To enhance the diversity and distribution uniformity of initial population,as well as to avoid local extrema in the Chimp Optimization Algorithm(CHOA),this paper improves the CHOA based on chaos initialization and Cau...To enhance the diversity and distribution uniformity of initial population,as well as to avoid local extrema in the Chimp Optimization Algorithm(CHOA),this paper improves the CHOA based on chaos initialization and Cauchy mutation.First,Sin chaos is introduced to improve the random population initialization scheme of the CHOA,which not only guarantees the diversity of the population,but also enhances the distribution uniformity of the initial population.Next,Cauchy mutation is added to optimize the global search ability of the CHOA in the process of position(threshold)updating to avoid the CHOA falling into local optima.Finally,an improved CHOA was formed through the combination of chaos initialization and Cauchy mutation(CICMCHOA),then taking fuzzy Kapur as the objective function,this paper applied CICMCHOA to natural and medical image segmentation,and compared it with four algorithms,including the improved Satin Bowerbird optimizer(ISBO),Cuckoo Search(ICS),etc.The experimental results deriving from visual and specific indicators demonstrate that CICMCHOA delivers superior segmentation effects in image segmentation.展开更多
Atrial fibrillation(AF)is the most prevalent cardiac arrhythmia seen in clinical settings,which has been associated with substantial rates of mortality and morbidity.However,clinically available drugs have limited eff...Atrial fibrillation(AF)is the most prevalent cardiac arrhythmia seen in clinical settings,which has been associated with substantial rates of mortality and morbidity.However,clinically available drugs have limited efficacy and adverse effects.We aimed to investigate the mechanisms of action of andrographolide(Andr)with respect to AF.We used network pharmacology approaches to investigate the possible therapeutic effect of Andr.To define the role of Andr in AF,HL-1 cells were pro-treated with Andr for 1 h before rapid electronic stimulation(RES)and rabbits were pro-treated for 1 d before rapid atrial pacing(RAP).Apoptosis,myofibril degradation,oxidative stress,and inflammation were determined.RNA sequencing(RNA-seq)was performed to investigate the relevant mechanism.Andr treatment attenuated RAP-induced atrial electrophysiological changes,inflammation,oxidative damage,and apoptosis both in vivo and in vitro.RNA-seq indicated that oxidative phosphorylation played an important role.Transmission electron microscopy and adenosine triphosphate(ATP)content assay respectively validated the morphological and functional changes in mitochondria.The translocation of nuclear factor erythroid 2-related factor 2(Nrf2)to the nucleus and the molecular docking suggested that Andr might exert a therapeutic effect by influencing the Keap1-Nrf2 complex.In conclusions,this study revealed that Andr is a potential preventive therapeutic drug toward AF via activating the translocation of Nrf2 to the nucleus and the upregulation of heme oxygenase-1(HO-1)to promote mitochondrial bioenergetics.展开更多
基金This work is supported by Natural Science Foundation of Anhui under Grant 1908085MF207,KJ2020A1215,KJ2021A1251 and 2023AH052856the Excellent Youth Talent Support Foundation of Anhui underGrant gxyqZD2021142the Quality Engineering Project of Anhui under Grant 2021jyxm1117,2021kcszsfkc307,2022xsxx158 and 2022jcbs043.
文摘To enhance the diversity and distribution uniformity of initial population,as well as to avoid local extrema in the Chimp Optimization Algorithm(CHOA),this paper improves the CHOA based on chaos initialization and Cauchy mutation.First,Sin chaos is introduced to improve the random population initialization scheme of the CHOA,which not only guarantees the diversity of the population,but also enhances the distribution uniformity of the initial population.Next,Cauchy mutation is added to optimize the global search ability of the CHOA in the process of position(threshold)updating to avoid the CHOA falling into local optima.Finally,an improved CHOA was formed through the combination of chaos initialization and Cauchy mutation(CICMCHOA),then taking fuzzy Kapur as the objective function,this paper applied CICMCHOA to natural and medical image segmentation,and compared it with four algorithms,including the improved Satin Bowerbird optimizer(ISBO),Cuckoo Search(ICS),etc.The experimental results deriving from visual and specific indicators demonstrate that CICMCHOA delivers superior segmentation effects in image segmentation.
基金supported by the National Natural Science Foundation of China(No.82270317)the Zhejiang Provincial Natural Science Foundation of China(No.LY19H020011).
文摘Atrial fibrillation(AF)is the most prevalent cardiac arrhythmia seen in clinical settings,which has been associated with substantial rates of mortality and morbidity.However,clinically available drugs have limited efficacy and adverse effects.We aimed to investigate the mechanisms of action of andrographolide(Andr)with respect to AF.We used network pharmacology approaches to investigate the possible therapeutic effect of Andr.To define the role of Andr in AF,HL-1 cells were pro-treated with Andr for 1 h before rapid electronic stimulation(RES)and rabbits were pro-treated for 1 d before rapid atrial pacing(RAP).Apoptosis,myofibril degradation,oxidative stress,and inflammation were determined.RNA sequencing(RNA-seq)was performed to investigate the relevant mechanism.Andr treatment attenuated RAP-induced atrial electrophysiological changes,inflammation,oxidative damage,and apoptosis both in vivo and in vitro.RNA-seq indicated that oxidative phosphorylation played an important role.Transmission electron microscopy and adenosine triphosphate(ATP)content assay respectively validated the morphological and functional changes in mitochondria.The translocation of nuclear factor erythroid 2-related factor 2(Nrf2)to the nucleus and the molecular docking suggested that Andr might exert a therapeutic effect by influencing the Keap1-Nrf2 complex.In conclusions,this study revealed that Andr is a potential preventive therapeutic drug toward AF via activating the translocation of Nrf2 to the nucleus and the upregulation of heme oxygenase-1(HO-1)to promote mitochondrial bioenergetics.
