米索前列醇和卡前列甲酯栓促进剖宫产术后胃肠功能恢复的效果分析

目的 探讨米索前列醇和卡前列甲酯栓促进剖宫产术后胃肠功能恢复的效果。方法 200例剖宫产分娩的产妇按干预方式分为米索前列醇舌下组68例、卡前列甲酯栓直肠组58例及缩宫素组74例。米索前列醇舌下组术毕即给予舌下含服米索前列醇400μg,卡前列甲酯栓直肠组术毕即给予1 mg卡前列甲酯栓肛塞,缩宫素组仅静脉滴注缩宫素。观察各组肠鸣音出现时间、术后首次排气、排便时间及腹胀、腹痛发生情况。结果 与缩宫素组相比,米索前列醇舌下组、卡前列甲酯栓直肠组产妇肠鸣音出现时间及术后首次排气、排便时间明显缩短,差异有统计学意义(P<0.01),且米索前列醇舌下组短于卡前列甲酯栓直肠组(P<0.01);腹痛、腹胀、胃肠功能紊乱发生率低于缩宫素组(P<0.01)。结论 米索前列醇和卡前列甲酯栓能有效促进剖宫产术后胃肠道功能恢复,降低剖宫产术后胃肠功能不良后果发生率,且米索前列醇改善胃肠功能效果更优,更适用于基层医院,值得临床参考应用.

Injectable Nanorobot-Hydrogel Superstructure for Hemostasis and Anticancer Therapy of Spinal Metastasis

Surgery remains the standard treatment for spinal metastasis.However,uncontrolled intraoperative bleeding poses a significant challenge for adequate surgical resection and compromises surgical outcomes.In this study,we develop a thrombin(Thr)-loaded nanorobothydrogel hybrid superstructure by incorporating nanorobots into regenerated silk fibroin nanofibril hydrogels.This superstructure with superior thixotropic properties is injected percutaneously and dispersed into the spinal metastasis of hepatocellular carcinoma(HCC)with easy bleeding characteristics,before spinal surgery in a mouse model.Under near-infrared irradiation,the self-motile nanorobots penetrate into the deep spinal tumor,releasing Thr in a controlled manner.Thr-induced thrombosis effectively blocks the tumor vasculature and reduces bleeding,inhibiting tumor growth and postoperative recurrence with Au nanorod-mediated photothermal therapy.Our minimally invasive treatment platform provides a novel preoperative therapeutic strategy for HCC spinal metastasis effectively controlling intraoperative bleeding and tumor growth,with potentially reduced surgical complications and enhanced operative outcomes.

Large and nonlinear electric field response in a two-dimensional ferroelectric Rashba material

The achievement of electrical spin control is highly desirable.One promising strategy involves electrically mod-ulating the Rashba spin orbital coupling effect in materials.A semiconductor with high sensitivity in its Rashba constant to external electric fields holds great potential for short channel lengths in spin field-effect transistors,which is crucial for preserving spin coherence and enhancing integration density.Hence,two-dimensional(2D)Rashba semiconductors with large Rashba constants and significant electric field responses are highly desirable.Herein,by employing first-principles calculations,we design a thermodynamically stable 2D Rashba semiconductor,YSbTe_(3),which possesses an indirect band gap of 1.04 eV,a large Rashba constant of 1.54 eV·Åand a strong electric field response of up to 4.80 e·Å^(2).In particular,the Rashba constant dependence on the electric field shows an unusual nonlinear relationship.At the same time,YSbTe_(3)has been identified as a 2D ferroelectric material with a moderate polarization switching energy barrier(~0.33 eV per formula).By changing the electric polarization direction,the Rashba spin texture of YSbTe_(3)can be reversed.These out-standing properties make the ferroelectric Rashba semiconductor YSbTe_(3)quite promising for spintronic applications.

