Objective To investigate the relationship and potential pathways between metal(loid)exposure and the risk of polycystic ovary syndrome(PCOS)in women of childbearing age.Methods This case-control study included 200 pat...Objective To investigate the relationship and potential pathways between metal(loid)exposure and the risk of polycystic ovary syndrome(PCOS)in women of childbearing age.Methods This case-control study included 200 patients with PCOS(cases)and 896 non-PCOS controls with the age of 25-37 years.The concentrations of 29 metal(loid)s in the follicular fluid(FF)and clinical indicators in the serum were measured in all participants.Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid)exposure and PCOS risk and investigate the possible roles of clinical indicators,respectively.Results Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk(highest vs.lowest quartile:adjusted odds ratio=2.94,95%confidence interval:1.83-4.72).A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone(AMH)were strongly associated with increased PCOS risk induced by high copper exposure.The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk.Conclusion Copper may affect PCOS risk through the hypothalamic-pituitary-ovarian axis,mediated by AMH.Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.展开更多
Long-term ozone(O_(3))exposure may lead to non-communicable diseases and increase mortality risk.However,cohort-based studies are relatively rare,and inconsistent exposure metrics impair the credibility of epidemiolog...Long-term ozone(O_(3))exposure may lead to non-communicable diseases and increase mortality risk.However,cohort-based studies are relatively rare,and inconsistent exposure metrics impair the credibility of epidemiological evidence synthetization.To provide more accurate meta-estimations,this study updates existing systematic reviews by including recent studies and summarizing the quantitative associations between O_(3) exposure and cause-specific mortality risks,based on unified exposure metrics.Cross-metric conversion factors were estimated linearly by decadal observations during 1990-2019.展开更多
The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still und...The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons.展开更多
基金supported by the National Key Research&Development Program of the Ministry of Science and Technology of China[Grant No.2022YFE01349002023YFC3708305]+2 种基金the Strategy Priority Research Program(Category B)of Chinese Academy of Sciences[No.XDB0750300]the Yunnan Major Scientific and Technological Projects[Grant No.202202AG050019]the National Natural Science Foundation of China[Grant No.42077390].
文摘Objective To investigate the relationship and potential pathways between metal(loid)exposure and the risk of polycystic ovary syndrome(PCOS)in women of childbearing age.Methods This case-control study included 200 patients with PCOS(cases)and 896 non-PCOS controls with the age of 25-37 years.The concentrations of 29 metal(loid)s in the follicular fluid(FF)and clinical indicators in the serum were measured in all participants.Logistic regression analysis and mediation analysis were conducted to evaluate the associations between metal(loid)exposure and PCOS risk and investigate the possible roles of clinical indicators,respectively.Results Logistic regression analysis revealed an association between high copper levels in FF and increased PCOS risk(highest vs.lowest quartile:adjusted odds ratio=2.94,95%confidence interval:1.83-4.72).A high luteinizing hormone/follicle-stimulating hormone ratio and elevated levels of testosterone and anti-Müllerian hormone(AMH)were strongly associated with increased PCOS risk induced by high copper exposure.The mediation analysis indicated a mediating effect of AMH in the association between copper exposure and PCOS risk.Conclusion Copper may affect PCOS risk through the hypothalamic-pituitary-ovarian axis,mediated by AMH.Copper exposure and internal AMH levels are important indicators for early warning of PCOS development.
基金This study is funded by the UK Natural Environment Research Council(NERC),UK National Centre for Atmospheric Science(NCAS),Australian Research Council(DP210102076)Australian National Health and Medical Research Council(APP2000581).H.Z.S.,M.W.,and S.H.receive funding fromthe Engineering and Physical Sciences Research Council(EPSRC)via the UK Research and Innovation(UKRI)Centre for Doctoral Training in Application of Artificial Intelligence to the study of Environmental Risks(AI4ER,EP/S022961/1).A.T.A.acknowledges funding from NERC(NE/P016383/1)and through the Met Office UKRI Clean Air Program.Y.G.is supported by a Career Development Fellowship of the Australian National Health and Medical Research Council(APP1163693).All contents of this study are solely the responsibility of the grantees and do not represent the official views of the supporting agencies.
文摘Long-term ozone(O_(3))exposure may lead to non-communicable diseases and increase mortality risk.However,cohort-based studies are relatively rare,and inconsistent exposure metrics impair the credibility of epidemiological evidence synthetization.To provide more accurate meta-estimations,this study updates existing systematic reviews by including recent studies and summarizing the quantitative associations between O_(3) exposure and cause-specific mortality risks,based on unified exposure metrics.Cross-metric conversion factors were estimated linearly by decadal observations during 1990-2019.
基金We would like to express our gratitude for discussions with the researchers from the environmental exposure and human health working group of the China Cohort Consortium(http://chinacohort.bjmu.edu.cn/),as well as special thanks to Dr.Ping Zhong and Dr.Wentao Wang for their instructive guidance.This work was supported by the National Key Research and Development Program,P.R.China(Grant No.2020YFC0846300 and 2020YFC0846200)the National Natural Science Foundation of China(Grant No.41771527,41922057).
文摘The COVID-19 outbreak has already become a global pandemic and containing this rapid worldwide transmission is of great challenge.The impacts of temperature and humidity on the COVID-19 transmission rate are still under discussion.Here,we elucidated these relationships by utilizing two unique scenarios,repeated measurement and natural experiment,using the COVID-19 cases reported from January 23–February 21,2020,in China.The modeling results revealed that higher temperature was most strongly associated with decreased COVID-19 transmission at a lag time of 8 days.Relative humidity(RH)appeared to have only a slight effect.These findings were verified by assessing SARSCoV-2 infectivity under the relevant conditions of temperature(4C–37C)and RH(>40%).We concluded that temperature increase made an important,but not determined,contribution to restrain the COVID19 outbreak in China.It suggests that the emphasis of other effective controlling polices should be strictly implemented to restrain COVID19 transmission in cold seasons.