Rockbursts have become a significant hazard in underground mining,underscoring the need for a robust early warning model to ensure safety management.This study presents a novel approach for rockburst prediction,integr...Rockbursts have become a significant hazard in underground mining,underscoring the need for a robust early warning model to ensure safety management.This study presents a novel approach for rockburst prediction,integrating the Mann-Kendall trend test(MKT)and multi-indices fusion to enable real-time and quantitative assessment of rockburst hazards.The methodology employed in this study involves the development of a comprehensive precursory index library for rockbursts.The MKT is then applied to analyze the real-time trend of each index,with adherence to rockburst characterization laws serving as the warning criterion.By employing a confusion matrix,the warning effectiveness of each index is assessed,enabling index preference determination.Ultimately,the integrated rockburst hazard index Q is derived through data fusion.The results demonstrate that the proposed model achieves a warning effectiveness of 0.563 for Q,surpassing the performance of any individual index.Moreover,the model’s adaptability and scalability are enhanced through periodic updates driven by actual field monitoring data,making it suitable for complex underground working environments.By providing an efficient and accurate basis for decision-making,the proposed model holds great potential for the prevention and control of rockbursts.It offers a valuable tool for enhancing safety measures in underground mining operations.展开更多
Near-infrared(NIR)transparent inverted all-inorganic perovskite solar cells(PSCs)are excellent top cell candidates in tandem applications.An essential challenge is the replacement of metal contacts with transparent co...Near-infrared(NIR)transparent inverted all-inorganic perovskite solar cells(PSCs)are excellent top cell candidates in tandem applications.An essential challenge is the replacement of metal contacts with transparent conductive oxide(TCO)electrodes,which requires the introduction of a buffer layer to prevent sputtering damage.In this study,we show that the conventional buffers(i.e.,small organic molecules and atomic layer deposited metal oxides)used for organic-inorganic hybrid perovskites are not applicable to all-inorganic perovskites,due to non-uniform coverage of the vulnerable layers underneath,deterioration upon ion bombardment and moisture induced perovskite phase transition,A thin film of metal oxide nanoparticles by the spin-coating method serves as a non-destructive buffer layer for inorganic PSCs.All-inorganic inverted near-infrared-transparent PSCs deliver a PCE of 17.46%and an average transmittance of 73.7%between 780 and 1200 nm.In combination with an 18.56%Cu(In,Ga)Se_(2) bottom cell,we further demonstrate the first all-inorganic perovskite/CIGS 4-T tandem solar cell with a PCE of 24.75%,which exhibits excellent illumination stability by maintaining 86.7%of its initial efficiency after 1400 h.The non-destructive buffer lays the foundation for efficient and stable NIR-transparent inverted inorganic perovskite solar cells and perovskite-based tandems.展开更多
Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases.However,no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and...Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases.However,no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on cardiometabolic health,gut microbiota,and psychological status in healthy people.A 4-week step-wise misaligned-realigned controlled-feeding trial with a 2×2 factorial design(sleep and diet)was conducted on healthy young adults.At first,subjects experienced a one-week circadian rhythm misalignment with a high-fat fast-food diet,extended eating window,and delayed sleep schedules,then gradually transited to a complete circadian rhythm realignment with a high-fiber balanced diet,8-h timerestricted eating,and normal sleep schedules.Circadian rhythm misalignment led to significantly higher levels of fasting glucose and homeostatic model assessment for insulin resistance(HOMA-IR)of subjects compared to baseline and failed to recover to the baseline level in circadian rhythm realignments.Notably,the incremental area under the curve(iAUC)of postprandial glucose decreased with circadian rhythm adjustments as compared to that in circadian rhythm misalignment,suggesting circadian rhythm realignment by sleep or/and diet could partly restore glucose metabolism impaired by a short-term circadian rhythm misalignment.However,circadian rhythm changes did not result in overall perturbations of gut microbiota diversities.展开更多
Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental factors.Healing full-thickness skin defects becomes especially challenging wh...Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental factors.Healing full-thickness skin defects becomes especially challenging when infections and vascular injuries are involved.Traditional wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound healing.To address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic properties.Methods:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic agent.Results:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air permeability.It not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo assays.Conclusion:These findings highlight the immense potential of this wound dressing material for future clinical applications.展开更多
