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黄土高原植被和气候对土壤侵蚀变化的影响研究
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作者 程楼 侯付闯 《水利技术监督》 2024年第4期177-181,共5页
为确定土壤侵蚀主要的控制因子,以黄土高原为例,利用相关分析和小波相干分析,分析了土壤侵蚀与控制因子之间的关系。结果表明:黄土高原土壤侵蚀整体呈下降趋势,大部分地区土壤侵蚀强度较弱,高强度土壤侵蚀区域集中在东北—西南带的丘陵... 为确定土壤侵蚀主要的控制因子,以黄土高原为例,利用相关分析和小波相干分析,分析了土壤侵蚀与控制因子之间的关系。结果表明:黄土高原土壤侵蚀整体呈下降趋势,大部分地区土壤侵蚀强度较弱,高强度土壤侵蚀区域集中在东北—西南带的丘陵沟壑区或河流密度较大的区域。地表植被覆盖变化和水土保持措施对侵蚀空间异质性的影响最为显著,降雨侵蚀力增加了土壤侵蚀。研究结果为土壤侵蚀防治提供参考。 展开更多
关键词 土壤流失 时空变异 归因分析 弹性系数法
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门脉高压脾机能亢进对根治性治疗肝癌患者预后的影响 被引量:3
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作者 娄诚 杨倩玉 +3 位作者 白同 王毅军 高英堂 杜智 《中国肿瘤临床》 CAS CSCD 北大核心 2019年第8期399-405,共7页
目的:探讨不同程度门脉高压脾机能亢进与脾切除对肝癌患者预后影响。方法:回顾性分析2008年1月至2018年1月天津市第三中心医院符合米兰标准并行根治性治疗的403例肝细胞肝癌患者临床资料。依据血小板(platelet,PLT)水平、ALBI分级、APR... 目的:探讨不同程度门脉高压脾机能亢进与脾切除对肝癌患者预后影响。方法:回顾性分析2008年1月至2018年1月天津市第三中心医院符合米兰标准并行根治性治疗的403例肝细胞肝癌患者临床资料。依据血小板(platelet,PLT)水平、ALBI分级、APRI、血小板/脾长径比值(PSR)等进行Cox比例风险回归分析,对比合并严重脾亢肝癌患者中仅行肝癌根治者与联合脾切除肝癌根治者间临床资料,采用Kaplan-Meier法进行生存分析。结果:Cox单因素、多因素分析显示,PLT水平是肝癌患者整体生存(overall survival,OS)和无瘤生存(disease free survival,DFS)的独立危险因素。不同血小板水平肝癌患者多因素OS生存曲线具有显著性差异(P=0.013)。PSR、APRI、ALBI分级等肝硬化门脉高压参数也是肝癌预后危险因素。仅行肝癌根治组与联合脾切除肝癌根治组在门脉高压脾亢程度、肝功能分级、肿瘤分期均无显著性差异(P>0.05),生存分析显示,联合脾切除组具有更长的OS(P=0.025),两组1、3、5年生存率分别为100%、98.2%、68.5%和97.1%、79.4%、56.8%。两组DFS比较无显著性差异(P=0.326)。结论:PLT、PSR、APRI、ALBI等临床参数是合并门脉高压脾亢肝癌患者重要预后影响因素。对合并严重脾亢符合米兰标准的肝癌患者,在肝癌根治同时联合脾切除可提高患者OS。 展开更多
关键词 肝细胞肝癌 门脉高压 脾机能亢进 脾切除 预后
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Negative impact of hepatitis B surface seroclearance on prognosis of hepatitis B-related primary liver cancer 被引量:4
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作者 cheng lou Tong Bai +2 位作者 Le-Wei Bi Ying-Tang Gao Zhi Du 《World Journal of Clinical Cases》 SCIE 2018年第8期192-199,共8页
AIM To assess the impact of hepatitis B surface(HBs Ag) seroclearance on survival outcomes in hepatitis B-related primary liver cancer.METHODS Information from patients with hepatitis B-related liver cancer admitted i... AIM To assess the impact of hepatitis B surface(HBs Ag) seroclearance on survival outcomes in hepatitis B-related primary liver cancer.METHODS Information from patients with hepatitis B-related liver cancer admitted in our hospital from 2008-2017 was retrieved. Cases diagnosed with HBs Ag(-) and HBc Ab(+) liver cancer were included in the HBs Ag seroclearance(SC) group. HBs Ag(+) liver cancer patients strictly matched for liver cancer stage(AJCC staging system, 8 th edition), Child-Pugh score, and first diagnosis/treatment method(surgery, ablation and TACE) were assigned to the HBsA g non-seroclearance(NSC) group. Then, clinical, pathological and survival data in both groups were assessed.RESULTS The SC and NSC groups comprised of 72 and 216 