分布式电力负荷精益转换装置异常状态线性加权评估模型

及时、准确地了解分布式电力负荷精益转换装置状态是检修维护工作的前提和基础。在此背景下,研究一种分布式电力负荷精益转换装置异常状态线性加权评估模型。在指标初选的基础上,计算每个评估指标的累计贡献率,选出累计贡献率达到85%及以上的指标作为最终的评估指标,构建评估指标体系。利用改进层次分析法计算指标权重,然后与指标分值相乘,得出分布式电力负荷精益转换装置状态得分。对比状态等级划分标准,确定异常程度。对比实验结果表明:该方法能够有效评估分布式电力负荷精益转换装置异常状态,准确率最高达到99.2%。可以为提高装置运行质量提供参考。

五加生化胶囊治疗产后出血的疗效及对产妇凝血功能、炎症反应的影响

目的分析五加生化胶囊治疗产后出血的疗效及对产妇凝血功能、炎症反应的影响。方法2019年9月—2021年8月河北北方学院附属第二医院产科收治的产后出血产妇100例,通过随机数字表法分为研究组50例及对照组50例。两组均接受常规治疗,对照组接受米索前列醇片治疗,研究组接受五加生化胶囊联合米索前列醇片治疗,两组均治疗7 d。比较两组出血情况,治疗前、治疗后两组子宫下降高度及凝血功能、炎症反应,治疗后疗效。结果研究组用药后24 h出血量低于对照组,出血持续时间、恶露持续时间短于对照组(P<0.05)。治疗后,两组血浆纤维蛋白原(FIB)和D-二聚体(D-D),血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)水平较治疗前均降低,且研究组低于对照组(P<0.05);治疗后,两组子宫下降高度均较治疗前增加,研究组高于对照组(P<0.05)。治疗后,研究组总有效率高于对照组[94.00%(47/50)vs 80.00%(40/50),P<0.05]。结论五加生化胶囊治疗产后出血可提高出血控制效果,促进子宫复原,或许与其可调节机体凝血功能、抑制炎症反应有关,值得临床进一步研究与应用。

荧光假单胞菌SlyB的原核表达、抗原性分析及抗血浆杀菌作用

采用生物信息学方法分析SlyB的理化性质,分子克隆表达纯化获得SlyB蛋白并免疫小鼠制备SlyB抗血清,Western blotting检测抗血清特异性与效价,免疫酶联法模拟SlyB抗血清对鱼类主要致病菌的体外免疫识别作用,Western blotting分析SlyB蛋白抵抗鱼血浆的杀菌作用。结果显示:SlyB蛋白在假单胞菌属和杆菌属间同源性较好;获得SlyB最佳诱导表达条件;验证SlyB抗血清特异性较好,效价达到1∶12800;ELISA显示SlyB抗血清对嗜水气单胞菌、荧光假单胞菌和溶藻弧菌存在免疫识别作用,Western blotting表明SlyB蛋白对细菌抵抗鱼血浆的杀菌作用呈下调趋势。表明SlyB蛋白具有较好的抗原性,在蛋白亚单位疫苗上有应用前景。

嗜水气单胞菌外膜蛋白AHA1182的原核表达、纯化与免疫原性研究

为探究嗜水气单胞菌外膜蛋白AHA1182的免疫原性,依据AHA1182氨基酸序列,采用生物信息学分析嗜水气单胞菌、杀鲑气单胞菌、简氏气单胞菌、多样气单胞菌、舒氏气单胞菌、产碱普罗维登斯菌以及爱德华氏菌之间的亲缘关系;构建AHA1182原核表达菌株并确定最佳诱导表达条件;采用包涵体洗涤及SDS-PAGE切胶纯化方法获得AHA1182蛋白并免疫红鲫;利用Western blot检测红鲫抗AHA1182蛋白血清的特异性与效价;采用酶联免疫吸附(ELISA)法模拟红鲫抗AHA1182蛋白抗体血清与嗜水气单胞菌的体外相互识别作用;通过测定酸性、碱性磷酸酶(ACP、AKP)活性与细胞吞噬作用,评价非特异性免疫;利用组织病理学切片探究AHA1182蛋白免疫对红鲫内脏的影响。结果显示,AHA1182蛋白家族在不同菌株间均具有亲缘性,尤其在气单胞菌间亲缘关系较近,由此推测,AHA1182蛋白抗血清具有交叉免疫保护作用;成功克隆、表达、纯化AHA1182,最佳诱导条件:菌液浓度OD_(600)=1.0,IPTG终浓度为0.5 mmol/L,在28℃条件下诱导8 h;红鲫AHA1182蛋白抗血清具有良好的特异性,AHA1182蛋白抗体与嗜水气单胞菌特异性结合(滴度可达1∶3200);AKP、ACP、细胞吞噬作用均显示,AHA1182蛋白可激活红鲫非特异性免疫。从组织病理学切片可以看出,AHA1182蛋白对红鲫内脏结构无影响。综上,嗜水气单胞菌AHA1182蛋白具有良好的免疫原性。

