Breast cancer originates primarily from the epithelial cells of the mammary gland.Repeated mammary gland expansion and degeneration are accompanied by an increased risk of genetic alterations in the breast1.These muta...Breast cancer originates primarily from the epithelial cells of the mammary gland.Repeated mammary gland expansion and degeneration are accompanied by an increased risk of genetic alterations in the breast1.These mutations in breast epithelial cells dynamically occur in response to pregnancy,labor and delivery,breastfeeding,and the menstrual cycle,with a decline in mutation rates after menopause,which may be related to a decrease in estrogen levels.The breast epithelial cell mutations are also consistent with epidemiologic observations2.展开更多
基金supported by the National Natural Science Foundation of China (Grant No.32171363)the Fujian Major Scientific and Technological Special Project for Social Development (Grant No.2020YZ016002)+2 种基金the Science and Technology Project of Xiamen Municipal Bureau of Science and Technology (Grant No.3502Z20199047)the Xiamen’s Key Laboratory of Precision Medicine for Endocrine-Related Cancers (Grant No.XKLEC 2020KF02)the Fujian Key Laboratory of Precision Diagnosis and Treatment in Breast Cancer。
文摘Breast cancer originates primarily from the epithelial cells of the mammary gland.Repeated mammary gland expansion and degeneration are accompanied by an increased risk of genetic alterations in the breast1.These mutations in breast epithelial cells dynamically occur in response to pregnancy,labor and delivery,breastfeeding,and the menstrual cycle,with a decline in mutation rates after menopause,which may be related to a decrease in estrogen levels.The breast epithelial cell mutations are also consistent with epidemiologic observations2.