patients, respectively. Patient age(P < 0.001) and platelet count(P = 0.001) in the SC group were significantly higher than those of the NSC group. SC group patients who underwent surgery had more intrahepatic cholangiocarcinoma(ICC) and combined HCC-CC(CHC) cases than the NSC group, but no significant differences in tumor cell differentiation and history of liver cirrhosis were found between the two groups. The numbers of interventional treatments were similar in both groups(4.57 vs 5.07, P > 0.05). Overall survival was lower in the SC group than the NSC group(P = 0.019), with 1-,3-, and 5-year survival rates of 82.1% vs 85.1%, 43.2%vs 56.8%, and 27.0% vs 45.2%, respectively. Survival of patients with AJCC stage Ⅰ disease in the SC group was lower than that of the NSC group(P = 0.029).CONCLUSION Seroclearance in patients with hepatitis B-related primary liver cancer has protective effects with respect to tumorigenesis, cirrhosis, and portal hypertension but confers worse prognosis, which may be due to the frequent occurrence of highly malignant ICC and CHC. 展开更多
关键词 PRIMARY LIVER cancer HEPATITIS B SURFACE HEPATITIS B SURFACE seroclearance PROGNOSIS CHRONIC HEPATITIS B
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ALPPS in the treatment of liver cancer with insufficient future liver remnant 被引量:3
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作者 Jun-Guo Liu Jun Wang +5 位作者 Wei Sun Jin-Juan Zhang Yi-Jun Wang Gui-Ming Shu cheng lou Zhi Du 《Hepatobiliary & Pancreatic Diseases International》 SCIE CAS CSCD 2021年第4期400-402,共3页
To the Editor:In 2007,Schlitt firstly reported that the rapid compensatory increase of future liver remnant (FLR) after surgery can be achieved in a very short time which is known as a revolutionary breakthrough of li... To the Editor:In 2007,Schlitt firstly reported that the rapid compensatory increase of future liver remnant (FLR) after surgery can be achieved in a very short time which is known as a revolutionary breakthrough of liver surgery for huge or multiple liver cancer therapy^([1]).de Santibanes and Clavien later proposed the medical term"ALPPS"^([2]). 展开更多
关键词 ALPPS SURGERY LIVER
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机器视觉波纹阻火盘表面波高测量方法 被引量:2
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作者 刘磊 陈爱军 +1 位作者 程楼 丁佳为 《中国测试》 CAS 北大核心 2020年第6期44-50,共7页
针对目前波纹阻火盘采用人工取点的方式对波高进行测量引起的效率低、误差大等问题,提出一种基于机器视觉的波纹阻火盘表面波高测量方法。该方法先利用线阵CCD相机配合二维运动平台扫描的方式获取图像,再利用改进的FLANN自适应特征点匹... 针对目前波纹阻火盘采用人工取点的方式对波高进行测量引起的效率低、误差大等问题,提出一种基于机器视觉的波纹阻火盘表面波高测量方法。该方法先利用线阵CCD相机配合二维运动平台扫描的方式获取图像,再利用改进的FLANN自适应特征点匹配筛选算法优化拼接过程,提高线阵图像配准准确度,然后采用基于Zernike矩的亚像素边缘检测算法准确获取边缘定位,并结合该文提出的波高尺寸测量原理以及最小二乘法,确定最大波高对应的两个像素点的坐标,最后根据线阵相机标定结果计算得到实际波高尺寸。利用波纹阻火盘线阵图像进行实验,并与影像仪法测量结果进行对比,实验结果表明该测量方法测量误差在±0.02 mm以内,满足实际工业生产需要。 展开更多
关键词 图像处理 波纹阻火盘 尺寸测量 图像拼接 亚像素边缘检测