BACKGROUND Vascular injury during thoracoscopic surgery for esophageal cancer is a rare but life-threatening complication that can lead to severe hypotension and hypoxemia.Anesthesiologists need to provide rapid and e...BACKGROUND Vascular injury during thoracoscopic surgery for esophageal cancer is a rare but life-threatening complication that can lead to severe hypotension and hypoxemia.Anesthesiologists need to provide rapid and effective treatment to save patients'lives.CASE SUMMARY A 54-year-old male patient was scheduled to undergo a thoracoscopic-assisted radical resection of esophageal cancer through the upper abdomen and right chest.While dissociating the esophagus from the carina through the right chest,unexpected profuse bleeding occurred from a suspected pulmonary vascular hemorrhage.While the surgeon attempted to achieve hemostasis,the patient developed severe hypoxemia.The anesthesiologist implemented continuous positive airway pressure(CPAP)using a bronchial blocker(BB),which effectively improved the patient’s oxygenation and the operation was completed success-fully.CONCLUSION CPAP using a BB can resolve severe hypoxemia caused by accidental injury of the left inferior pulmonary vein during surgery.展开更多
The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous or...The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous orbit(IGSO) satellites. Due to the geosynchronous characteristics of GEO and IGSO, GEO satellites and IGSO satellites often need to perform orbital maneuvers, which can affect the signal-inspace(SIS) availability performance of BeiDou satellites. A two-step detection method for BeiDou satellite orbital maneuvers has been proposed in this paper. The first step is to identify orbital maneuvers based on time series analysis of broadcast ephemeris, and the second step is to verify orbital maneuvers based on bidirectional orbit prediction. The two-step detection method was used to detect the orbital maneuvers of BeiDou satellites in 2019. Through the double guarantees of identification and verification,the detection accuracy of BeiDou satellite orbital maneuvers has been effectively improved. And the orbital maneuver detection results are continued to be used to assess the SIS availability of BeiDou satellites. The results show that the availability loss of GEO satellite orbital maneuvers is about 0.45%-1.07%, and the availability loss of IGSO satellite orbital maneuvers is about 0.12%-0.19%.展开更多
This study was designed to investigate the roles of RASAL2 in cervical cancer(CC).Methods:Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and Ju...This study was designed to investigate the roles of RASAL2 in cervical cancer(CC).Methods:Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and June 2014.Real-time polymerase chain reaction and western blotting were performed to analyze the expression of RASAL2 mRNA and protein in these tissues,CC cell lines,and normal cervical cells.Over-expression and silencing of RASAL2 were induced after transfection,and the migration,invasion,and proliferation of the CC cell lines were examined.Results:RASAL2 mRNA and protein expressions were significantly down-regulated in CC tissues and cell lines than in adjacent tissues and normal cervical cells,respectively.While low RASAL2 expression correlated with advanced stage and metastasis of CC,its over-expression significantly inhibited proliferation and metastasis of CC cells and induced apoptosis.Under in vitro conditions,silencing of RASAL2 expression could significantly increase the proliferation,invasion,and migration of CC cells.Conclusion:RASAL2 functioned as a tumor suppressor in CC,and was down-regulated in CC tissue samples and cell lines.展开更多
Realtime analyzing the feeding behavior of fish is the premise and key to accurate guidance on feeding.The identification of fish behavior using a single information is susceptible to various factors.To overcome the p...Realtime analyzing the feeding behavior of fish is the premise and key to accurate guidance on feeding.The identification of fish behavior using a single information is susceptible to various factors.To overcome the problems,this paper proposes an adaptive deep modular co-attention unified multi-modal transformers(DMCA-UMT).By fusing the video,audio and water quality parameters,the whole process of fish feeding behavior could be identified.Firstly,for the input video,audio and water quality parameter information,features are extracted to obtain feature vectors of different modalities.Secondly,deep modular co-attention(DMCA)is introduced on the basis of the original cross-modal encoder,and the adaptive learnable weights are added.The feature vector of video and audio joint representation is obtained by automatic learning based on fusion contribution.Finally,the information of visual-audio modality fusion and text features are used to generate clip-level moment queries.The query decoder decodes the input features and uses the prediction head to obtain the final joint moment retrieval,which is the start-end time of feeding the fish.The results show that the mAP Avg of the proposed algorithm reaches 75.3%,which is37.8%higher than that of unified multi-modal transformers(UMT)algorithm.展开更多
Background:To develop a protein-protein interaction network of Paroxysmal nocturnal hemoglobinuria(PNH)and Aplastic anemia(AA)based on genetic genes and to predict pathways underlying the molecular complexes in the ne...Background:To develop a protein-protein interaction network of Paroxysmal nocturnal hemoglobinuria(PNH)and Aplastic anemia(AA)based on genetic genes and to predict pathways underlying the molecular complexes in the network.Methods:In this research,the PNH and AA-related genes were screened through Online Mendelian Inheritance in Man(OMIM).The plugins and Cytoscape were used to search literature and build a protein-protein interaction network.Results:The protein-protein interaction network contains two molecular complexes that are five higher than the correlation integral values.The target genes of this study were obtained:CD59,STAT3,TERC,TNF,AKT1,C5AR1,EPO,IL6,IL10 and so on.We also found that many factors regulate biological behaviors:neutrophils,macrophages,vascular endothelial growth factor,immunoglobulin,interleukin,cytokine receptor,interleukin-6 receptor,tumor necrosis factor,and so on.This research provides a bioinformatics foundation for further explaining the mechanism of common development of both.Conclusion:This indicates that the PNH and AA is a complex process regulated by many cellular pathways and multiple genes.展开更多
BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-...BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality.展开更多
On the basis of the massive amount of published literature and the long-term practice of our research group in the field of prevention and control of rockburst,the research progress and shortcomings in understanding t...On the basis of the massive amount of published literature and the long-term practice of our research group in the field of prevention and control of rockburst,the research progress and shortcomings in understanding the rockburst phenomenon have been comprehensively in-vestigated.This study focuses on the occurrence mechanism and monitoring and early warning technology for rockburst in coal mines.Results showed that the prevention and control of rockburst had made significant progress.However,with the increasing mining depth,several unre-solved concerns remain challenging.From the in-depth research and analysis,it can be inferred that rockburst disasters involve three main problems,i.e.,the induction factors are complicated,the mechanism is still unclear,and the accuracy of the monitoring equipment and multi-source stereo monitoring technology is insufficient.The monitoring and warning standards of rockburst need to be further clarified and im-proved.Combined with the Internet of Things,cloud computing,and big data,a study of the trend of rockburst needs to be conducted.Further-more,the mechanism of multiphase and multi-field coupling induced by rockburst on a large scale needs to be explored.A multisystem and multiparameter integrated monitoring and early warning system and remote monitoring cloud platform for rockburst should be explored and developed.High-reliability sensing technology and equipment and perfect monitoring and early warning standards are considered to be the de-velopment direction of rockburst in the future.This research will help experts and technicians adopt effective measures for controlling rock-burst disasters.展开更多
Emerging evidence indicates that pentraxin 3 is an acute-phase protein that is linked with the immune response to inflammation.It is also a newly discovered marker of anti-inflammatory A2 reactive astrocytes,and poten...Emerging evidence indicates that pentraxin 3 is an acute-phase protein that is linked with the immune response to inflammation.It is also a newly discovered marker of anti-inflammatory A2 reactive astrocytes,and potentially has multiple protective effects in stroke;however,its role in the adult brain after traumatic brain injury is unknown.In the present study,a moderate model of traumatic brain injury in mice was established using controlled cortical impact.The models were intraventricularly injected with recombinant pentraxin 3(the recombinant pentraxin 3 group)or an equal volume of vehicle(the control group).The sham-operated mice underwent craniotomy,but did not undergo the controlled cortical impact.The potential neuroprotective and neuroregenerative roles of pentraxin 3 were investigated on days 14 and 21 after traumatic brain injury.Western blot assay showed that the expression of endogenous pentraxin 3 was increased after traumatic brain injury in mice.Furthermore,the neurological severity test and wire grip test revealed that recombinant pentraxin 3 treatment reduced the neurological severity score and increased the wire grip score,suggesting an improved recovery of sensory-motor functions.The Morris water maze results demonstrated that recombinant pentraxin 3 treatment reduced the latency to the platform,increased the time spent in the correct quadrant,and increased the number of times traveled across the platform,thus suggesting an improved recovery of cognitive function.In addition,to investigate the effects of pentraxin 3 on astrocytes,specific markers of A2 astrocytes were detected in primary astrocyte cultures in vitro using western blot assay.The results demonstrated that pentraxin 3 administration activates A2 astrocytes.To explore the protective mechanisms of pentraxin 3,immunofluorescence staining was used.Intraventricular injection of recombinant pentraxin 3 increased neuronal maintenance in the peri-injured cortex and ipsilateral hippocampus,increased the number of doublecortin-positive neural progenitor cells in the subventricular and subgranular zones,and increased the number of bromodeoxyuridine(proliferation)and neuronal nuclear antigen(mature neuron)double-labeled cells in the hippocampus and peri-injured cortex.Pentraxin 3 administration also increased the number of neurospheres and the number of bromodeoxyuridine and doublecortin double-labeled cells in neurospheres,and enhanced the proliferation of neural progenitor cells in primary neural progenitor cell cultures in vitro.In conclusion,recombinant pentraxin 3 administration activated A2 astrocytes,and consequently improved the recovery of neural function by increasing neuronal survival and enhancing neurogenesis.All experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Chongqing Medical University,China on March 1,2016.展开更多
AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This stu...AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.展开更多
