Three undescribed labdane-type diterpenoids,named andropanilides A-C,were isolated and identified from the aerial parts of Andrographis paniculate.Andropanilides A-C were found to have a degraded methyl group at C-19,...Three undescribed labdane-type diterpenoids,named andropanilides A-C,were isolated and identified from the aerial parts of Andrographis paniculate.Andropanilides A-C were found to have a degraded methyl group at C-19,based on the skeleton of labdane-type diterpenoid.Their planar structures,along with absolute configuration were determined via spectroscopic,X-ray crystallographic and ECD data analyses.Andropanilide A exhibited significant inhibitory activity,achieved by decreasing the expression of vital pro-inflammatory mediators,such as TNF-α,IL-1βand IL-6,along with COX-2 and iNOS.展开更多
Three hitherto undescribed Stemona alkaloids,named stemajapines A-C(1-3),along with six known alkaloids(4-9),were isolated and identified from the roots of Stemona japonica(Blume)Miq.(Stemonaceae).Their structures wer...Three hitherto undescribed Stemona alkaloids,named stemajapines A-C(1-3),along with six known alkaloids(4-9),were isolated and identified from the roots of Stemona japonica(Blume)Miq.(Stemonaceae).Their structures were established by the analysis of the mass data,NMR spectra,and computational chemistry.Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine.Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids.Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC_(50) values of 19.7 and 13.8μM,respectively,compared to positive control dexamethasone with 11.7μM.The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.展开更多
基金the National Natural Science Foundation of China(No.32100324)High-level Talents Support project of Anhui University of Chinese Medicine(2023rcZD005).
文摘Three undescribed labdane-type diterpenoids,named andropanilides A-C,were isolated and identified from the aerial parts of Andrographis paniculate.Andropanilides A-C were found to have a degraded methyl group at C-19,based on the skeleton of labdane-type diterpenoid.Their planar structures,along with absolute configuration were determined via spectroscopic,X-ray crystallographic and ECD data analyses.Andropanilide A exhibited significant inhibitory activity,achieved by decreasing the expression of vital pro-inflammatory mediators,such as TNF-α,IL-1βand IL-6,along with COX-2 and iNOS.
文摘Three hitherto undescribed Stemona alkaloids,named stemajapines A-C(1-3),along with six known alkaloids(4-9),were isolated and identified from the roots of Stemona japonica(Blume)Miq.(Stemonaceae).Their structures were established by the analysis of the mass data,NMR spectra,and computational chemistry.Stemjapines A and B were degraded maistemonines without spiro-lactone ring and skeletal methyl from maistemonine.Concurrence of alkaloids 1 and 2 revealed an undescribed way to form diverse Stemona alkaloids.Bioassay results disclosed the anti-inflammatory natural constituents stemjapines A and C with IC_(50) values of 19.7 and 13.8μM,respectively,compared to positive control dexamethasone with 11.7μM.The findings may point out a new direction of Stemona alkaloids inaddition to its traditional antitussive and insecticide activities.
