A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

新型冠状病毒(2019-nCoV)感染的肺炎诊疗快速建议指南(完整版)

2019新型冠状病毒(2019 novel coronavirus,2019-nCoV)感染的肺炎,因2019年12月发生在武汉的不明原因病毒性肺炎病例而被发现,并于2020年1月12日被世界卫生组织(World Health Organization,WHO)命名。在之后的一个月时间内,2019-nCoV在湖北省内外甚至其他国家传播造成了数以千计的病例出现,同时也引起了民众一定程度的恐慌。本指南的制订希望能够从疾病流行病学、病因学、诊断、治疗、护理、医院感染控制等方面给临床医生、社区居民等提供医疗护理及居家照护相关指导。

Time and risk factors of viral clearance in COVID-19 patients

To the Editor:Coronavirus disease 2019(COVID-19)has become a global pandemic.To minimize the risk of viral transmission in the community,some countries require two negative results of reverse transcription polymerase chain reaction(RT-PCR)for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)RNA on nasopharyngeal swabs collected≥24 h apart for hospital discharge and discontinuation of isolation.Thus,understanding the time of viral clearance is essential.However,there are limited data reporting the viral clearance time and its risk factors in COVID-19 patients.[1,2]Moreover,the numbers of patients were limited and the risk factors of viral clearance were inconsistent in these studies.Therefore,we aim to determine the time and risk factors of viral clearance in throat swabs in COVID-19 patients.

The role of isolation rooms, facemasks and intensified hand hygiene in the prevention of nosocomial COVID-19 transmission in a pulmonary clinical setting

From December 25,2019 to January 31,2020,33 cases of the coronavirus disease 2019(COVID-19)were identified in the Department of Respiratory and Critical Care Medicine of Zhongnan Hospital of Wuhan University,China,yet none of the affiliated HCWs was infected.Here we analyzed the infection control measures used in three different departments in the Zhongnan Hospital of Wuhan University and correlated the measures with the corresponding infection data of HCWs affiliated with these departments.We found that three infection control measures,namely the isolation of the presumed positive patients,the use of facemasks and intensified hand hygiene play important roles in preventing nosocomial transmission of COVID-19.