We use a two‐step hydrothermal method to successfully synthesize Sn2Nb2O7nanocrystals with an average size of approximately20nm.The as‐obtained samples are characterized by powder X‐ray diffraction,ultraviolet‐vis...We use a two‐step hydrothermal method to successfully synthesize Sn2Nb2O7nanocrystals with an average size of approximately20nm.The as‐obtained samples are characterized by powder X‐ray diffraction,ultraviolet‐visible diffuse reflectance spectroscopy,Brunauer‐Emmett‐Teller analysis,scanning electron microscopy,and transmission electron microscopy.The photocatalytic activity of the Sn2Nb2O7nanocrystals is evaluated by photocatalytic water splitting under visible light irradiation.The Sn2Nb2O7nanocrystals with a large surface area of52.2m2/g show an enhanced visible‐light‐driven photocatalytic H2production activity,approximately5.5times higher than that of bulk Sn2Nb2O7powder.The higher photocatalytic activity of Sn2Nb2O7nanocrystals is mainly attributed to its relatively high dispersity of nanosized particles and larger specific surface area when compared with the bulk powder.展开更多
A theoretical model of phase change heat sink was established in terms of thermal resistance network. The influence of different parameters on the thermal resistance was analyzed and the crucial impact factors were de...A theoretical model of phase change heat sink was established in terms of thermal resistance network. The influence of different parameters on the thermal resistance was analyzed and the crucial impact factors were determined. Subsequently, the forming methods including ploughing-extrusion and stamping method of boiling enhancement structure at evaporation surface were investigated, upon which three-dimensional microgroove structure was fabricated to improve the efficiency of evaporation. Moreover, the crucial parameters related to the fabrication of miniaturized phase change heat sink were optimized. The heat transfer performance of the heat sink was tested. Results show that the developed phase change heat sink has excellent heat transfer performance and is suitable for high power LED applications.展开更多
基金The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China(Grant Nos.52011530037 and 51904019)the Fundamental Research Funds for the Central Universities and the Youth Teacher International Exchange&Growth Program(Grant No.QNXM20210004).We also greatly appreciate the assistance provided by Kuangou coal mine,China Energy Group Xinjiang Energy Co.,Ltd.
文摘Rockbursts have become a significant hazard in underground mining,underscoring the need for a robust early warning model to ensure safety management.This study presents a novel approach for rockburst prediction,integrating the Mann-Kendall trend test(MKT)and multi-indices fusion to enable real-time and quantitative assessment of rockburst hazards.The methodology employed in this study involves the development of a comprehensive precursory index library for rockbursts.The MKT is then applied to analyze the real-time trend of each index,with adherence to rockburst characterization laws serving as the warning criterion.By employing a confusion matrix,the warning effectiveness of each index is assessed,enabling index preference determination.Ultimately,the integrated rockburst hazard index Q is derived through data fusion.The results demonstrate that the proposed model achieves a warning effectiveness of 0.563 for Q,surpassing the performance of any individual index.Moreover,the model’s adaptability and scalability are enhanced through periodic updates driven by actual field monitoring data,making it suitable for complex underground working environments.By providing an efficient and accurate basis for decision-making,the proposed model holds great potential for the prevention and control of rockbursts.It offers a valuable tool for enhancing safety measures in underground mining operations.
基金financially supported by the National Natural Science Foundation of China (22279083,22109166,52202183)Guangdong Basic and Applied Basic Research Foundation (Grant No.2019A1515011136,2022B1515120006,2023B1515120041,2414050001473)+3 种基金Guangdong Province Higher Vocational Colleges and Schools Pearl River Scholar Funded SchemeGuangdong Provincial Key Laboratory Program (2021B1212040001)from the Department of Science and Technology of Guangdong ProvinceBeijing Institute of TechnologySongshan Lake Materials Laboratory。
文摘Near-infrared(NIR)transparent inverted all-inorganic perovskite solar cells(PSCs)are excellent top cell candidates in tandem applications.An essential challenge is the replacement of metal contacts with transparent conductive oxide(TCO)electrodes,which requires the introduction of a buffer layer to prevent sputtering damage.In this study,we show that the conventional buffers(i.e.,small organic molecules and atomic layer deposited metal oxides)used for organic-inorganic hybrid perovskites are not applicable to all-inorganic perovskites,due to non-uniform coverage of the vulnerable layers underneath,deterioration upon ion bombardment and moisture induced perovskite phase transition,A thin film of metal oxide nanoparticles by the spin-coating method serves as a non-destructive buffer layer for inorganic PSCs.All-inorganic inverted near-infrared-transparent PSCs deliver a PCE of 17.46%and an average transmittance of 73.7%between 780 and 1200 nm.In combination with an 18.56%Cu(In,Ga)Se_(2) bottom cell,we further demonstrate the first all-inorganic perovskite/CIGS 4-T tandem solar cell with a PCE of 24.75%,which exhibits excellent illumination stability by maintaining 86.7%of its initial efficiency after 1400 h.The non-destructive buffer lays the foundation for efficient and stable NIR-transparent inverted inorganic perovskite solar cells and perovskite-based tandems.