Clinical application of a new device for minimally invasive circumcision

Aim： To study the clinical effects of a disposable circumcision device in treatment of male patients of different ages with either phimosis or excess foreskin. Methods： One thousand two hundred patients between the age of 5 and 95 years underwent circumcision using this procedure in the 2-year period between October 2005 and September 2007. Of these cases, 904 had excess foreskin and 296 were cases of phimosis. Results： In 96.33% of the cases the incision healed, leaving a minimal amount of the inner foreskin with no scarring and producing good cosmetic results. There were no incidents of device dislocation or damage to the frenulum. The average operative time was 2.5 min for excess foreskin, and 3.5 min for phimosis. During the 7 days of wearing the device, mild to moderate edema occurred in 10.08 % of cases with excess foreskin and in 2.58 % of those with phimosis. Edema in the frenulum was seen in 1.67% of patients, and only 0.67% had an infection of the incision. A total of 86.25% of patients reported pain due to penile erection. After removal of the device, 0.58% of the cases had minimal bleeding around the incision, and 2.42% had wound dehiscence. Conclusion： The new device can be applied to an overwhelming majority of patients with phimosis and excess foreskin. This technique is relatively simple to perform, and patients who underwent this surgery had very few complications. Antibiotics were not required and patients reported less pain than those who were circumcised using conventional methods. Circumcision with this device requires minimal tissue manipulation, and is quicker and safer than circumcision using conventional techniques.

Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery

Circular RNAs (circRNAs) are generated by head-to-tail splicing and are ubiquitously expressed in all multicellular organisms. Their important biological functions are increasingly recognized. Cerebral ischemia reperfusion injury-induced brain microvascular endothelial cell dysfunction is an initial stage of blood-brain barrier disruption. The expression profile and potential function of circRNAs in brain microvascular endothelial cells is unknown. Rat brain microvascular endothelial cells were extracted and cultured in glucose-free medium for 4 hours with 5% CO2 and 95% N2, and the medium was then replaced with complete growth medium for 6 hours. The RNA in these cells was then extracted. The circRNA was identified by Find_circ and CIRI2 software. Functional and pathway enrichment analysis of genes that were common to differentially expressed mRNAs and circRNA host genes was performed by the Database for Annotation, Visualization and Integrated Discovery Functional Annotation Tool. Miranda software was used to predict microRNAs that were potentially sponged by circRNAs. Furthermore, cytoscape depicted the circR-NA-microRNA interaction network. The results showed that there were 1288 circRNAs in normal and oxygen-glucose deprived/recovered primary brain microvascular endothelial cells. There are 211 upregulated and 326 downregulated differentially expressed circRNAs. The host genes of these differentially expressed circRNAs overlapped with those of differentially expressed mRNAs. The shared genes were further studied by functional enrichment analyses, which revealed that circRNAs may contribute to calcium ion function and the cyclic guanosine 3′,5′-monophosphate (CAMP) dependent protein kinase (PKα) signaling pathway. Next, quantitative reverse transcription polymerase chain reaction assays were performed to detect circRNA levels transcribed from the overlapping host genes. Eight out of the ten circRNAs with the highest fold-change identified by sequencing were successfully verified. Subsequently, the circRNA-microRNA interaction networks of these eight circRNAs were explored by bioinformatic analysis. These results demonstrate that altered circRNAs may be important in the pathogenesis of cerebral ischemia reperfusion injury and consequently may also be potential therapeutic targets for cerebral ischemia diseases. All animal experiments were approved by the Chongqing Medical University Committee on Animal Research, China (approval No. CQMU20180086) on March 22, 2018.