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Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication 被引量:4
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作者 Ye Zhang Zhi Du +6 位作者 Tong Bai Ying-Tang Gao Yi-Jun Wang cheng lou Feng-Mei Wang Yu Bai Bin Yang 《World Journal of Gastroenterology》 SCIE CAS CSCD 2012年第17期2043-2052,共10页
AIM:To investigate the methylation status of secreted protein acidic and rich in cysteine(SPARC) in human hepatocellular carcinoma(HCC) and evaluate its clinical implication.METHODS:The methylation status of SPARC was... AIM:To investigate the methylation status of secreted protein acidic and rich in cysteine(SPARC) in human hepatocellular carcinoma(HCC) and evaluate its clinical implication.METHODS:The methylation status of SPARC was analyzed in one HCC cell line(SMMC-7721) and 60 pairs of HCC and corresponding nontumorous tissues by methylation-specific polymerase chain reaction and bisulfite sequencing.The expression of SPARC mRNA and protein were examined by reverse transcription polymerase chain reaction and immunohistochemistry,respectively.The correlations between the methylation status and the gene expression,the clinicopathological parameters,as well as the prognosis after surgery were analyzed.RESULTS:In the SMMC-7721 cell line,the loss of SPARC expression was correlated with the aberrant methylation and could be reactivated by the demethylating agent 5-aza-2'-deoxycytidine.Methylation frequency of SPARC in HCC was significantly higher than that in the corresponding nontumorous tissues(45/60 vs 7/60,P < 0.001),and it was correlated with the pathological classification(P = 0.019).The downregulation of the SPARC mRNA expression in HCC was correlated with the SPARC methylation(P = 0.040).The patients with methylated SPARC had a poorer overall survival than those without methylated SPARC(28.0 mo vs 41.0 mo,P = 0.043).CONCLUSION:Aberrant methylation is an important mechanism for SPARC inactivation in HCC and SPARC methylation may be a promising biomarker for the diagnosis and prognosis of HCC. 展开更多
关键词 Biomarker Diagnosis Hepatocellular carcinoma Methylation Prognosis Tumor suppressor gene
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气体静压小孔节流焦耳-汤姆逊效应的测试研究 被引量:1
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作者 程楼 禹静 +3 位作者 李东升 罗钦 尹健龙 沈小燕 《中国测试》 CAS 北大核心 2022年第5期1-5,共5页
节流器在工作中由于高压气体与壁面的摩擦,导致气体的压强与温度同时发生变化,进而影响节流器性能,因此研究节流过程中压强与温度的变化有助于分析节流器特性。通过建立基于焦耳-汤姆逊效应的节流器小孔节流温降与压降理论模型,进行理... 节流器在工作中由于高压气体与壁面的摩擦,导致气体的压强与温度同时发生变化,进而影响节流器性能,因此研究节流过程中压强与温度的变化有助于分析节流器特性。通过建立基于焦耳-汤姆逊效应的节流器小孔节流温降与压降理论模型,进行理论计算,并搭建实验装置完成相关的实验验证。实验结果表明:1)理论值与实验值在气膜厚度、进气口压强的相关性上具有一致性;2)理论值与实验值在三种节流器基本曲线的特征上具有一致性。证明该理论模型在气体静压小孔节流焦耳-汤姆逊效应研究存在有效性,为节流器节流孔的设计以及供气压强与气膜厚度的选择提供理论基础。 展开更多
关键词 焦耳-汤姆逊效应 小孔节流 有限差分 气体静压
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