文摘Epidemiological studies showed that night workers are at higher risk of developing chronic metabolic diseases.However,no study has investigated the changes in circadian rhythms caused by a combined effect of sleep and diet in a real-life setting on cardiometabolic health,gut microbiota,and psychological status in healthy people.A 4-week step-wise misaligned-realigned controlled-feeding trial with a 2×2 factorial design(sleep and diet)was conducted on healthy young adults.At first,subjects experienced a one-week circadian rhythm misalignment with a high-fat fast-food diet,extended eating window,and delayed sleep schedules,then gradually transited to a complete circadian rhythm realignment with a high-fiber balanced diet,8-h timerestricted eating,and normal sleep schedules.Circadian rhythm misalignment led to significantly higher levels of fasting glucose and homeostatic model assessment for insulin resistance(HOMA-IR)of subjects compared to baseline and failed to recover to the baseline level in circadian rhythm realignments.Notably,the incremental area under the curve(iAUC)of postprandial glucose decreased with circadian rhythm adjustments as compared to that in circadian rhythm misalignment,suggesting circadian rhythm realignment by sleep or/and diet could partly restore glucose metabolism impaired by a short-term circadian rhythm misalignment.However,circadian rhythm changes did not result in overall perturbations of gut microbiota diversities.
基金support from National Natural Science Foundation of China(Grant No 52105295)the Natural Science Foundation of Jiangsu Province(Grant No BK20210082)+3 种基金Natural Science of Foundation of the Jiangsu Higher Education Institutions of China(Grant No 21KJB460003)Basic Research Project of Changzhou Medical Center of Nanjing Medical University(CMCB202314),Qinghai Province Health System Guidance Plan Project(2022-wjzdx-106 and 2023-wjzdx-104)Top Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project(2022CZBJ059 and 2022CZBJ061)Nursing research project of the Second People's Hospital of Changzhou(2022HZD002).
文摘Background:Skin,being a vital organ that regulates physiological responses in the human body,is prone to injury from external environmental factors.Healing full-thickness skin defects becomes especially challenging when infections and vascular injuries are involved.Traditional wound dressings with single functions,such as antibacterial or angiogenic properties,fall short in achieving rapid wound healing.To address this,there is a need to develop wound dressing materials that possess both effective antibacterial and angiogenic properties.Methods:In this study,we utilized electrospinning technology to fabricate hyaluronic acid-cellulose acetate fibrous membrane dressings,incorporating poly(ionic liquid)as an antibacterial polymer and deferoxamine as an angiogenic agent.Results:The resulting fibrous membrane dressing contained poly(ionic liquid)and deferoxamin showcased a microporous structure,drug-releasing capabilities,and excellent air permeability.It not only demonstrated highly effective antibacterial properties but also exhibited remarkable angiogenesis,thereby promoting the healing of full-thickness skin defect wounds in both in vitro and in vivo assays.Conclusion:These findings highlight the immense potential of this wound dressing material for future clinical applications.
文摘BACKGROUND Vascular injury during thoracoscopic surgery for esophageal cancer is a rare but life-threatening complication that can lead to severe hypotension and hypoxemia.Anesthesiologists need to provide rapid and effective treatment to save patients'lives.CASE SUMMARY A 54-year-old male patient was scheduled to undergo a thoracoscopic-assisted radical resection of esophageal cancer through the upper abdomen and right chest.While dissociating the esophagus from the carina through the right chest,unexpected profuse bleeding occurred from a suspected pulmonary vascular hemorrhage.While the surgeon attempted to achieve hemostasis,the patient developed severe hypoxemia.The anesthesiologist implemented continuous positive airway pressure(CPAP)using a bronchial blocker(BB),which effectively improved the patient’s oxygenation and the operation was completed success-fully.CONCLUSION CPAP using a BB can resolve severe hypoxemia caused by accidental injury of the left inferior pulmonary vein during surgery.
基金This research was funded by the Shandong Provincial Natural Science Foundation(ZR2022QD100,ZR2022QE221)the Weifang University of Science and Technology Doctoral Research Startup Fund(2021KJBS16).
文摘The space constellation of the BeiDou navigation satellite system(BDS) is a hybrid constellation containing medium earth orbit(MEO) satellites, geostationary earth orbit(GEO) satellites, and inclined geosynchronous orbit(IGSO) satellites. Due to the geosynchronous characteristics of GEO and IGSO, GEO satellites and IGSO satellites often need to perform orbital maneuvers, which can affect the signal-inspace(SIS) availability performance of BeiDou satellites. A two-step detection method for BeiDou satellite orbital maneuvers has been proposed in this paper. The first step is to identify orbital maneuvers based on time series analysis of broadcast ephemeris, and the second step is to verify orbital maneuvers based on bidirectional orbit prediction. The two-step detection method was used to detect the orbital maneuvers of BeiDou satellites in 2019. Through the double guarantees of identification and verification,the detection accuracy of BeiDou satellite orbital maneuvers has been effectively improved. And the orbital maneuver detection results are continued to be used to assess the SIS availability of BeiDou satellites. The results show that the availability loss of GEO satellite orbital maneuvers is about 0.45%-1.07%, and the availability loss of IGSO satellite orbital maneuvers is about 0.12%-0.19%.