婴幼儿先天性白内障手术后视力和继发青光眼的临床分析

目的:探讨婴幼儿先天性白内障手术后视力和继发青光眼的相关分析。方法:回顾性系列病例研究。观察我院2006-05/2018-01期间收治的婴幼儿先天性白内障患儿48例86眼,均行白内障吸除、后囊膜及前段玻璃体切除手术及人工晶状体(IOL)植入术。术后随访最长13a。对最佳矫正视力(BCVA,LogMAR),继发性青光眼进行临床观察。数据采用独立样本t检验、Fisher确切概率法分析、Logistic多元回归分析进行统计学分析。结果:继发青光眼13眼(15%),BCVA 0.63±0.20;无继发青光眼73眼(85%),BCVA 0.44±0.27;两组BCVA比较有差异(t=2.417,P<0.05)。白内障摘除手术年龄≤3、>3~12、>12月龄,继发青光眼概率分别29%(6/21)、18%(6/34)、3%(1/31);Fisher分析,手术年龄≤3月龄继发青光眼概率要高于手术年龄>12月龄的(P<0.05)。继发青光眼组眼轴长度(AL)长于未继发青光眼组(t=-2.92,P=0.004);继发青光眼组屈光度小于未继发青光眼组(t=4.00,P=0.0001)。Logistic多元回归分析显示:白内障手术年龄≤12月龄是术后继发青光眼的危险因素,发生率是手术年龄>12月龄的8.372倍(OR=8.372,95%CI:1.033~67.864,P=0.047)。结论:婴幼儿先天性白内障术后可获得一定视力并有一定继发性青光眼发生率,青光眼对术后视力有极大影响。白内障手术年龄≤12月龄是术后继发青光眼的危险因素,尤其3月龄前手术的青光眼发生率远高于12月龄以后。继发青光眼患儿AL更长,屈光度更小,有着更明显的近视漂移。

One-step floating conversion of biomass into highly graphitized and continuous carbon nanotube yarns

The rapid growth of the demand for carbon nanotubes(CNTs) has greatly promoted their large-scale synthesis and development. However,the continuous production of CNT fibers by floating catalyst chemical vapor deposition(FCCVD) requires a large amount of non-renewable carbon sources. Here, the continuous production of highly graphitized CNT yarns from biomass tannic acid(TA) is reported. The chelation of TA and catalyst promotes the rapid cracking of biomass into carbon source gas, and the pyrolysis cracking produces the reducing gas, which solves the problems of the continuous production of CNT yarns using biomass. Through simple twisting, the mechanical strength of CNT yarn can reach 886 ± 46 MPa, and the electrical conductivity and graphitization(IG/ID) can reach 2 × 10^(5)S m^(-1)and 6.3, respectively. This work presents a promising solution for the continuous preparation of CNT yarns based on green raw material.

嗜水气单胞菌外膜蛋白AHA2991的原核表达、纯化与免疫原性研究

【目的】评价嗜水气单胞菌外膜蛋白AHA2991的免疫学功能,为探索嗜水气单胞菌渔用疫苗候选抗原提供理论依据。【方法】通过生物信息学分析AHA2991氨基酸序列,揭示不同菌株间的亲缘关系;分子克隆构建AHA2991表达菌株并确定最佳诱导条件;包涵体洗涤及SDS-PAGE切胶纯化获得AHA2991并免疫红鲫;Western blotting检测AHA2991红鲫血清的特异性与效价;ELISA模拟AHA2991红鲫血浆与嗜水气单胞菌的体外相互识别作用;酸性、碱性磷酸酶(ACP、AKP)测定与细胞吞噬作用评价AHA2991非特异性免疫功能;组织病理学切片探究AHA2991免疫对红鲫内脏的影响情况。【结果】AHA2991蛋白家族在不同菌株间具有同源性,不同菌株间亲缘关系较近,尤其在气单胞菌间亲缘关系更近;AHA2991的最佳诱导条件为:菌液浓度OD600=1.0,IPTG终浓度0.1 mmol/L,在28℃下诱导8 h。红鲫AHA2991抗血清具有良好的特异性,其效价为1∶800;体外AHA2991血浆对嗜水气单胞菌具有识别作用,滴度可达1∶3200;ACP、AKP指标及细胞吞噬作用均显示AHA2991激活红鲫非特异性免疫;组织病理学切片表明AHA2991免疫对红鲫内脏结构无影响。【结论】嗜水气单胞菌AHA2991具有良好的免疫原性,有望成为嗜水气单胞菌渔用疫苗的候选抗原成分。

