor size,tumor stage,ALBI score,and overall complications were independent risk factors for OS;age,tumor stage,ALBI score,and overall complications were identified as independent risk factors for DFS.CONCLUSION A high preoperative ALBI score is correlated with adverse short-term outcomes,and the ALBI score is an independent risk factor for OS and DFS in patients with CRC undergoing radical surgery.

Prognostic prediction model of colorectal cancer based on preoperative serum tumor markers

BACKGROUND Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer(CRC),but also have been found to have potential prognostic value.AIM To analyze whether preoperative serum tumor markers,including carcinoembryonic antigen(CEA)and carbohydrate antigen 19-9(CA19-9),affect the prognosis of CRC.METHODS This was a retrospective study conducted in a single center.Patients with nonmetastatic CRC who underwent initial surgery between January 2011 and January 2020 were enrolled and divided into development site and validation site groups at a ratio of 7:3.The independent prognostic factors were screened by Cox regression analysis,and finally,a prognostic nomogram model was established.The newly developed model was tested by internal validation.RESULTS Eventually,3526 postoperative patients with nonmetastatic CRC were included in the study.There were 2473 patients at the development site and 1056 patients at the validation site.Age(P<0.01,HR=1.042,95%CI=1.033-1.051),tumor node metastasis(TNM)classification(P<0.01,HR=1.938,95%CI=1.665-2.255),preoperative CEA(P=0.001,HR=1.393,95%CI=1.137-1.707)and CA19-9(P<0.01,HR=1.948,95%CI=1.614-2.438)levels were considered independent prognostic factors for patients with nonmetastatic CRC and were used as variables in the nomogram model.The areas under the curve of the development and validation sites were 0.655 and 0.658,respectively.The calibration plot also showed the significant performance of the newly established nomogram.CONCLUSION We successfully constructed a nomogram model based on age,TNM stage,preoperative CEA,and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.

沙芥叶总黄酮的体外抗氧化研究

本文以沙芥叶片为原料,提取沙芥叶片总黄酮。从沙芥叶总黄酮的粗提物与纯化物对羟自由基(?OH?)、超氧阴离子(O2-)和DPPH自由基的清除能力和对Fe3+的还原能力,比较系统的剖析了沙芥叶总黄酮的抗氧化能力。实验表明沙芥叶片总黄酮在化学本质上具有一定的抗氧化能力,整体抗氧化能力大小顺序为:纯化物>BHT >粗提物。

Loss Analysis of Magnetic Gear with Slotted in Magnetic Modulation Ring

In order to improve the operation efficiency of coaxial magnetic gear(CMG),in this paper,a CMG model with slotted in magnetic modulation ring is proposed.In this model,the permanent magnets(PMs)of internal and external rotors are distributed in Halbach array,the inner rotor PMs are equally divided into 3 small pieces,and the outer rotor PMs are equally divided into 2 small pieces.At the same time,the static magnetic modulation ring iron blocks are slotted,each iron block has 3 slots,the width of the slot is 0.4°,and the depth of the single side slot is 1mm.Finally,a two-dimensional model is established,and the eddy current loss and iron loss of the model are optimized,compared with the conventional CMG model,it is found that the changed pattern can increase the internal and external output torque by 4%and 4.12%,respectively.The eddy current loss is reduced by 66.57%,and the iron loss is reduced by 8.9%,which significantly improve the operation efficiency of the CMG.

A Novel High Performance Magnetic Gear with Auxiliary Silicon Steel Sheet

Magnetic gear is a transmission device with novel structure.It uses the principle of magnetic field modulation to transmit torque.In view of the magnetic leakage of the magnetic gear in the process of rotation and cannot be eliminated,a magnetic gear model with auxiliary silicon steel sheet is proposed.Based on the conventional magnetic gear structure,the silicon steel sheet is placed outside the permanent magnet of the outer rotor.The magnetization mode of the outer rotor permanent magnet is tangential magnetization,and the spoke structure is adopted,and the inner rotor PMs is surface mounted and magnetized in the radial magnetization.The improved model is simulated by finite element method under three-dimensional conditions,and the electromagnetic performances of the model are optimized.Compared with the conventional magnetic gear model,the improved model has good performance,which improves the transmission capacity of output torque and reduces torque ripple.It is a great significance to improve the performance of magnetic gear.