基金supported by the National Natural Science Foundation of China(Grant No.81572559)the Shandong Key Research and Development Plan(Grant No.2017CXGC1210).
文摘This study was designed to investigate the roles of RASAL2 in cervical cancer(CC).Methods:Fifty-four CC tissues and 33 adjacent tissues were obtained from CC patients admitted to our hospital between March 2012 and June 2014.Real-time polymerase chain reaction and western blotting were performed to analyze the expression of RASAL2 mRNA and protein in these tissues,CC cell lines,and normal cervical cells.Over-expression and silencing of RASAL2 were induced after transfection,and the migration,invasion,and proliferation of the CC cell lines were examined.Results:RASAL2 mRNA and protein expressions were significantly down-regulated in CC tissues and cell lines than in adjacent tissues and normal cervical cells,respectively.While low RASAL2 expression correlated with advanced stage and metastasis of CC,its over-expression significantly inhibited proliferation and metastasis of CC cells and induced apoptosis.Under in vitro conditions,silencing of RASAL2 expression could significantly increase the proliferation,invasion,and migration of CC cells.Conclusion:RASAL2 functioned as a tumor suppressor in CC,and was down-regulated in CC tissue samples and cell lines.
基金supported by the Beijing Natural Science Foundation(No.6212007)the National Key Technology R&D Program of China(No.2022YFD2001701)the Youth Research Fund of Beijing Academy of Agricultural and Forestry Sciences(No.QNJJ202014)。
文摘Realtime analyzing the feeding behavior of fish is the premise and key to accurate guidance on feeding.The identification of fish behavior using a single information is susceptible to various factors.To overcome the problems,this paper proposes an adaptive deep modular co-attention unified multi-modal transformers(DMCA-UMT).By fusing the video,audio and water quality parameters,the whole process of fish feeding behavior could be identified.Firstly,for the input video,audio and water quality parameter information,features are extracted to obtain feature vectors of different modalities.Secondly,deep modular co-attention(DMCA)is introduced on the basis of the original cross-modal encoder,and the adaptive learnable weights are added.The feature vector of video and audio joint representation is obtained by automatic learning based on fusion contribution.Finally,the information of visual-audio modality fusion and text features are used to generate clip-level moment queries.The query decoder decodes the input features and uses the prediction head to obtain the final joint moment retrieval,which is the start-end time of feeding the fish.The results show that the mAP Avg of the proposed algorithm reaches 75.3%,which is37.8%higher than that of unified multi-modal transformers(UMT)algorithm.
文摘Background:To develop a protein-protein interaction network of Paroxysmal nocturnal hemoglobinuria(PNH)and Aplastic anemia(AA)based on genetic genes and to predict pathways underlying the molecular complexes in the network.Methods:In this research,the PNH and AA-related genes were screened through Online Mendelian Inheritance in Man(OMIM).The plugins and Cytoscape were used to search literature and build a protein-protein interaction network.Results:The protein-protein interaction network contains two molecular complexes that are five higher than the correlation integral values.The target genes of this study were obtained:CD59,STAT3,TERC,TNF,AKT1,C5AR1,EPO,IL6,IL10 and so on.We also found that many factors regulate biological behaviors:neutrophils,macrophages,vascular endothelial growth factor,immunoglobulin,interleukin,cytokine receptor,interleukin-6 receptor,tumor necrosis factor,and so on.This research provides a bioinformatics foundation for further explaining the mechanism of common development of both.Conclusion:This indicates that the PNH and AA is a complex process regulated by many cellular pathways and multiple genes.
基金Supported by National Thirteen Five-year Science and Technology Major Project of China,No.2018ZX10725506-002National Twelve Five-year Science and Technology Major Project of China,No.2012ZX10005-005.