鱼类致病荧光假单胞菌外膜蛋白LolB多克隆抗体制备、鉴定与免疫活性分析

以荧光假单胞菌的外膜蛋白LolB为研究对象,评价其免疫学功能。生物信息学分析各菌株间LolB的亲缘关系;分子克隆构建LolB蛋白的表达菌株并确定最佳诱导表达条件;SDS-PAGE切胶纯化LolB蛋白并免疫红鲫;Western blotting检测红鲫LolB血清的特异性与效价,ELISA体外模拟红鲫LolB血清与荧光假单胞菌的相互识别作用,免疫因子(ACP、AKP、LZM、IgM)与细胞吞噬作用测定,抗氧化因子(CAT、SOD、MDA、GSH-Px)、炎症因子(IL-1β、TNF-α)表达分析及组织病理学探究LolB蛋白的免疫保护作用。结果显示,LolB在假单胞菌属间同源性和亲缘性更近,LolB抗血清可能提供交叉免疫保护作用。原核表达纯化LolB蛋白,获得最佳诱导表达条件。红鲫LolB抗血清具有较好特异性,效价达1∶200;且抗血清与荧光假单胞菌在体外存在相互识别作用;免疫因子以及细胞吞噬作用均呈上升趋势,表明LolB激活红鲫的非特异性免疫。红鲫免疫LolB蛋白攻毒荧光假单胞菌后,抗氧化因子以及炎症因子呈下降趋势,表明LolB蛋白具有抗氧化和消炎作用;组织病理学切片显示LolB蛋白保护红鲫的肾脏、脾脏、肠道的完整性。荧光假单胞菌LolB具有良好的免疫原性,有望成为渔用疫苗的候选抗原。

A DRL-Based Container Placement Scheme with Auxiliary Tasks

Container is an emerging virtualization technology and widely adopted in the cloud to provide services because of its lightweight,flexible,isolated and highly portable properties.Cloud services are often instantiated as clusters of interconnected containers.Due to the stochastic service arrival and complicated cloud environment,it is challenging to achieve an optimal container placement(CP)scheme.We propose to leverage Deep Reinforcement Learning(DRL)for solving CP problem,which is able to learn from experience interacting with the environment and does not rely on mathematical model or prior knowledge.However,applying DRL method directly dose not lead to a satisfying result because of sophisticated environment states and huge action spaces.In this paper,we propose UNREAL-CP,a DRL-based method to place container instances on servers while considering end to end delay and resource utilization cost.The proposed method is an actor-critic-based approach,which has advantages in dealing with the huge action space.Moreover,the idea of auxiliary learning is also included in our architecture.We design two auxiliary learning tasks about load balancing to improve algorithm performance.Compared to other DRL methods,extensive simulation results show that UNREAL-CP performs better up to 28.6%in terms of reducing delay and deployment cost with high training efficiency and responding speed.

基于大数据的10kV配电线路分段线损计算方法

由于配电网规模增大、支路增多,10 kV配电线路计算一直存在计算准确度不足的问题。针对上述问题,提出基于大数据的10 kV配电线路分段线损计算方法。划分待计算的配电线路,将配电线路划分为不同的区段,采集各个区段上的线路长度、配电变压器总容量、月无功功率电量、月有功功率电量以及负荷电流不平衡度等5个特征参量。以大数据分析中的RBF神经网络为基础,结合遗传算法改进RBF神经网络的隐含层中心选择、宽度以及输出权值等3个结构参数,构建10 kV配电线路分段线损计算模型,计算10 kV配电线路分段线损值。结果表明:所研究方法得出的线损计算结果与样本训练输出值之间的绝对误差和相对误差百分比均较小,由此说明所研究方法的计算准确度更高。

CPT-Based estimation of undrained shear strength of fine-grained soils in the Huanghe River Delta

The Huanghe River(Yellow River)Delta has a wide distribution of fine-grained soils.Fluvial alluviation,erosion,and wave loads affect the shoal area,resulting complex physical and mechanical properties to sensitive finegrained soil located at the river-sea boundary.The cone penetration test(CPT)is a convenient and effective in situ testing method which can accurately identify various soil parameters.Studies on undrained shear strength only roughly determine the fine content(FC)without making the FC effect clear.We studied four stations formed in different the Huanghe River Delta periods.We conducted in situ CPT and corresponding laboratory tests,examined the fine content influence on undrained shear strength(S_(u)),and determined the cone coefficient(N_(k)).The conclusions are as follows.(1)The fine content in the area exceeded 90%,and the silt content was high,accounting for more than 70%of all fine particle compositions.(2)The undrained shear strength gradually increased with depth with a maximum of approximately 250 kPa.When the silt content was lower than 60%–70%,the undrained shear strength decreased.(3)The silt and clay content influenced undrained shear strength,and the fitted f_(s)h/q_(t) function model was established,which could be applied to strata with a high fine content.The cone coefficients were between 20 and 25,and the overconsolidated soil layer had a greater cone coefficient.

