Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretat...Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.展开更多
Two new rearranged diterpenoids, tomocinol C （1） and spirocaesalmin C （2） were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated based on comprehensive analysis of spectroscopic data,...Two new rearranged diterpenoids, tomocinol C （1） and spirocaesalmin C （2） were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated based on comprehensive analysis of spectroscopic data, and their absolute configurations were established by single crystal X-ray crystallography.展开更多
Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of...Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of the new compounds were established by extensive analysis of 1Dand 2DNMR spectra,as well as MS data.Their absolute configurations were determined by CD spectra.All compounds showed moderate inhibitory effects on A431,A549,BGC-823,HL-60,HT-29,and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 μM.展开更多
Two new phenanthrenoid dimers, named dijuncuenins A （1） and B （2）, were isolated from the ethanolic extract of the whole plant of Juncus effusus. Their structures were determined by 1D and 2D NMR spectroscopic ana...Two new phenanthrenoid dimers, named dijuncuenins A （1） and B （2）, were isolated from the ethanolic extract of the whole plant of Juncus effusus. Their structures were determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry. The plausible biosynthetic pathways of compounds 1 and 2 were proposed.展开更多
Two new dimeric diterpenes, birhodomolleins D （1） and E （2）, were characterized from the fruits of Rhododendron pumilum. Their structures featured two grayanane diterpenes dimerized through an oxygen bridge locati...Two new dimeric diterpenes, birhodomolleins D （1） and E （2）, were characterized from the fruits of Rhododendron pumilum. Their structures featured two grayanane diterpenes dimerized through an oxygen bridge locating at C-3 and C-2＇. They are the first examples of dimeric grayanane diterpenes with a 3-O-2＇ linkage from the Ericaceae family. Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data.展开更多
基金financial support of the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09301001-001,2015ZX09103002)the National Natural Science Fundation of China(Nos.81302657,81473112,81573305)
文摘Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.
基金financial support of the National Science & Technology Major Project ‘‘Key New Drug Creation and Manufacturing Program’’ (No.2012ZX09301001-001)the National Natural Science Funds (No.81302657,81473112,81573305)+1 种基金the Chinese Academy of Sciences (No.KSZD-EW-Z-004-01)the Shanghai Commission of Science and Technology (No.12JC1410300)
文摘Two new rearranged diterpenoids, tomocinol C （1） and spirocaesalmin C （2） were isolated from the seeds of Caesalpinia sappan. Their structures were elucidated based on comprehensive analysis of spectroscopic data, and their absolute configurations were established by single crystal X-ray crystallography.
基金Financial support from the National Science and Technology Major Project"Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09301001-001,2015ZX09103002)the National Natural Science Funds of China(Nos.81302657,81573305,81473112)+3 种基金Youth Innovation Promotion Association CAS,the Ministry of Science and Technology(No.2010DFA30980)the Chinese Academy of Sciences(No.KSZD-EW-Z-004-01)the Shanghai Commission of Science and Technology(No.11DZ1970700,12JC1410300)the Research Fund of University of Macao(MYRG2014-00020-ICMS-QRCM and MYRG2015-00153ICMS-QRCM)
文摘Phytochemical investigation on the whole plant of Inula cappa led to the isolation of two new germacrane-type sesquiterpene lactones,ineupatolides D and E（1 and 2）,together with three known analogs.The structures of the new compounds were established by extensive analysis of 1Dand 2DNMR spectra,as well as MS data.Their absolute configurations were determined by CD spectra.All compounds showed moderate inhibitory effects on A431,A549,BGC-823,HL-60,HT-29,and MCF-7 cancer cell lines with IC50 values ranging from 2.1 to 36.3 μM.
基金the financial support of the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"(No.2012ZX09301001-001)the National Natural Science Foundation of China(Nos.81302657,81473112,81573305)+1 种基金Youth Innovation Promotion Association CAS and for grants from the Chinese Academy of Sciences(No.KSZD-EW-Z-004-01)the State Key Laboratory of Drug Research(No.SIMM1501ZZ-03)
文摘Two new phenanthrenoid dimers, named dijuncuenins A （1） and B （2）, were isolated from the ethanolic extract of the whole plant of Juncus effusus. Their structures were determined by 1D and 2D NMR spectroscopic analysis and mass spectrometry. The plausible biosynthetic pathways of compounds 1 and 2 were proposed.
基金the financial support of the National Science & Technology Major Project“Key New Drug Creation and Manufacturing Program”(No.2015ZX09103002)the National Natural Science Fundation of China(No.81673327)the grants from the Key Laboratory of Drug Research, Shanghai Institute of Materia Medica(No. SIMM1501ZZ-03)
文摘Two new dimeric diterpenes, birhodomolleins D （1） and E （2）, were characterized from the fruits of Rhododendron pumilum. Their structures featured two grayanane diterpenes dimerized through an oxygen bridge locating at C-3 and C-2＇. They are the first examples of dimeric grayanane diterpenes with a 3-O-2＇ linkage from the Ericaceae family. Their structures were elucidated on the basis of comprehensive analysis of spectroscopic data.