文摘BACKGROUND Patients with hepatitis B virus-associated acute-on-chronic liver failure(HBVACLF)present a complex and poor prognosis.Systemic inflammation plays an important role in its pathogenesis,and interleukin-6(IL-6)as a pro-inflammatory cytokine is related with severe liver impairment and also plays a role in promoting liver regeneration.Whether serum IL-6 influences HBV-ACLF prognosis has not been studied.AIM To determine the impact of serum IL-6 on outcome of patients with HBV-ACLF.METHODS We performed a retrospective study of 412 HBV-ACLF patients.The findings were analyzed with regard to mortality and the serum IL-6 level at baseline,as well as dynamic changes of serum IL-6 within 4 wk.RESULTS The serum IL-6 level was associated with mortality.Within 4 wk,deceased patients had significantly higher levels of IL-6 at baseline than surviving patients[17.9(7.3-57.6)vs 10.4(4.7-22.3),P=0.011].Patients with high IL-6 levels(>11.8 pg/mL)had a higher mortality within 4 wk than those with low IL-6 levels(≤11.8 pg/mL)(24.2%vs 13.2%,P=0.004).The odds ratios calculated using univariate and multivariate logistic regression were 2.10(95%confidence interval[CI]:1.26-3.51,P=0.005)and 2.11(95%CI:1.15-3.90,P=0.017),respectively.The mortality between weeks 5 and 8 in patients with high IL-6 levels at 4 wk was 15.0%,which was significantly higher than the 6.6%mortality rate in patients with low IL-6 levels at 4 wk(hazard ratio=2.39,95%CI:1.05-5.41,P=0.037).The mortality was 5.0%in patients with high IL-6 levels at baseline and low IL-6 levels at 4 wk,7.5%in patients with low IL-6 levels both at baseline and at 4 wk,11.5%in patients with low IL-6 levels at baseline and high IL-6 levels at 4 wk,and 16.7%in patients with high IL-6 levels both at baseline and at 4 wk.The increasing trend of the mortality rate with the dynamic changes of IL-6 was significant(P for trend=0.023).CONCLUSION A high level of serum IL-6 is an independent risk factor for mortality in patients with HBV-ACLF.Furthermore,a sustained high level or dynamic elevated level of serum IL-6 indicates a higher mortality.
基金This work was financially supported by the National Nat-ural Science Foundation of China(Nos.51634001,51774023,and 51904019).
文摘On the basis of the massive amount of published literature and the long-term practice of our research group in the field of prevention and control of rockburst,the research progress and shortcomings in understanding the rockburst phenomenon have been comprehensively in-vestigated.This study focuses on the occurrence mechanism and monitoring and early warning technology for rockburst in coal mines.Results showed that the prevention and control of rockburst had made significant progress.However,with the increasing mining depth,several unre-solved concerns remain challenging.From the in-depth research and analysis,it can be inferred that rockburst disasters involve three main problems,i.e.,the induction factors are complicated,the mechanism is still unclear,and the accuracy of the monitoring equipment and multi-source stereo monitoring technology is insufficient.The monitoring and warning standards of rockburst need to be further clarified and im-proved.Combined with the Internet of Things,cloud computing,and big data,a study of the trend of rockburst needs to be conducted.Further-more,the mechanism of multiphase and multi-field coupling induced by rockburst on a large scale needs to be explored.A multisystem and multiparameter integrated monitoring and early warning system and remote monitoring cloud platform for rockburst should be explored and developed.High-reliability sensing technology and equipment and perfect monitoring and early warning standards are considered to be the de-velopment direction of rockburst in the future.This research will help experts and technicians adopt effective measures for controlling rock-burst disasters.
基金supported by the National Natural Science Foundation of China,No.81571159(to XCS)the National Natural Science Foundation for Youth of China,Nos.81601072(to CJC),81801230(to JJZ),and 81901210(to YW)。
文摘Emerging evidence indicates that pentraxin 3 is an acute-phase protein that is linked with the immune response to inflammation.It is also a newly discovered marker of anti-inflammatory A2 reactive astrocytes,and potentially has multiple protective effects in stroke;however,its role in the adult brain after traumatic brain injury is unknown.In the present study,a moderate model of traumatic brain injury in mice was established using controlled cortical impact.The models were intraventricularly injected with recombinant pentraxin 3(the recombinant pentraxin 3 group)or an equal volume of vehicle(the control group).The sham-operated mice underwent craniotomy,but did not undergo the controlled cortical impact.The potential neuroprotective and neuroregenerative roles of pentraxin 3 were investigated on days 14 and 21 after traumatic brain injury.Western blot assay showed that the expression of endogenous pentraxin 3 was increased after traumatic brain injury in mice.Furthermore,the neurological severity test and wire grip test revealed that recombinant pentraxin 3 treatment reduced the neurological severity score and increased the wire grip score,suggesting an improved recovery of sensory-motor functions.The Morris water maze results demonstrated that recombinant pentraxin 3 treatment reduced the latency to the platform,increased the time spent in the correct quadrant,and increased the number of times traveled across the platform,thus suggesting an improved recovery of cognitive function.In addition,to investigate the effects of pentraxin 3 on astrocytes,specific markers of A2 astrocytes were detected in primary astrocyte cultures in vitro using western blot assay.The results demonstrated that pentraxin 3 administration activates A2 astrocytes.To explore the protective mechanisms of pentraxin 3,immunofluorescence staining was used.Intraventricular injection of recombinant pentraxin 3 increased neuronal maintenance in the peri-injured cortex and ipsilateral hippocampus,increased the number of doublecortin-positive neural progenitor cells in the subventricular and subgranular zones,and increased the number of bromodeoxyuridine(proliferation)and neuronal nuclear antigen(mature neuron)double-labeled cells in the hippocampus and peri-injured cortex.Pentraxin 3 administration also increased the number of neurospheres and the number of bromodeoxyuridine and doublecortin double-labeled cells in neurospheres,and enhanced the proliferation of neural progenitor cells in primary neural progenitor cell cultures in vitro.In conclusion,recombinant pentraxin 3 administration activated A2 astrocytes,and consequently improved the recovery of neural function by increasing neuronal survival and enhancing neurogenesis.All experiments were approved by the Animal Ethics Committee of the First Affiliated Hospital of Chongqing Medical University,China on March 1,2016.