Diagnostic and prognostic role of neutrophil-to-lymphocyte ratio(NLR) in sepsis

Objective: To evaluate neutrophil-to-lymphocyte ratio(NLR) as diagnostic and prognostic role in sepsis. Methods: It was a prospective, observational study, conducted in Intensive Care Unit of Mianyang Central Hospital , from August 2017 to August 2018. A total of 37 cases of newly diagnosed cases of sepsis were included in the study and 20 healthy adults were taken as controls. According to the mortality within 30 d,patients with sepsis were divided into survival group (n=15) and death group (n=22) . The white blood cell (WBC), neutrophils count (NEU), lymphocyte count (LYM), and NLR in peripheral blood were recorded at 1, 3,5,7 days after admission for patients . Logistic regression analysis was used to evaluate the risk factors for predicting the outcome, and receiver-operating characteristic curve (ROC) was plotted for evaluating the value of these factors on the 30-day prognosis. Results: NLR on day 1 (NLR1) of sepsis was signifcantly higher as compared to controls (P<0.001), with far higher diagnostic efficiency (AUC=0.959) than WBC (AUC=0.788) and equivalent to NEU% (AUC=0.942);WBC and NLR on day 7 (NLR7) is independent risk factors for 30-day mortality of sepsis patients and is helpful to predict the prognosis of sepsis. Conclusion: NLR can be a convenient and useful diagnostic and prognostic marker in sepsis and is of great clinical applicative value for primary hospitals without ability to detect other costly biomarkers and for emergency department.

A luminescent one-dimensional covalent organic framework for organic arsenic sensing in water

Roxarsone(ROX)is a commonly used antibacterial and growth-promoting additive to animal feed.The development of an effective method for detecting ROX and its conversion products is of importance because of their potential harm to human health and ecosystem.Herein,we report the designed synthesis of a novel one-dimensional covalent organic framework(1D COF),named EP-COF,and its application as a fluorescent probe for ROX sensing.EP-COF is constructed based on imine linkages,exhibiting high crystallinity,strong fluorescence emission,and good dispersibility in water.It displays a remarkable capability to efficiently detect ROX,with an impressive detection limit of 4.5 nmol/L.Moreover,EP-COF also offers advantages of excellent selectivity,and high structural stability.This work not only presents a promising approach for the detection of harmful substances like ROX,but also serves as a valuable reference for exploring application of 1D COFs in chemical sensing.

Large-scale blow spinning of heat-resistant nanofibrous air filters

Particulate matter(PM)pollution has become a serious problem worldwide and various kinds of nanofibrous filters aiming to solve the problem have been developed.It is urgent to remove PM from high-temperature pollution sources,such as industrial emissions,coal furnaces,and automobile exhaust gases.However,filtration at pollution sources remains challenging because most existing air filters are not resistant to high temperature.Herein,heat-resistant polyimide(PI)nanofibrous air filters are fabricated via a simple and scalable solution blow-spinning method.These air filters show excellent thermal stability at high temperature up to 420℃.They exhibit a filtration efficiency as high as 99.73%at ambient temperature and over 97%at 300℃.In addition,a field test shows that the filters remove>97%of PM from the car exhaust fumes.Hence,the blow-spun PI nanofibrous membranes combined with the facile preparation strategy have great potential in high temperature air filtration fields and other similar applications such as water purification and protein separation.

Flexible Ceramic Fibers: Recent Development in Preparation and Application

Flexible ceramic fibers(FCFs)have been developed for various advanced applications due to their superior mechanical flexibility,high temperature resistance,and excellent chemical stability.In this article,we present an overview on the recent progress of FCFs in terms of materials,fabrication methods,and applications.We begin with a brief introduction to FCFs and the materials for preparation of FCFs.After that,various methods for preparation of FCFs are discussed,including centrifugal spinning,electrospinning,solution blow spinning,self-assembly,chemical vapor deposition,atomic layer deposition,and polymer conversion.Recent applications of FCFs in various fields are further illustrated in detail,including thermal insulation,air filtration,water treatment,sound absorption,electromagnetic wave absorption,battery separator,catalytic application,among others.Finally,some perspectives on the future directions and opportunities for the preparation and application of FCFs are highlighted.We envision that this review will provide readers with some meaningful guidance on the preparation of FCFs and inspire them to explore more potential applications.