A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia

Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population.

Practice Instruction of Innovative and Entrepreneurial Training Program for Aquatic Animal Medicine Students

As an important platform for the combination of theory and practice,college students' innovative and entrepreneurial training program has an important impact on improving the comprehensive ability of undergraduates. The major of aquatic animal medicine is a new sea-related major. The continuous development and transformation and upgrading of aquaculture in the new period have put forward newer and higher requirements for the innovative and practical ability and comprehensive quality of aquatic animal medicine graduates. Taking the innovation and entrepreneurship program of college students majoring in aquatic animal medicine as an example,this paper analyzes the significance of the innovation training program for college students,the cultivation of students' scientific research ability,and the problems existing in the application and operation of the program,in order to provide a reference for the innovative education and talent training for students majoring in aquatic animal medicine.

SolidEarth： a new Digital Earth system for the modeling and visualization of the whole Earth space

Although many of the first-generation Digital Earth systems have proven to be quite useful for the modeling and visualization of geospatial objects relevant to the Earth＇s surface and near-surface, they were not designed for the purpose of modeling and application in geological or atmospheric space. There is a pressing need for a new Digital Earth system that can process geospatial information with full dimensionality. In this paper, we present a new Digital Earth system, termed SolidEarth, as an alternative virtual globe for the modeling and visualization of the whole Earth space including its surface, interior, and exterior space. SolidEarth consists of four functional components： modeling in geographical space, modeling in geological space, modeling in atmo- spheric space, and, integrated visualization and analysis. SolidEarth has a comprehensive treatment to the third spatial dimension and a series of sophisticated 3D spatial analysis functions. Therefore, it is well-suited to the volumetric representation and visual analysis of the inner/ outer spheres in Earth space. SolidEarth can be used in a number of fields such as geoscience research and education, the construction of Digital Earth applications, and other professional practices of Earth science.

Identification of potential interdisciplinary cooperative topics based on co-word network:Taking LIS and computer science as an example

[Purpose/significance]Interdisciplinary knowledge fusion plays a key role in promoting the development of interdisciplinary integration and providing new ideas for interdisciplinary cooperative research.This study sets out to identify potential interdisciplinary cooperative topics between Library and Information Science(LIS)and Computer Science.[Method/Process]We built an interdisciplinary co-word network to identify potential interdisciplinary cooperative topics by closed and opened irrelevant knowledge discovery methods.We also constructed the topic interdisciplinary cooperation potential index(TICPI)to calculate the interdisciplinary cooperation potential of the topic and found the best contact path of the cooperation topic by constructing the practicable value(PV)of the contact patch.[Result/Conclusion]The experimental data suggested that both methods can identify the same potential interdisciplinary cooperative topics,such as knowledge service&matrix decomposition,online comments&social media processing,academic text&generative adversarial network,network public opinion&smart home.Exploiting the cooperation potential of these topics can help the knowledge fusion between disciplines.

Research on identification of potential knowledge growth points in information science

The scientific system’s complexity makes it impossible to solve social problems by a single discipline independently,and interdisciplinary knowledge cooperation and innovation become an indispensable research mode of modern science.Identifying the potential interdisciplinary knowledge association is the key to promoting interdisciplinary cooperation.In this paper,based on analyzing the growth points of science,"knowledge growth point"is defined as the growth point of science that produces new knowledge,and its fundamental attributes and evaluation indexes have been analyzed.In contrast,the"interdisciplinary knowledge growth point"is defined as the introduction of related interdisciplinary concepts,theories,techniques,and methods,to conduct integrated research of key knowledge points of active disciplines,to generate growth point of innovative knowledge,and analyze its related research status.The identification of"potential interdisciplinary knowledge growth points"is helpful to promote knowledge innovation.Therefore,it is intended to analyze the identification methods of the generation of key knowledge nodes of the element of disciplines and interdisciplinary related knowledge,and explore quantitative and qualitative consultation to identify potential interdisciplinary knowledge growth points.