基金Supported by The VA Boston Healthcare System and NIH grants R01-CA75289-14,to Fujimoto JG and Mashimo HK99-EB010071-01A1,to Zhou C+2 种基金Air Force Office of Scientific Research contract FA9550-10-1-0063,to Fujimoto JGMedical Free Electron Laser Program contract FA9550-10-1-0551,to Fujimoto JGthe MIT/CIMIT Medical Engineering Fellowship,to Tsai TH
文摘AIM:To demonstrate the feasibility of optical coherence tomography(OCT)imaging in differentiating cervical inlet patch(CIP)from normal esophagus,Barrett'sesophagus(BE),normal stomach and duodenum. METHODS:This study was conducted at the Veterans Affairs Boston Healthcare System(VABHS).Patients undergoing standard esophagogastroduodenoscopy at VABHS,including one patient with CIP,one representative patient with BE and three representative normal subjects were included.White light video endoscopy was performed and endoscopic 3D-OCT images were obtained in each patient using a prototype OCT system.The OCT imaging probe passes through the working channel of the endoscope to enable simultaneous video endoscopy and 3D-OCT examination of the human gastrointestinal(GI)tract.Standard hematoxylin and eosin(H and E)histology was performed on biopsy or endoscopic mucosal resection specimens in order to compare and validate the 3D-OCT data. RESULTS:CIP was observed from a 68-year old male with gastroesophageal reflux disease.The CIP region appeared as a pink circular lesion in the upper esophagus under white light endoscopy.OCT imaging over the CIP region showed columnar epithelium structure,which clearly contrasted the squamous epithelium structure from adjacent normal esophagus.3D-OCT images obtained from other representative patients demonstrated distinctive patterns of the normal esophagus,BE,normal stomach,and normal duodenum bulb.Microstructures,such as squamous epithelium,lamina propria, muscularis mucosa,muscularis propria,esophageal glands,Barrett's glands,gastric mucosa,gastric glands, and intestinal mucosal villi were clearly observed with OCT and matched with H and E histology.These results demonstrated the feasibility of using OCT to evaluate GI tissue morphology in situ and in real-time. CONCLUSION:We demonstrate in situ evaluation of CIP microstructures using 3D-OCT,which may be a useful tool for future diagnosis and follow-up of patients with CIP.
文摘We use a two‐step hydrothermal method to successfully synthesize Sn2Nb2O7nanocrystals with an average size of approximately20nm.The as‐obtained samples are characterized by powder X‐ray diffraction,ultraviolet‐visible diffuse reflectance spectroscopy,Brunauer‐Emmett‐Teller analysis,scanning electron microscopy,and transmission electron microscopy.The photocatalytic activity of the Sn2Nb2O7nanocrystals is evaluated by photocatalytic water splitting under visible light irradiation.The Sn2Nb2O7nanocrystals with a large surface area of52.2m2/g show an enhanced visible‐light‐driven photocatalytic H2production activity,approximately5.5times higher than that of bulk Sn2Nb2O7powder.The higher photocatalytic activity of Sn2Nb2O7nanocrystals is mainly attributed to its relatively high dispersity of nanosized particles and larger specific surface area when compared with the bulk powder.
基金Projects(51575115,51775122) supported by the National Natural Science Foundation of China
文摘A theoretical model of phase change heat sink was established in terms of thermal resistance network. The influence of different parameters on the thermal resistance was analyzed and the crucial impact factors were determined. Subsequently, the forming methods including ploughing-extrusion and stamping method of boiling enhancement structure at evaporation surface were investigated, upon which three-dimensional microgroove structure was fabricated to improve the efficiency of evaporation. Moreover, the crucial parameters related to the fabrication of miniaturized phase change heat sink were optimized. The heat transfer performance of the heat sink was tested. Results show that the developed phase change heat sink has excellent heat transfer performance and is suitable for high power LED applications.